Catalog No.
YHG83501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp35-Ala203
Predicted molecular weight
20.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14576
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HUC, Hu-antigen C, HuC, ELAV-like protein 3, ELAVL3, Paraneoplastic cerebellar degeneration-associated antigen, PLE21, Paraneoplastic limbic encephalitis antigen 21
Molecular Subtyping Based on Hippocampal Cryptic Exon Burden Reveals Proteome-wide Changes Associated with TDP-43 Pathology across the Spectrum of LATE and Alzheimer's Disease., PMID:40501554
Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity., PMID:40172026
ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases., PMID:40000387
Detection of Mitotic Neuroblasts Provides Additional Evidence of Steady-State Neurogenesis in the Adult Small Intestinal Myenteric Plexus., PMID:39933921
Multi-omics revealed that ELAVL3 regulates MYCN in neuroblastoma via immunogenic cell death: Risk stratification and experimental research., PMID:39486730
Adverse Outcomes Following Exposure to Perfluorooctanesulfonamide (PFOSA) in Larval Zebrafish (Danio rerio): A Neurotoxic and Behavioral Perspective., PMID:39453143
Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy., PMID:38814471
Post-transcriptional dysregulation in autism, schizophrenia, and bipolar disorder., PMID:38807376
The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer., PMID:38016952
4-Methylbenzylidene camphor induced neurobehavioral toxicity in zebrafish (Danio rerio) embryos., PMID:38008201
Interactions between the lipidome and genetic and environmental factors in autism., PMID:37076741
An inducible expression system for the manipulation of autophagic flux in vivo., PMID:36310368
Amyotrophic lateral sclerosis with TDP-43 abnormalities exhibiting globular glial tau inclusions in frontotemporal lobes and pallido-nigral system., PMID:36003035
Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis., PMID:35816841
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis., PMID:34618203
Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of triphenyl phosphate in zebrafish larvae., PMID:34562708
Evaluation of the acute toxicity and neurodevelopmental inhibition of perfluorohexanoic acid (PFHxA) in zebrafish embryos., PMID:34478978
Anaplastic Lymphoma Kinase Overexpression Is Associated with Aggressive Phenotypic Characteristics of Ovarian High-Grade Serous Carcinoma., PMID:34214505
Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype., PMID:34061953
MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity., PMID:34031238
IGFBPs mediate IGF-1's functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids., PMID:33442906
Developmental neurotoxicity of low concentrations of bisphenol A and S exposure in zebrafish., PMID:33182117
Developmental neurotoxicity and toxic mechanisms induced by olaquindox in zebrafish., PMID:33111391
Identification of potential biomarkers and candidate small molecule drugs in glioblastoma., PMID:32874133
8:8 Perfluoroalkyl phosphinic acid affects neurobehavioral development, thyroid disruption, and DNA methylation in developing zebrafish., PMID:32474277
Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding of the Her6 oscillator., PMID:32395844
Titanium dioxide nanoparticles enhanced thyroid endocrine disruption of pentachlorophenol rather than neurobehavioral defects in zebrafish larvae., PMID:32217413
The neural ELAVL protein HuB enhances endogenous proto-oncogene activation., PMID:31358321
RNA-Binding Proteins HuB, HuC, and HuD are Distinctly Regulated in Dorsal Root Ganglia Neurons from STZ-Sensitive Compared to STZ-Resistant Diabetic Mice., PMID:31013625
A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons., PMID:30755067
Choice of Alternative Polyadenylation Sites, Mediated by the RNA-Binding Protein Elavl3, Plays a Role in Differentiation of Inhibitory Neuronal Progenitors., PMID:30687010
HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors., PMID:30468801
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish., PMID:30411440
Optical measurement of neuronal activity in the developing cerebellum of zebrafish using voltage-sensitive dye imaging., PMID:30192301
Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae., PMID:30096480
Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice., PMID:29626565
Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG., PMID:29614249
Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence., PMID:29479825
Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis., PMID:29453425
Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio)., PMID:29432853
Elavl3 is essential for the maintenance of Purkinje neuron axons., PMID:29426875
A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus., PMID:28891045
Neuronal connections of the central amygdalar nucleus with refeeding-activated brain areas in rats., PMID:28852859
Transcriptomic profile analysis of mouse neural tube development by RNA-Seq., PMID:28691208
Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development., PMID:28359144
Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons., PMID:28188691
Data on isoaspartylation of neuronal ELAVL proteins., PMID:27924291
The acute inhibition of enteric glial metabolism with fluoroacetate alters calcium signaling, hemichannel function, and the expression of key proteins., PMID:27784805
Subthalamic nucleus volumes are highly consistent but decrease age-dependently-a combined magnetic resonance imaging and stereology approach in humans., PMID:27726278
L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish., PMID:26889968
For research use only. Not for human or drug use.
