Catalog No.
YHB04901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser22-Ser120
Predicted molecular weight
22.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60931
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTNS, Cystinosin
Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress., PMID:40505348
Emerging therapeutic strategies for cystinosis., PMID:40469087
Untangling Traffic Jams: RAB11FIP4 Orchestrates Cellular Recovery in Cystinosis., PMID:40395987
Computational prediction of deleterious nonsynonymous SNPs in the CTNS gene: implications for cystinosis., PMID:40375073
Long-term outcomes in nephropathic cystinosis: a review., PMID:40369127
Inhibition of Tyrosinase and Melanogenesis by Carboxylic Acids: Mechanistic Insights and Safety Evaluation., PMID:40286213
Transplantation of Wild-Type Hematopoietic Stem and Progenitor Cells Improves Disease Phenotypes in a Mucopolysaccharidosis IIIC Mouse Model., PMID:40126917
Novel mechanism for tubular injury in nephropathic cystinosis., PMID:40111391
Cystinosin is involved in Na+/H+ Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis., PMID:39990449
Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis., PMID:39980044
Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1., PMID:39883854
Lysosomal reduced thiols are essential for mouse embryonic development., PMID:39764028
An Open-Label, Phase III Study to Assess the Efficacy and Safety of Cysteamine Ophthalmic Solution 0.55% in Japanese Cystinosis Patients., PMID:39618989
Cystinosis metabolic bone disease: inflammatory profile in human peripheral blood mononuclear cells and derived osteoclasts., PMID:39540998
Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis., PMID:39530101
ZenoSWATH DIA proteomics and clustering analysis of the effect of cysteamine at the cellular level in cystinotic fibroblasts., PMID:39504626
The Value of Biomarkers in Major Cardiovascular Surgery Necessitating Cardiopulmonary Bypass., PMID:39484111
Single phage proteins sequester signals from TIR and cGAS-like enzymes., PMID:39478223
Reconstitution of Rab11-FIP4 Expression Rescues Cellular Homeostasis in Cystinosis., PMID:39434668
Mitigative role of cysteamine against unilateral renal reperfusion injury in Wistar rats., PMID:39372204
Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy., PMID:39294696
Molecular characterization of clinically isolated Pseudomonas aeruginosa with varying resistance to ceftazidime-avibactam and ceftolozane-tazobactam collected as a part of the ATLAS global surveillance program from 2020 to 2021., PMID:39254297
A systematic review and meta-analysis evaluating the association of high sensitivity troponin levels with outcomes in patients with stable coronary artery disease., PMID:39235073
Leptin signalling altered in infantile nephropathic cystinosis-related bone disorder., PMID:39210624
Implications of Age for the Diagnostic and Prognostic Value of Cardiac Troponin T and I., PMID:39119905
Long-term effects of luteolin in a mouse model of nephropathic cystinosis., PMID:39096619
Cystinosis-Associated Metabolic Bone Disease Across Ages and CKD Stages 1 to 5D/T., PMID:39049782
Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread., PMID:38990725
Associations Between Biomarkers of Myocardial Injury and Systemic Inflammation and Risk of Incident Ventricular Arrhythmia., PMID:38904572
Cortical impairment and reduced muscle mass in children and young adults with nephropathic cystinosis., PMID:38864569
Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis., PMID:38633264
Residual Cystine Transport Activity for Specific Infantile and Juvenile CTNS Mutations in a PTEC-Based Addback Model., PMID:38607085
MFSD12 depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis., PMID:38545650
Lysosomal cystine accumulation activates mTOR signaling in cystinosis: are mTOR inhibitors the cure?, PMID:38519228
Gene editing improves endoplasmic reticulum-mitochondrial contacts and unfolded protein response in Friedreich's ataxia iPSC-derived neurons., PMID:38420191
Cardiac troponins and coronary artery calcium score: a systematic review., PMID:38336618
Extrarenal complications of cystinosis., PMID:38127152
Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides., PMID:38103556
Neurologic involvement in cystinosis: Focus on brain lesions and new evidence of four-repeat (4R-) Tau immunoreactivity., PMID:38101161
Event-related potential (ERP) evidence for visual processing differences in children and adults with cystinosis (CTNS gene mutations)., PMID:38087330
Studies with Human-Induced Pluripotent Stem Cells Reveal That CTNS Mutations Can Alter Renal Proximal Tubule Differentiation., PMID:38069326
Impact of compliance to oral cysteamine treatment on the costs of Kidney failure in patients with nephropathic cystinosis in the United Kingdom., PMID:38031005
CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy., PMID:38018843
Cystinosis: Status of research and treatment in India and the world., PMID:38018544
Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis., PMID:38016974
Single phage proteins sequester TIR- and cGAS-generated signaling molecules., PMID:38014003
Functional analysis of the CTNS gene exonic variants predicted to affect splicing., PMID:38009794
Omic Studies on In Vitro Cystinosis Model: siRNA-Mediated CTNS Gene Silencing in HK-2 Cells., PMID:37949358
The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules., PMID:37940765
For research use only. Not for human or drug use.
