Catalog No.
YHK94801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro200-Ser411
Predicted molecular weight
25.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TAX9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GSDML, p16, GSDMB-NT, GSDMB-CT, Gasdermin-like protein, GSDMB, p30, Gasdermin-B
Unveiling the role of gasdermin B in cancer and inflammatory disease: from molecular mechanisms to therapeutic strategies., PMID:40452932
Identification of programmed cell death-related genes and construction of a prognostic model in oral squamous cell carcinoma using single-cell and transcriptome analysis., PMID:40346375
Gasdermin B modulates intestinal epithelial homeostasis via regulating hyperactive unfolded protein response in Crohn's disease., PMID:39831701
Biological characteristics, immune infiltration and drug prediction of PANoptosis related genes and possible regulatory mechanisms in inflammatory bowel disease., PMID:39814753
Comprehensive analyses reveal the promising value of gasdermins as prognostic biomarkers and immunotherapeutic targets in head and neck squamous cell carcinoma., PMID:39807507
Diagnostic and prognostic value of the gasdermins in gastric cancer., PMID:39607202
Identification of gasdermin B function in the progression of renal clear cell carcinoma by a pan-cancer analysis., PMID:39589674
Immune-oncology targets and therapeutic response of cell pyroptosis-related genes with prognostic implications in neuroblastoma., PMID:39548036
GSDMB interacts with IGF2BP1 to suppress colorectal cancer progression by modulating DUSP6-ERK pathway., PMID:39353395
Sequence variants influencing the regulation of serum IgG subclass levels., PMID:39277589
Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis., PMID:39264808
Seneca Valley virus circumvents Gasdermin A-mediated inflammation by targeting the pore-formation domain for cleavage., PMID:39207099
Association of CD8+TILs co-expressing granzyme A and interferon-γ with colon cancer cells in the tumor microenvironment., PMID:39030523
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis., PMID:39029644
PGAP3 regulates human bronchial epithelial cell mRNAs present in asthma and respiratory virus reference data sets., PMID:39006429
4-Octyl itaconate blocks GSDMB-mediated pyroptosis and restricts inflammation by inactivating granzyme A., PMID:38982510
Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes., PMID:38982180
Correlation of gasdermin B staining patterns with prognosis, progression, and immune response in colorectal cancer., PMID:38711020
Gasdermin B (GSDMB) in psoriatic patients-a preliminary comprehensive study on human serum, urine and skin., PMID:38693919
GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma., PMID:38674355
Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation., PMID:38514093
Caspase-1 activates gasdermin A in non-mammals., PMID:38497531
Assessment the value of Pyroptosis-Associated Gasdermin family genes in hepatocellular carcinoma: A Multi-Omics Comprehensive Analysis., PMID:38434972
Monkeypox virus infection of human astrocytes causes gasdermin B cleavage and pyroptosis., PMID:38346199
Novel Role of the GSDMB/IFNG Axis in Childhood Asthma., PMID:38300150
Genetics of preschool wheeze and its progression to childhood asthma., PMID:38284918
Relevance of pyroptosis-associated genes in nasopharyngeal carcinoma diagnosis and subtype classification., PMID:38282154
Protein corona exacerbated inflammatory response in macrophages elicited by CdTe quantum dots., PMID:38246246
To die or not to die: Gasdermins in intestinal health and disease., PMID:38232665
Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases., PMID:38225586
Pyroptosis-Related Subtypes Predict the Response of Clear Cell Renal Cell Carcinoma to Targeted Therapy., PMID:38179741
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma., PMID:38064241
Structural and functional insights into GSDMB isoforms complex roles in pathogenesis., PMID:38037340
Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer., PMID:37997534
Caspase-1 activates gasdermin A in non-mammals., PMID:37987010
Inetetamab, a novel anti-HER2 monoclonal antibody, exhibits potent synergistic anticancer effects with cisplatin by inducing pyroptosis in lung adenocarcinoma., PMID:37705753
Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence., PMID:37620327
Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage., PMID:37591921
Anti-PD-1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2-Positive Gastric Cancer through Gasdermin B-Cleavage Induced Pyroptosis., PMID:37587833
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis., PMID:37462807
Pyroptosis-induced inflammation and tissue damage., PMID:37352727
The Pyroptotic and Nonpyroptotic Roles of Gasdermins in Modulating Cancer Progression and Their Perspectives on Cancer Therapeutics., PMID:37258998
Role of Gasdermin E in the Biogenesis of Apoptotic Cell-Derived Exosomes., PMID:37163338
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis., PMID:37115914
Inducing Pyroptosis via Gasdermin B and Gasdermin E Cleavage., PMID:37074648
Systematic pan-cancer analysis identifies gasdermin B as an immunological and prognostic biomarker for kidney renal clear cell carcinoma., PMID:37064151
Regulating GSDMB pore formation: to ignite or inhibit?, PMID:37041290
Structural mechanisms for regulation of GSDMB pore-forming activity., PMID:36991125
Structural basis for GSDMB pore formation and its targeting by IpaH7.8., PMID:36991122
Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children., PMID:36967681
For research use only. Not for human or drug use.
