Catalog No.
YHK96801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn207-Asp265
Predicted molecular weight
34.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96BI3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor, APH-1a, APH1A, Aph-1alpha
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
The effect of overexpression of CyPA on gene expression in human umbilical vein endothelial cells., PMID:39029007
Mendelian randomization analysis identifies druggable genes and drugs repurposing for chronic obstructive pulmonary disease., PMID:38660492
Unraveling the link between PTBP1 and severe asthma through machine learning and association rule mining method., PMID:37717070
Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors., PMID:37657269
Selective inhibitors of the PSEN1-gamma-secretase complex., PMID:37164155
Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons., PMID:37031474
HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma., PMID:36973704
De novo assembly of a chromosome-level reference genome of the ornamental butterfly Sericinus montelus based on nanopore sequencing and Hi-C analysis., PMID:36968580
In Vitro and In Vivo Neuroprotective Effects of Sarcosine., PMID:36281465
GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation., PMID:35858570
A Data Science Approach for the Identification of Molecular Signatures of Aggressive Cancers., PMID:35565454
Specific Mutations in Aph1 Cause γ-Secretase Activation., PMID:35008932
Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease., PMID:34879266
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum., PMID:34292306
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes., PMID:33808143
Investigation of gamma secretase gene complex mutations in German population with Hidradenitis suppurativa designate a complex polygenic heritage., PMID:33559291
Hidradenitis Suppurativa: Proposal of Classification in Two Endotypes with Two-Step Cluster Analysis., PMID:33171462
Membrane dynamics of γ-secretase with the anterior pharynx-defective 1B subunit., PMID:32830360
SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions., PMID:32184288
Negative evidence for a role of APH1B T27I variant in Alzheimer's disease., PMID:31995180
ECOD: identification of distant homology among multidomain and transmembrane domain proteins., PMID:31226926
APH-1A Component of γ-Secretase Forms an Internal Water and Ion-Containing Cavity., PMID:30979338
Evaluation of the prognostic significances of γ-secretase genes in pancreatic cancer., PMID:30944650
Jagged1 promotes mineralization in human bone-derived cells., PMID:30682716
miR-151-5p modulates APH1a expression to participate in contextual fear memory formation., PMID:30663934
Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1α/β and Presenilin 1 expression via PGE2 and PGD2 at the early stage of Alzheimer's Disease., PMID:30383537
Absence of morningness alleles in non-European populations., PMID:30084654
Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization., PMID:29078389
Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions., PMID:28753424
Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer's disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a., PMID:28588301
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration., PMID:28588032
[Effect of βsheet blocking peptide H102 on APP metabolic enzymes in hippocampal brain of double transgenic AD mice]., PMID:29926633
Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein., PMID:28302486
Huannao Yicong Formula () regulates γ-secretase activity through APH-1 and PEN-2 gene ragulation pathways in hippocampus of APP/PS1 double transgenic mice., PMID:28120208
Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease., PMID:28059793
Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase., PMID:27608597
[Association of gene polymorphisms with the susceptibility of schizophrenia in Han Chinese population]., PMID:27337794
Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice., PMID:27240539
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments., PMID:27059953
Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity., PMID:26887941
The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease., PMID:26738354
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)., PMID:26678856
Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues., PMID:26662803
By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice., PMID:26293690
Structural basis of human γ-secretase assembly., PMID:25918421
[Comparative transcriptome pairwise analysis of spontaneously transformed multipotent stromal cells from human adipose tissue]., PMID:25711018
CSF Presenilin-1 complexes are increased in Alzheimer's disease., PMID:24252417
Γ-secretase components as predictors of breast cancer outcome., PMID:24223915
Toward the structure of presenilin/γ-secretase and presenilin homologs., PMID:24099007
For research use only. Not for human or drug use.
