Catalog No.
YMH18901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr26-Pro254
Predicted molecular weight
28.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8K4F0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD226 antigen, Platelet and T-cell activation antigen 1, Pta1, CD226, Cd226
Proteome-wide Mendelian randomization reveals causal associations between plasma proteins and autoimmune thyroid disease., PMID:40481092
Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407
Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib., PMID:40388487
Altered CD27-related T cell subsets reflect immune imbalance in systemic lupus erythematosus., PMID:40381105
TIGIT blockade increases efficacy of PD-1 blockade combined with radiation therapy in triple-negative breast cancer model., PMID:40360046
Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320
T-cell immunoglobulin and ITIM domain as a target in combo anti-PD-(L)1 cancer therapy., PMID:40294684
Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments., PMID:40113758
PVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR., PMID:40073261
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters., PMID:40027624
Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor microenvironment., PMID:40010766
Immune Checkpoint Receptor Expression Profiles of MAIT Cells in Moderate and Severe COVID-19., PMID:39980239
Treg fitness signatures as a biomarker for disease activity in Juvenile Idiopathic Arthritis., PMID:39954509
Inhibition of TIGIT on NK cells improves their cytotoxicity and HIV reservoir eradication potential., PMID:39918313
CD73 promotes the maturation of murine NK cells and their survival in the tumor microenvironment., PMID:39901844
Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy., PMID:39871281
Enhanced co-expression of TIGIT and PD-1 on γδ T cells correlates with clinical features and laboratory parameters in patients with primary Sjögren's syndrome., PMID:39856468
Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia., PMID:39777847
Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells., PMID:39754720
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC., PMID:39725799
TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation., PMID:39681653
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function., PMID:39636437
Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity., PMID:39506082
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases., PMID:39465485
TGF-β-mediated crosstalk between TIGIT+ Tregs and CD226+CD8+ T cells in the progression and remission of type 1 diabetes., PMID:39406740
Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2., PMID:39349829
CD226 implicated in Akt-dependent apoptosis of CD4+ T cell contributes to asthmatic pathogenesis., PMID:39349422
The role of imbalanced CD226/TIGIT on activated peripheral double-negative T cells in the pathogenesis of primary Sjögren's syndrome., PMID:39263792
SPP1+ TAM Regulates the Metastatic Colonization of CXCR4+ Metastasis-Associated Tumor Cells by Remodeling the Lymph Node Microenvironment., PMID:39236316
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions., PMID:39231385
Clinical response and pathway-specific correlates following TIGIT-LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial., PMID:39187595
Immunological Profiling of CD8+ and CD8- NK Cell Subpopulations and Immune Checkpoint Alterations in Early-Onset Preeclampsia and Healthy Pregnancy., PMID:39125946
Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells., PMID:39113892
Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function., PMID:39071293
Therapeutic targets for age-related macular degeneration: proteome-wide Mendelian randomization and colocalization analyses., PMID:38903171
NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in multiple myeloma., PMID:38875515
Expression of CD226 on γδ T cells is lower in advanced chronic lymphocytic leukemia and correlates with IgA, IgG and LDH levels., PMID:38819939
A novel enzyme-linked immunosorbent assay tool to evaluate plasma soluble CD226 in primary Sjögren's syndrome., PMID:38768695
CD226 promotes renal fibrosis by regulating macrophage activation and migration., PMID:38660893
Mendelian randomization and colocalization analysis reveal novel drug targets for myasthenia gravis., PMID:38659056
Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells., PMID:38635895
Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases., PMID:38612837
TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes., PMID:38533515
Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis., PMID:38521921
CD155 as an emerging target in tumor immunotherapy., PMID:38518596
Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk., PMID:38478144
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway., PMID:38386917
Anti-PD-1 therapy reverses TIGIT+CD226+NK depletion in immunotherapy resistance of hepatocellular carcinoma through PVR/TIGIT pathway., PMID:38368771
Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients., PMID:38326745
For research use only. Not for human or drug use.
