Catalog No.
YHK92001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser316-Cys409
Predicted molecular weight
22.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TB45
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DEPDC6, DEP domain-containing protein 6, DEP domain-containing mTOR-interacting protein, DEPTOR
Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation., PMID:40496889
[Transcriptomic analysis of suspended Vero cells and reduction of cellular autophagy by epidermal growth factor]., PMID:40328724
Muscle-Derived Small Extracellular Vesicles Mediate Exercise-Induced Cognitive Protection in Chronic Cerebral Hypoperfusion., PMID:40271743
DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase., PMID:40169856
Research progress on the regulation mechanism of DEPTOR expression and its role in tumorigenesis., PMID:40162510
Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells., PMID:40140647
Lentivirus-Mediated Trophoblast-Specific Deptor Knockdown Increases Transplacental System A and System L Amino Acid Transport and Fetal Growth in Mice., PMID:40133007
Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice., PMID:40042094
Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model., PMID:39982494
MCF7 breast cancer anabolic capacity reduced with CRISPR/Cas9-mediated stable overexpression of DEPTOR., PMID:39945739
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1., PMID:39533404
Exosomal miR-155-5p drives ibrutinib resistance in B-cell lymphoma., PMID:39260673
Novel insights into the mechanisms of seasonal cyclicity of testicles by proteomics and transcriptomics analyses in goose breeder lines., PMID:39190991
GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy., PMID:39180981
Bacterial ubiquitin ligases hijack the host deubiquitinase OTUB1 to inhibit MTORC1 signaling and promote autophagy., PMID:38818749
Effect of MYC and PARP Inhibitors in Ovarian Cancer Using an In Vitro Model., PMID:38677725
Identification and Validation of Genes Related to Macrophage Polarization and Cell Death Modes Under Mycobacterium tuberculosis Infection., PMID:38476473
Comparison of genomic alterations in Epstein-Barr virus-positive and Epstein-Barr virus-negative diffuse large B-cell lymphoma., PMID:38457199
miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus)., PMID:38365163
Optical genome mapping reveals balanced and unbalanced genetic changes associated with tumor-forming potential in an early-stage prostate cancer epithelial subline (M2205)., PMID:37902189
Molecular Characteristics of Everolimus-resistant Renal Cell Carcinoma Cells Generated by Continuous Exposure to Everolimus., PMID:37772579
PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated Glycolysis in Gastric Cancer., PMID:37469018
Metformin inhibits EV71‑induced pyroptosis by upregulating DEP domain‑containing mTOR‑interacting protein., PMID:37456175
Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus., PMID:37449268
Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus., PMID:37328520
Nutritional Supplementation and Exercise as Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases., PMID:37242219
Identification of key genes and molecular pathways in type 2 diabetes mellitus and polycystic ovary syndrome via bioinformatics analyses., PMID:37140276
Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability., PMID:37108437
DEPTOR as a novel prognostic marker inhibits the proliferation via deactivating mTOR signaling pathway in gastric cancer cells., PMID:37054772
Tumor necrosis factor α-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson's disease via the NFκB and mTOR pathways., PMID:37019273
UBXN2A, a Ubiquitin-Like Protein, Alters Proteins in mTORC2 Pathway., PMID:36889268
Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua., PMID:36685211
Dulaglutide Improves Gliosis and Suppresses Apoptosis/Autophagy Through the PI3K/Akt/mTOR Signaling Pathway in Vascular Dementia Rats., PMID:36571662
How GRAIL controls Treg function to maintain self-tolerance., PMID:36569931
The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells., PMID:36548081
The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model., PMID:36543126
DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice., PMID:36535626
Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk., PMID:36413936
Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR., PMID:36388131
Evaluation of mTOR Activity in COPD Patients with Emphysema., PMID:36377013
Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation., PMID:36090478
Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARγ and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes., PMID:36012680
DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR., PMID:35923131
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation., PMID:35609371
The ubiquitin ligase Nedd4-2 mediates the regulation of PepT2 by mTORC1 in bovine mammary epithelial cells., PMID:35601254
Autophagy Signaling by Neural-Induced Human Adipose Tissue-Derived Stem Cell-Conditioned Medium during Rotenone-Induced Toxicity in SH-SY5Y Cells., PMID:35457010
Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice., PMID:35305083
Molecular Signatures Correlated With Poor IVF Outcomes: Insights From the mRNA and lncRNA Expression of Endometriotic Granulosa Cells., PMID:35295989
Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation., PMID:35216969
The mixed blessing of AMPK signaling in Cancer treatments., PMID:35078427
For research use only. Not for human or drug use.
