Catalog No.
YHB12501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly124
Predicted molecular weight
16.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75190
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HHDJ1, Heat shock protein J2, MRJ, HSJ-2, HSJ2, MSJ-1, DnaJ homolog subfamily B member 6, DNAJB6, MSJ1
A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones., PMID:40450039
Evaluation of aggrephagy markers in myofibrillar myopathies., PMID:40413523
Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping., PMID:40412548
A survey on mutation spectrum in Iranian patients with limb-girdle muscular dystrophies., PMID:40361203
Cardiomyocyte-specific activation of the sarcomere-localized Dnajb6b chaperone causes cardiomyopathy and heart failure through upregulated sarcoplasmic reticulum stress., PMID:40360088
The Role of α-Synuclein-DNAJB6b Coaggregation in Amyloid Suppression., PMID:40304428
Mutational and clinical spectrum of myofibrillar myopathy in one center from China., PMID:39973468
Expression analysis of molecular chaperones associated with disaggregation complex in rotenone-induced Parkinsonian rat model., PMID:39952347
On the thermal and chemical stability of DNAJB6b and its globular domains., PMID:39938325
HSPA4 Expression is Correlated with Melanoma Cell Proliferation, Prognosis, and Immune Regulation., PMID:39629045
Circular RNA hsa_circ_0008726 Targets the hsa-miR-206-3p/KLF4 Axis to Modulate 4,4'-Methylene Diphenyl Diisocyanate-Glutathione Conjugate-Induced Chemokine Transcription in Macrophages., PMID:39451243
Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma., PMID:39448713
Abnormally High Expression of DNAJB6 Accelerates Malignant Progression of Lung Adenocarcinoma., PMID:39335495
DNAJB6 is expressed in neurons and oligodendrocytes of the human brain., PMID:39228066
Intrinsic Disorder in the Host Proteins Entrapped in Rabies Virus Particles., PMID:38932209
Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model., PMID:38767906
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State., PMID:38640082
Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model., PMID:38621658
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity., PMID:38508190
Defining clinical endpoints in limb girdle muscular dystrophy: a GRASP-LGMD study., PMID:38491364
Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription., PMID:38244155
The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation., PMID:38110916
The expression, function, and network regulation of circDNAJB6 in chicken macrophages under lipopolysaccharide (LPS) stimulation., PMID:37951323
DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones., PMID:37923706
Uncovering key molecular mechanisms in the early and late-stage of papillary thyroid carcinoma using association rule mining algorithm., PMID:37917782
miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy., PMID:37894814
Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates., PMID:37845327
Detergent-insoluble PFN1 inoculation expedites disease onset and progression in PFN1 transgenic rats., PMID:37817804
The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation., PMID:37797698
Combined sequence and copy number analysis improves diagnosis of limb girdle and other myopathies., PMID:37688281
Heat shock induces alternative polyadenylation through dynamic DNA methylation-regulated chromatin looping., PMID:37662379
MUC1 promotes lymph node metastasis in esophageal squamous cell carcinoma by downregulating DNAJB6 expression., PMID:37584547
DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1., PMID:37346979
Preparation of chaperone-loaded neural stem cell-derived extracellular vesicles to reduce protein aggregation in Huntington's disease cellular models., PMID:36861837
DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells., PMID:36723955
The roles of HSP40/DNAJ protein family in neurodegenerative diseases., PMID:36581576
Extracellular chaperone networks and the export of J-domain proteins., PMID:36581212
Development of novel DNAJB6-KIAA1522-p-mTOR three-protein prognostic prediction models for CRC., PMID:36571988
Human J-Domain Protein DnaJB6 Protects Yeast from [PSI+] Prion Toxicity., PMID:36552355
DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis., PMID:36432676
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis., PMID:36302971
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene., PMID:36255053
A novel long non-coding RNA, lnc-RNU12, influences the T-cell cycle via c-JUN and CCNL2 in rheumatoid arthritis., PMID:36165706
Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors., PMID:35931773
Identification of Key Genes as Early Warning Signals of Acute Myocardial Infarction Based on Weighted Gene Correlation Network Analysis and Dynamic Network Biomarker Algorithm., PMID:35795669
Identification of immunity- and ferroptosis-related genes for predicting the prognosis of serous ovarian cancer., PMID:35777713
Microsecond Backbone Motions Modulate the Oligomerization of the DNAJB6 Chaperone., PMID:38505697
LGMD D2 TNPO3-Related: From Clinical Spectrum to Pathogenetic Mechanism., PMID:35309568
Microsecond Backbone Motions Modulate the Oligomerization of the DNAJB6 Chaperone., PMID:35247211
A female carrier of spinal and bulbar muscular atrophy diagnosed with DNAJB6-related distal myopathy., PMID:35165376
For research use only. Not for human or drug use.
