Catalog No.
YHK92101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr67-His343
Predicted molecular weight
32.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UB35
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Formyltetrahydrofolate synthetase, MTHFD1L, Monofunctional C1-tetrahydrofolate synthase, mitochondrial, FTHFSDC1
Vitamin B-related Gene Polymorphisms and Cardiovascular Disease., PMID:35346016
Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice., PMID:35011003
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers., PMID:34908119
Serine catabolism generates liver NADPH and supports hepatic lipogenesis., PMID:34845393
Oncogenic Ras expression increases cellular formate production., PMID:34550462
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy., PMID:34544865
Association between SNPs and hepatotoxicity in patients with primary central nervous system lymphoma on high-dose methotrexate therapy., PMID:34254644
Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization mass spectrometry imaging., PMID:33829277
Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma., PMID:33605411
Arbutin suppresses osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway., PMID:33146000
MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway., PMID:32456526
Sequence variation at the MTHFD1L-AKAP12 and FOPNL loci does not influence multiple myeloma survival in Sweden., PMID:31363079
hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles., PMID:31147722
L-methylfolate Augmentation to Antidepressants for Adolescents with Treatment-Resistant Depression: A Case Series., PMID:31058543
Formate Supplementation May Prevent Some Neural Tube Defects that Prove Resistant to Folic Acid: Supplementation with formate rescued normal neural tube closure in more than three quarters of the embryos of novel folic acid-resistant neural tube defect mouse models., PMID:30136438
EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis., PMID:29873416
Molecular cloning and characterization of C1 tetrahydrofolate (C1-THF) synthase in Bombyx mori, silkworm., PMID:29660516
Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos., PMID:29483189
Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China., PMID:29392422
The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma., PMID:29171320
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD., PMID:29142318
Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects., PMID:28865601
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma., PMID:28394261
MTHFR and MTHFD1 gene polymorphisms are not associated with pseudoexfoliation syndrome in South Indian population., PMID:28299500
Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis., PMID:28265077
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development., PMID:27707701
Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors., PMID:27597531
Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression., PMID:26926881
The genetic background of climacteric symptoms in women during menopause., PMID:29734534
MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice., PMID:26408344
Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome., PMID:25809277
Metabolism gene signatures and surgical site infections in abdominal surgery., PMID:25599917
[G894T (NOS3) and G1958A (MTHFD1) gene polymorphisms and risk of ischemic heart disease in Yucatan, Mexico]., PMID:25304051
Mitochondrial one-carbon metabolism and neural tube defects., PMID:24985542
Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues., PMID:24733394
Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China., PMID:24668664
Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients., PMID:24618918
An NTD-associated polymorphism in the 3' UTR of MTHFD1L can affect disease risk by altering miRNA binding., PMID:24123340
A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development., PMID:23704330
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice., PMID:23267094
Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland., PMID:22520921
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice., PMID:22378735
Replication of the MTHFD1L gene association with late-onset Alzheimer's disease in a Northern Han Chinese population., PMID:22330827
Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study., PMID:22103680
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome., PMID:21957892
The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population., PMID:21741665
The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population., PMID:21383495
Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair., PMID:21193302
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis., PMID:21156972
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities., PMID:20885792
For research use only. Not for human or drug use.
