Catalog No.
YHF98702
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly461-Ser581
Predicted molecular weight
15.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q03252
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LMN2, LMNB2, Lamin-B2
Bone mineral loss and risk of atrial fibrillation: A multicohort study., PMID:40504860
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma., PMID:40483310
NOP2-Mediated m5C Methylation Modification of LMNB2 mRNA Facilitates Colorectal Cancer Progression., PMID:40366008
Extracellular transfer of HuR promotes acquired cisplatin resistance in esophageal cancer cells., PMID:40269355
TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer., PMID:40159489
Nuclear translocation of the LINE-1 encoded ORF1 protein alters nuclear envelope integrity in human neurons., PMID:40157412
A high throughput, high content screen for non-toxic small molecules that reduce levels of the nuclear lamina protein, Lamin B1., PMID:40025114
Homozygous loss of function variant in LMNB2 gene causes major brain malformation and perinatal death., PMID:40011009
Identification of Potential Therapeutic Targets for Sensorineural Hearing Loss and Evaluation of Drug Development Potential Using Mendelian Randomization Analysis., PMID:40001646
An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants., PMID:39910058
Nuclear blebs are associated with destabilized chromatin-packing domains., PMID:39878045
Role of lamins in cellular physiology and cancer., PMID:39843134
Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue., PMID:39838347
Distinct structural and functional heterochromatin partitioning of lamin B1 and lamin B2 revealed using genome-wide nicking enzyme epitope targeted DNA sequencing., PMID:39817518
Comprehensive analysis of LMNB2 in pan-cancer and identification of its biological role in sarcoma., PMID:39774004
Divergent Contribution of Cytoplasmic Actins to Nuclear Structure of Lung Cancer Cells., PMID:39769373
Impairment of Intermediate Filament Expression Reveals Impact on Cell Functions Independent from Keratinocyte Transformation., PMID:39682709
Impact of Nuclear Peripheral Chromatin Lamin LMNB1 Gene in the Proliferation and Migration of Glioma Cells., PMID:39636549
Pan-cancer TCGA analysis reveals the potential involvement of B-type lamins in dysregulating chromosome segregation in human cancer., PMID:39592474
Decreased DNA density is a better indicator of a nuclear bleb than lamin B loss., PMID:39501901
Long-Axial-Range Double-Helix Point Spread Functions for 3D Volumetric Super-Resolution Imaging., PMID:39501549
Mouse polyomavirus infection induces lamin reorganisation., PMID:39288210
Altered expression and localization of nuclear envelope proteins in a prostate cancer cell system., PMID:39115711
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation., PMID:39103492
Aberrant migration features in primary skin fibroblasts of Huntington's disease patients hold potential for unraveling disease progression using an image based machine learning tool., PMID:39096606
Structural Variants at the LMNB1 Locus: Deciphering Pathomechanisms in Autosomal Dominant Adult-Onset Demyelinating Leukodystrophy., PMID:39078102
Annexin A11 mutations are associated with nuclear envelope dysfunction in vivo and in human tissues., PMID:38989900
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer., PMID:38964523
Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina., PMID:38917015
SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction., PMID:38870534
The potential role of RNA sequencing in diagnosing unexplained insensitivity to conventional chemotherapy in pediatric patients with B-cell acute lymphoblastic leukemia., PMID:38811988
LMNB1/CDKN1A Signaling Regulates the Cell Cycle and Promotes Hepatocellular Carcinoma Progression., PMID:38778606
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism., PMID:38519987
Protein kinase C activity modulates nuclear Lamin A/C dynamics in HeLa cells., PMID:38493209
Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity., PMID:38485766
Upregulated expression of lamin B receptor increases cell proliferation and suppresses genomic instability: implications for cellular immortalization., PMID:38462947
UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury., PMID:38308641
ENPP1 inhibits the transcription activity of the hepatitis B virus pregenomic promoter by upregulating the acetylation of LMNB1., PMID:38265511
Lamins: The backbone of the nucleocytoskeleton interface., PMID:38262116
PIGB maintains nuclear lamina organization in skeletal muscle of Drosophila., PMID:38261271
Lamin B1: a novel biomarker in adult and pediatric adrenocortical carcinoma., PMID:38224097
The Functions of Pt-DIC and Pt-Lamin B in Spermatogenesis of Portunus trituberculatus., PMID:38203284
The atrial and ventricular myocardial proteome of end-stage lamin heart disease., PMID:38090549
The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases., PMID:37806292
Nuclear lamin facilitates collective border cell invasion into confined spaces in vivo., PMID:37695420
Transient naive reprogramming corrects hiPS cells functionally and epigenetically., PMID:37587336
Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study., PMID:37434081
Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes., PMID:37347778
Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes., PMID:37229920
Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture., PMID:37212777
For research use only. Not for human or drug use.
