Catalog No.
YHA48502
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Gly121
Predicted molecular weight
25.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15296
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
15-lipoxygenase 2, 15-LOX-B, 15-LOX-2, Linoleate 13-lipoxygenase 15-LOb, Arachidonate 15-lipoxygenase B, Polyunsaturated fatty acid lipoxygenase ALOX15B, ALOX15B, Arachidonate 15-lipoxygenase type II
Exploration potential sepsis-ferroptosis mechanisms through the use of CETSA technology and network pharmacology., PMID:40253433
The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals., PMID:40044044
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling., PMID:39843435
Structural and Functional Biology of Mammalian ALOX Isoforms with Particular Emphasis on Enzyme Dimerization and Their Allosteric Properties., PMID:39596127
Eicosanoid biosynthesizing enzymes in Prototheria., PMID:39389415
Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients., PMID:39259123
Structure of a model lipid membrane oxidized by human 15-lipoxygenase-2., PMID:39142138
Identification of Potential Ferroptosis Biomarkers and Analysis of Immune Cell Infiltration in Psoriasis Using Machine Learning., PMID:38835517
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities., PMID:38637408
Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation., PMID:38585195
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2., PMID:38581859
Construction and validation of a hypoxia-related gene signature to predict the prognosis of breast cancer., PMID:38561760
Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitis., PMID:38433843
A novel cholesterol metabolism-related ferroptosis pathway in hepatocellular carcinoma., PMID:38191842
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution., PMID:37603745
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities., PMID:37373195
[Integrated strategy for biomarkers of stable coronary heart disease with phlegm and blood stasis syndrome based on RNA-seq and network pharmacology]., PMID:37282967
Novel diagnostic biomarkers of T cell-mediated tumor killing characteristics for early-stage triple negative breast cancer: A SEER analysis and molecular portraits., PMID:36827041
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells., PMID:36801644
Effect of atorvastatin on lipoxygenase pathway-related gene expression in an in vitro model of lipid accumulation in hepatocytes., PMID:36637998
ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons., PMID:36581060
One Step Nucleic Acid Amplification (OSNA) Lysate Samples Are Suitable to Establish a Transcriptional Metastatic Signature in Patients with Early Stage Hormone Receptors-Positive Breast Cancer., PMID:36497336
Ferroptosis-related biomarkers for Alzheimer's disease: Identification by bioinformatic analysis in hippocampus., PMID:36467613
Runs of Homozygosity Revealed Reproductive Traits of Hu Sheep., PMID:36292733
Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas., PMID:36159811
Correlation between novel compound heterozygous ADAMTSL4 variants and primary phenotypes of ectopia lentis et pupillae., PMID:36089008
Growth State-Dependent Expression of Arachidonate Lipoxygenases in the Human Endothelial Cell Line EA.hy926., PMID:36010555
Structural and functional evaluation mammalian and plant lipoxygenases upon association with nanodics as membrane mimetics., PMID:35849958
Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line., PMID:35568821
The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells., PMID:35344833
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?, PMID:35308198
Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms., PMID:34801853
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2., PMID:34500187
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2., PMID:34029049
Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva., PMID:33915294
Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15., PMID:33807076
Oxygenation of endocannabinoids by mammalian lipoxygenase isoforms., PMID:33662546
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma., PMID:33114768
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1., PMID:33048542
Human lipoxygenase isoforms form complex patterns of double and triple oxygenated compounds from eicosapentaenoic acid., PMID:32841762
Expression profile of lipoxygenases in gingival tissues of human periodontitis., PMID:32677134
Molecular signature of slowly expanding lesions in progressive multiple sclerosis., PMID:32577755
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages., PMID:32222425
Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism., PMID:32107839
Exploring and characterizing a novel combination of paeoniflorin and talatizidine for the treatment of rheumatoid arthritis., PMID:32001347
Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis., PMID:31420013
Cardioprotection of (±)-sodium 5-bromo-2-(α-hydroxypentyl) benzoate (BZP) on mouse myocardium I/R injury through inhibiting 12/15-LOX-2 activity., PMID:31362020
Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas., PMID:31288808
Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis., PMID:30667533
Targeted Lignan Profiling and Anti-Inflammatory Properties of Schisandra rubriflora and Schisandra chinensis Extracts., PMID:30486445
For research use only. Not for human or drug use.
