Catalog No.
YHA72701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln179-Lys213
Predicted molecular weight
16.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43613
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hypocretin receptor type 1, Ox1-R, Ox1R, Ox-1-R, Orexin receptor type 1, HCRTR1
Mitigation of learning and memory impairment caused by acute total sleep deprivation through OX1R/OX2R-mediated hippocampal neurogenesis in rats., PMID:40318707
Expression and purification of an activated orexin receptor 1- G-protein complex., PMID:39761735
The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data., PMID:39733410
Bioinformatic analysis of neuropeptide related genes in patients diagnosed with invasive breast carcinoma., PMID:39437604
Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN)., PMID:39300279
The restraint stress-induced antinociceptive effects decreased by antagonism of both orexin receptors within the CA1 region of the hippocampus., PMID:39180799
Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model., PMID:39119889
Hypocretin in the nucleus accumbens shell modulates social approach in female but not male California mice., PMID:39117901
A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation., PMID:39056112
Restraint stress-induced antinociceptive effects in acute pain: Involvement of orexinergic system in the nucleus accumbens., PMID:38960330
Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease., PMID:38892431
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice., PMID:38886189
Trigeminal nerve electrical stimulation attenuates early traumatic brain injury through the TLR4/NF-κB/NLRP3 signaling pathway mediated by orexin-A/OX1R system., PMID:38713160
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control., PMID:38123729
Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell., PMID:37572990
Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behaviour in alcohol-dependent rats., PMID:36537731
A molecular network map of orexin-orexin receptor signaling system., PMID:36480100
Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats., PMID:36470538
Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction., PMID:36411386
Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala., PMID:35724928
Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo., PMID:35338110
Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior., PMID:35279280
Discovery of the Potential Novel Pharmacodynamic Substances From Zhi-Zi-Hou-Po Decoction Based on the Concept of Co-Decoction Reaction and Analysis Strategy., PMID:35095537
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain., PMID:34718063
Role of Hypocretin in the Medial Preoptic Area in the Regulation of Sleep, Maternal Behavior and Body Temperature of Lactating Rats., PMID:34500018
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity., PMID:34475397
Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study., PMID:34472713
Similar role of mPFC orexin-1 receptors in the acquisition and expression of morphine- and food-induced conditioned place preference in male rats., PMID:34450116
Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation., PMID:34439801
Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury., PMID:34358627
Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists., PMID:34101446
Wakefulness-Promoting Effects of Lateral Hypothalamic Area-Deep Brain Stimulation in Traumatic Brain Injury-Induced Comatose Rats: Upregulation of α1-Adrenoceptor Subtypes and Downregulation of Gamma-Aminobutyric Acid β Receptor Expression Via the Orexins Pathway., PMID:34062300
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases., PMID:34052813
Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain., PMID:33974073
Orexin-A differentially modulates inhibitory and excitatory synaptic transmission in rat inner retina., PMID:33582153
Genetic determinants of daytime napping and effects on cardiometabolic health., PMID:33568662
Orexin-A Intensifies Mouse Pupillary Light Response by Modulating Intrinsically Photosensitive Retinal Ganglion Cells., PMID:33536197
Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking., PMID:33420199
Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510., PMID:33361602
Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats., PMID:33229892
Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway., PMID:33212156
Median Nerve Stimulation as a Nonpharmacological Approach to Bypass Analgesic Tolerance to Morphine: A Proof-of-Concept Study in Mice., PMID:33069869
Nucleus accumbens shell Orexin-1 receptors are not needed for single-bottle limited daily access alcohol intake in C57BL/6 mice., PMID:32987129
A novel phosphorylation site on orexin receptor 1 regulating orexinA-induced GRK2-biased signaling., PMID:32827691
Orexin A injection into the ventral medial prefrontal cortex induces antidepressant-like effects: Possible involvement of local Orexin-1 and Trk receptors., PMID:32827568
Evaluation of the relationship between the gene expression level of orexin-1 receptor in the rat blood and prefrontal cortex, novelty-seeking, and proneness to methamphetamine dependence: A candidate biomarker., PMID:32668268
Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender., PMID:32652147
Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats., PMID:32643036
The rostral ventromedial medulla orexin 1 receptors and extracellular signal-regulated kinase in hippocampus are involved in modulation of anxiety behavior induced by dental pulp nociception in adult male rats., PMID:32474210
Assessing established BMI variants for a role in nighttime eating behavior in robustly phenotyped Southwestern American Indians., PMID:32398872
For research use only. Not for human or drug use.
