Catalog No.
YMK98301
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Glu641-Thr756
Predicted molecular weight
15.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9JHE3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Acylsphingosine deacylase 2, Neutral ceramidase, NCDase, N-acylsphingosine amidohydrolase 2, Asah2, N-CDase
Lipid metabolism associated PLPP4 gene drives oncogenic and adipogenic potential in breast cancer cells., PMID:40187483
High Dose C6 Ceramide-Induced Response in Embryonic Hippocampal Cells., PMID:40149966
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
Identification of Downregulated MECR Gene in Parkinson's Disease Through Integrated Transcriptomic Analysis and Validation., PMID:39859268
Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer., PMID:38669694
Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating α1,2-Fucosylation of Asah2 and Npc1., PMID:38550777
Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages., PMID:38302493
The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer's disease model mice and its mechanism., PMID:38277004
Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population., PMID:37944753
RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression., PMID:37107551
Acute physiological effects following Bacillus subtilis DE111 oral ingestion - a randomised, double blinded, placebo-controlled study., PMID:36790091
Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models., PMID:36630483
Low-grade elevation of palmitate and lipopolysaccharide synergistically induced β-cell damage via inhibition of neutral ceramidase., PMID:34610358
Skin Mast Cell-Driven Ceramides Drive Early Apoptosis in Pre-Symptomatic Eczema in Mice., PMID:34360617
New candidate blood biomarkers potentially associated with white matter hyperintensities progression., PMID:34253757
Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis., PMID:33547170
Colon Cancer and Perturbations of the Sphingolipid Metabolism., PMID:31801289
In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism., PMID:31766565
Changes in the Metabolism of Sphingoid Bases in the Brain and Spinal Cord of Transgenic FUS(1-359) Mice, a Model of Amyotrophic Lateral Sclerosis., PMID:31694512
Comparative Whole-Transcriptome Profiling of Liver Tissue from Wistar Rats Fed with Diets Containing Different Amounts of Fat, Fructose, and Cholesterol., PMID:31693469
Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow-Induced Dilation in the Human Microvasculature., PMID:31462128
Targeted proteomic response to coffee consumption., PMID:31154491
Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma., PMID:31022733
Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer., PMID:30389354
[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]., PMID:28879748
Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death., PMID:26747710
Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase., PMID:26190575
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase., PMID:24064302
Transcriptional regulation of the human neutral ceramidase gene., PMID:21531200
AP-1 binding transcriptionally regulates human neutral ceramidase., PMID:21530485
Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter., PMID:20803549
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate., PMID:18619555
Purification and characterization of human intestinal neutral ceramidase., PMID:17475390
A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease., PMID:17334805
Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites., PMID:17211142
Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase., PMID:17204455
Ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa., PMID:17202150
Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space., PMID:16963225
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids., PMID:16380386
Absorption and lipoprotein transport of sphingomyelin., PMID:16251722
Identification of a novel amidase motif in neutral ceramidase., PMID:16229686
Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets., PMID:16061940
Subcellular localization of human neutral ceramidase expressed in HEK293 cells., PMID:15845354
Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels., PMID:15710421
Rat intestinal ceramidase: purification, properties, and physiological relevance., PMID:15217782
Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids., PMID:15184394
Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice., PMID:15137923
Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase., PMID:15123644
Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus., PMID:14742298
Neutral ceramidase gene: role in regulating ceramide-induced apoptosis., PMID:14557071
For research use only. Not for human or drug use.
