Catalog No.
YHH05501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser464-Glu552
Predicted molecular weight
22.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15276
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RABPT5, RABEP1, Rabaptin-4, RABPT5A, Rab GTPase-binding effector protein 1, Renal carcinoma antigen NY-REN-17, RAB5EP, Rabaptin-5alpha, Rabaptin-5
RABEP1 amplifies front signaling in neutrophil migration., PMID:40463167
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes., PMID:40448432
Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies., PMID:39655660
LPI-GPR55 promotes endothelial cell activation and inhibits autophagy through inducing LINC01235 expression., PMID:39316662
Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus., PMID:37428306
Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer's Disease., PMID:36776048
The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation., PMID:36008957
RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis., PMID:35000547
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease., PMID:34732252
His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation., PMID:34657963
Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head., PMID:34163523
Cobalt chloride-simulated hypoxia elongates primary cilia in immortalized human retina pigment epithelial-1 cells., PMID:33823365
Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants., PMID:32574725
Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis., PMID:31139847
Abnormalities in endothelial form of nitric oxide synthase is pathogenic in limited cutaneous systemic sclerosis., PMID:30980594
Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., PMID:28694205
Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling., PMID:27027798
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5., PMID:26680696
ITSN2L Interacts with and Negatively Regulates RABEP1., PMID:26633357
Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation., PMID:26430212
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer., PMID:26074449
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism., PMID:25405894
Characterization of Rabaptin-5 γ isoform., PMID:25385014
Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections., PMID:25161316
HDAC6 sustains growth stimulation by prolonging the activation of EGF receptor through the inhibition of rabaptin-5-mediated early endosome fusion in gastric cancer., PMID:25111897
Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5., PMID:24957337
Gender-associated expression of tumor markers and a small gene set in breast carcinoma., PMID:24656773
HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia., PMID:24378640
VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages., PMID:23271971
Co-expression of genes with estrogen receptor-α and progesterone receptor in human breast carcinoma tissue., PMID:25436697
PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5., PMID:22975325
Distinct and overlapping roles for AP-1 and GGAs revealed by the "knocksideways" system., PMID:22902756
Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking., PMID:22841712
Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics., PMID:21271679
Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis., PMID:20169068
Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Behçet's disease., PMID:19796537
Perturbation of vacuolar maturation promotes listeriolysin O-independent vacuolar escape during Listeria monocytogenes infection of human cells., PMID:19500109
Regulation of endocytosis via the oxygen-sensing pathway., PMID:19252501
Rabaptin-5 regulates receptor expression and functional activation in mast cells., PMID:18698003
Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease., PMID:17961730
Structural basis for Rab GTPase activation by VPS9 domain exchange factors., PMID:17450153
Dimerization properties of Rabaptin-5 and its isoforms., PMID:17223781
TIP47 is a key effector for Rab9 localization., PMID:16769818
Analysis of the interaction between GGA1 GAT domain and Rabaptin-5., PMID:16473621
Expression and properties of the Rab4, Rabaptin-5alpha, AP-1 complex in endosomal recycling., PMID:16473617
Membrane recruitment of effector proteins by Arf and Rab GTPases., PMID:16289847
Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: possible role on cognitive defect seen in PKU., PMID:15863237
Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins., PMID:15701688
Neurocrescin is specifically cleaved after the sequence DESD in a caspase-3-independent manner., PMID:15672675
For research use only. Not for human or drug use.
