Catalog No.
YHK20401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys366
Predicted molecular weight
42.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WTS6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7
SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation., PMID:40275362
Lysine methyltransferase SETD7 in cancer: functions, molecular mechanisms and therapeutic implications., PMID:40232640
SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis., PMID:40098010
Targeting SETD7 Rescues Diabetes-Induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin-3G., PMID:40014026
Retarding human adipose-derived MSCs senescence and promoting tendon repair using cell sheet engineering with a histone methyltransferase inhibitor., PMID:39979391
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression., PMID:39862337
Interaction Between YTH Domain-Containing Family Protein 2 and SET Domain-Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage., PMID:39789715
Exploring the efficacy of (R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation., PMID:39776548
SETD7 promotes LC3B methylation and degradation in ovarian cancer., PMID:39725038
SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma., PMID:38904013
Promoter hypermethylation-induced downregulation of ITGA7 promotes colorectal cancer proliferation and migration by activating the PI3K/AKT/NF-κB pathway., PMID:38885843
5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential., PMID:38827317
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development., PMID:38812048
Association of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma and Skin Carotenoid Concentrations in Adults Provided a Lycopene-Rich Juice., PMID:38797482
Unravelling the molecular mechanistic pathway underlying the anticancer effects of kaempferol in colorectal cancer: a reverse pharmacology network approach., PMID:38795259
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7., PMID:38670954
Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells., PMID:38602631
Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients., PMID:38553774
Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma., PMID:38520914
Lysine Methylation-Dependent Proteolysis by the Malignant Brain Tumor (MBT) Domain Proteins., PMID:38396925
Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner., PMID:38365969
Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors., PMID:38213775
Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers., PMID:38088751
Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis., PMID:38049011
Methyltransferase Set7/9 controls PARP1 expression and regulates cisplatin response of breast cancer cells., PMID:38043199
ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma., PMID:38018874
(R)-PFI-2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7., PMID:37872124
SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A., PMID:37870957
Inhibiting SETD7 methyl-transferase activity impairs differentiation, lipid metabolism and lactogenesis in mammary epithelial cells., PMID:37723127
M2 Macrophage-Derived Extracellular Vesicles Containing MicroRNA-501-3p Promote Colon Cancer Progression Through the SETD7/DNMT1/SOCS3 Axis., PMID:37695661
Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer., PMID:37682707
Identification of differentially expressed miRNAs and mRNAs associated with the regulation of breast cancer via in silico and in vitro methods., PMID:37655273
Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascade., PMID:37564199
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1., PMID:37549269
Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy-hippocampal sclerosis patients may limit the seizure outcomes., PMID:37432566
SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation., PMID:37286143
Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis., PMID:37275887
PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance., PMID:37235656
Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response., PMID:37215983
Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors., PMID:37055532
DDB1 regulates the activation-induced apoptosis of T cells via downregulating the expression of histone methyltransferase SETD7., PMID:37043057
Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells., PMID:36841324
SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis., PMID:36822329
[Research Progress of Role and Mechanism of SETD7 in Tumor Occurrence
and Progression]., PMID:36792079
SETD7 Expression Is Associated with Breast Cancer Survival Outcomes for Specific Molecular Subtypes: A Systematic Analysis of Publicly Available Datasets., PMID:36551516
Investigation of in vitro histone H3 glycosylation using H3 tail peptides., PMID:36357422
Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity., PMID:36209579
The role of SET domain containing lysine methyltransferase 7 in tumorigenesis and development., PMID:36101480
SETD7 methyltransferase is a key druggable target for effective cardioprotection from myocardial ischaemic injury., PMID:36056836
The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer., PMID:35812730
For research use only. Not for human or drug use.
