Catalog No.
YMK27801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Glu50-Ser173
Predicted molecular weight
16.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7TS55
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gitrl, GITRL, GITR ligand, Tnfsf18, Glucocorticoid-induced TNF-related ligand, Tumor necrosis factor ligand superfamily member 18
GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy., PMID:39863927
Maternal Exposure to Polystyrene Nanoplastics Disrupts Spermatogenesis in Mouse Offspring by Inducing Prdm14 Overexpression in Undifferentiated Spermatogonia., PMID:39791560
A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome., PMID:38589318
GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice., PMID:38321001
Comparative evaluation of antitumor effects of TNF superfamily costimulatory ligands delivered by mesenchymal stem cells., PMID:37995568
Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection., PMID:37992765
γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection., PMID:37644007
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy., PMID:37337107
Defining a Correlative Transcriptional Signature Associated with Bulk Histone H3 Acetylation Levels in Adult Glioblastomas., PMID:36766715
Expression profile of immunoregulatory factors in canine tumors., PMID:36327941
GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome., PMID:36301339
Identification of senescence-related molecular subtypes and key genes for prostate cancer., PMID:36124532
First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome., PMID:35680011
MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer., PMID:35664337
Cellular landscape of tumour microenvironment in prostate cancer., PMID:35146758
GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis., PMID:34589088
Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation., PMID:34551288
Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium., PMID:34502527
Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma., PMID:34312483
Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling., PMID:34293591
Immune-related genes and gene sets for predicting the response to anti-programmed death 1 therapy in patients with primary or metastatic non-small cell lung cancer., PMID:34084219
Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions., PMID:33654081
GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation., PMID:33557842
Platelet-expressed immune checkpoint regulator GITRL in breast cancer., PMID:33538861
Characterization of the Cell Surface Phenotype and Regulatory Activity of B-Cell IgD Low (BDL) Regulatory B Cells., PMID:33479901
Type I interferons drive the maturation of human DC3s with a distinct costimulatory profile characterized by high GITRL., PMID:33188059
Induction of Antigen-Independent Proliferation of Regulatory T-Cells by TNF Superfamily Ligands OX40L and GITRL., PMID:33185867
The Role of GITR/GITRL Interaction in Autoimmune Diseases., PMID:33163004
Low-Dose LPS Induces Tolerogenic Treg Skewing in Asthma., PMID:33072079
The involvement of protein TNFSF18 in promoting p-STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model., PMID:32820830
Effects of protein-protein interface disruptors at the ligand of the glucocorticoid-induced tumor necrosis factor receptor-related gene (GITR)., PMID:32569630
Immune Landscape of the B7 and TNFR Families in Oral Squamous Cell Carcinoma., PMID:32548602
Biological role of GITR/GITRL in attributes and immune responses of macrophage., PMID:31833599
Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages., PMID:31725732
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality., PMID:31324216
Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis., PMID:31118027
Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome., PMID:30760623
Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells., PMID:30683721
FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes., PMID:30679758
Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis., PMID:30643147
Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line., PMID:30621583
GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation., PMID:30487647
Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages., PMID:29521598
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity., PMID:29150240
Dense Genotyping of Immune-Related Regions Identifies Loci for Rheumatoid Arthritis Risk and Damage in African Americans., PMID:28681901
The Proinflammatory Cytokine GITRL Contributes to TRAIL-mediated Neurotoxicity in the HCN-2 Human Neuronal Cell Line., PMID:28524007
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases., PMID:28275260
A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist., PMID:28069723
Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report., PMID:27444204
Serum Levels of TNF Receptor Ligands Are Dysregulated in Sepsis and Predict Mortality in Critically Ill Patients., PMID:27124414
For research use only. Not for human or drug use.
