Catalog No.
YMK97201
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr186-Lys277
Predicted molecular weight
12.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P97401
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Frzb, Frezzled, sFRP-3, Fre, Frzb1, Secreted frizzled-related protein 3, Frizzled-related protein 1, Sfrp3, Fiz, Fritz, FrzB-1
MicroRNA-27a transfected dental pulp stem cells undergo odonto/osteogenic differentiation via targeting DKK3 and SOSTDC1 in Wnt/BMP signaling in vitro and enhance bone formation in vivo., PMID:39956898
Modulating vascular smooth muscle cell phenotype via Wnt-Independent FRZB pathways., PMID:39778670
Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation., PMID:39644393
High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects., PMID:39582775
Exploring the predictive values of SERP4 and FRZB in dilated cardiomyopathy based on an integrated analysis., PMID:39425025
Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis., PMID:39344191
Dynamic Transcriptome Analysis of SFRP Family in Guided Bone Regeneration With Occlusive Periosteum in Swine Model., PMID:39042069
Sizzled (Frzb3) physically interacts with noncanonical Wnt ligands to inhibit gastrulation cell movement., PMID:38759887
SFRP1 decreases WNT-Mediated M2 macrophage marker expression in breast tissue., PMID:38554160
WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis., PMID:38172596
Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis., PMID:37996473
Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1., PMID:37569774
Exosomal microRNA‑4516, microRNA‑203 and SFRP1 are potential biomarkers of acute myocardial infarction., PMID:37203392
Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice., PMID:36309688
Membrane Frizzled-Related Protein-Related Disease Mimicking Idiopathic Intracranial Hypertension., PMID:36255095
Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice., PMID:36174667
Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging., PMID:36084952
Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity., PMID:36077270
SFRP1 Negatively Modulates Pyroptosis of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis: A Review., PMID:35795672
FRZB is Regulated by the Transcription Factor EGR1 and Inhibits the Growth and Invasion of Triple-Negative Breast Cancer Cells by Regulating the JAK/STAT3 Pathway., PMID:35787980
BMP-AKT-GSK3β Signaling Restores Hair Follicle Stem Cells Decrease Associated with Loss of Sfrp1., PMID:35689817
UVB-induced SFRP1 methylation potentiates skin damage by promoting cell apoptosis and DNA damage., PMID:35657114
Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling., PMID:35589066
Secreted frizzled-related protein 5 promotes angiogenesis of human umbilical vein endothelial cells and alleviates myocardial injury in diabetic mice with myocardial infarction by inhibiting Wnt5a/JNK signaling., PMID:35506262
Highly Purified Eicosapentaenoic Acid Alleviates the Inflammatory Response and Oxidative Stress in Macrophages during Atherosclerosis via the miR-1a-3p/sFRP1/Wnt/PCP-JNK Pathway., PMID:35464772
Circulating level of serum secreted frizzled-related protein 5 decreases in polycystic ovary syndrome., PMID:35400241
Epigenetic network of EZH2/SFRP1/Wnt in the epithelial-mesenchymal transition of laryngeal carcinoma cells., PMID:35400167
Secreted frizzled-related protein 4 exerts anti-atherosclerotic effects by reducing inflammation and oxidative stress., PMID:35364070
Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition., PMID:35348006
Downregulation of secreted frizzled-related protein 4 inhibits hypoxia/reoxygenation injury in diabetic cardiomyocytes by protein tyrosine phosphatase nonreceptor type 12., PMID:35290144
Drivers of Type 2 Inflammation in Allergic Airway Disease: Wnt You Like to Know?, PMID:35030311
The Role of Secreted Frizzled-related Protein-1 in Allergic Asthma., PMID:34929134
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis., PMID:34730803
Secreted Frizzled-Related Protein 1 Promotes Odontoblastic Differentiation and Reparative Dentin Formation in Dental Pulp Cells., PMID:34572140
SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation., PMID:34569685
Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness., PMID:34383712
Circular RNA circ_0046264 Suppresses Osteosarcoma Progression via microRNA-940/Secreted Frizzled Related Protein 1 Axis., PMID:34305100
[CRL4B complex promotes the development of pancreatic cancer by inhibiting secreted frizzled related protein 1]., PMID:34289556
Serum secreted frizzled-related protein 5 in relation to insulin sensitivity and its regulation by insulin and free fatty acids., PMID:34184187
Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia., PMID:33965401
Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos., PMID:33904408
LncRNA UCA1 alleviates aberrant hippocampal neurogenesis through regulating miR-375/SFRP1-mediated WNT/β-catenin pathway in kainic acid-induced epilepsy., PMID:33829718
Glucocorticoid therapy suppresses Wnt signaling by reducing the ratio of serum Wnt3a to Wnt inhibitors, sFRP-1 and Wif-1., PMID:33420868
Wnt antagonist secreted frizzled-related protein I (sFRP1) may be involved in the osteogenic differentiation of periodontal ligament cells in chronic apical periodontitis., PMID:33290588
FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity., PMID:33245093
Computational design of antagonist peptides based on the structure of secreted frizzled-related protein-1 (SFRP1) aiming to inhibit Wnt signaling pathway., PMID:33155881
Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174
Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis., PMID:33140138
Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis., PMID:33028902
Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway., PMID:32978504
For research use only. Not for human or drug use.
