Catalog No.
YMK97001
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Phe305-Met347
Predicted molecular weight
32.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9CPV9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
P2ry12, P2Y purinoceptor 12, P2Y12
Hippocampal microglial activation induces cognitive impairment and allodynia through neuronal plasticity changes in male mice with neuropathic pain., PMID:40254263
Alterations in Gene Expression and Alternative Splicing Induced by Plasmid-Mediated Overexpression of GFP and P2RY12 Within the A549 Cell Line., PMID:40243586
Preventing the antigen-presenting function of retinal microglia blocks autoimmune neuroinflammation by dendritic cell-primed CD4+ T cells., PMID:40239533
Prasugrel Intermediate Metabolite Modulates Platelet Inhibition by Negatively Interfering With an Active Metabolite: An Ex Vivo, In Vitro, and In Silico Study., PMID:40109258
Purinergic System Transcript Changes in the Dorsolateral Prefrontal Cortex in Suicide and Major Depressive Disorder., PMID:40076453
P2Y12 signaling in muscle satellite cells contributes to masseter muscle contraction-induced pain., PMID:40057215
Effects of Pesticide Exposure on Neuroinflammation and Microglial Gene Expression: Relevance to Mechanisms of Alzheimer's Disease Risk., PMID:40027678
P2Y12-mediated HIV gp120 and ddC-induced neuropathic pain improved by esculin., PMID:39976049
Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction., PMID:39936089
Association of P2RY12 Gene Variants and Non-Genetic Factors With Clopidogrel Responsiveness in Vietnamese Patients After Percutaneous Coronary Intervention: A Cross-Sectional Study., PMID:39927599
Sex-specific activation of platelet purinergic signaling is key in local cytokine release and phagocytosis in the peritoneal cavity in intra-abdominal sepsis., PMID:39854048
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39., PMID:39843911
Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions., PMID:39828750
P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways., PMID:39755188
A topographic approach to the markers of macrophage/microglia and other cell types in high grade glioma., PMID:39734023
Differentiating multiple sclerosis with predominant spinal cord and optic nerve involvement from other autoimmune demyelinating diseases using B cell immunophenotyping and gene expression profiling., PMID:39729902
The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology., PMID:39581554
Nanodomains enriched in arachidonic acid promote P2Y12 receptor oligomerization in the platelet plasma membrane., PMID:39557210
Effect of Calcium Channel Blockers on Antiplatelet Activity of Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention: Insights from the PTRG-DES Consortium., PMID:39552592
In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons., PMID:39397028
P2Y12-targeted modulation of microglial phenotypes: A novel therapeutic strategy for enhanced axonal regeneration post-spinal cord injury., PMID:39277132
Engineered P2Y12-Overexpressing Cell-Membrane-Wrapped Nanoparticles for the Functional Reversal of Ticagrelor and Clopidogrel., PMID:39140872
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta., PMID:39129007
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense., PMID:39074615
Physical Exercise Improves the Neuronal Function in Ischemic Stroke Via Microglial CB2R/P2Y12 Signaling., PMID:39066973
Analysis of LRRN3, MEF2C, SLC22A, and P2RY12 Gene Expression in the Peripheral Blood of Patients in the Early Stages of Parkinson's Disease., PMID:39061965
Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis., PMID:39032599
Ticagrelor 60 vs. 90 mg in elderly ACS patients undergoing PCI: a randomized, crossover trial., PMID:39025785
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets., PMID:39014887
The influence of P2Y12 gene polymorphisms on clopidogrel therapy in patients after percutaneous coronary intervention., PMID:38953340
Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices., PMID:38926390
Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex., PMID:38844243
Retinal microglia express more MHC class I and promote greater T-cell-driven inflammation than brain microglia., PMID:38799448
Cerebrospinal fluid immune cells appear similar across neuropathic and non-neuropathic pain conditions., PMID:38707493
A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies., PMID:38622726
P2Y12 Inhibition in Patients Requiring Oral Anticoagulation After Percutaneous Coronary Intervention: The SWAP-AC-2 Study., PMID:38597172
Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia., PMID:38593701
Retinal microglia exacerbate uveitis by functioning as local antigen-presenting cells., PMID:38585800
Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h., PMID:38582805
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders., PMID:38576039
Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12., PMID:38561055
Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy., PMID:38518636
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12., PMID:38468308
High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease., PMID:38456510
Antithrombotic Stewardship: Evaluation of Platelet Reactivity-Guided Cangrelor Dosing Using the VerifyNow Assay., PMID:38335531
Sex-specific effects of ketogenic diet on anxiety-like behavior and neuroimmune response in C57Bl/6J mice., PMID:38311044
Early involvement of peripherally derived monocytes in inflammation in an NMO-like mouse model., PMID:38216632
Guided Anti-P2Y12 Therapy in Patients Undergoing Percutaneous Coronary Intervention., PMID:37992750
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells., PMID:37865779
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency., PMID:37775760
For research use only. Not for human or drug use.
