KLK6 Promotes Growth, Migration, and Invasion of Gastric Cancer Cells. PMID: 30607299
Ectopic expression of KLK6 in MDA-MB-435 melanoma cells reduces tumorigenicity in vivo. PMID: 33249398
KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages. PMID: 36552865
KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma. PMID: 36193495
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion. PMID: 36413626
KLK6 protease accelerates skin tumor formation and progression. PMID: 30137206
KLK6 mediates stemness and metabolism of gastric carcinoma cells via the PI3K/AKT/mTOR signaling pathway. PMID: 34691251
KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes. PMID: 27093921
KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species. PMID: 27845893
Biochemical pathways mediated by KLK6 protease in breast cancer. PMID: 30980596
A proinflammatory role of KLK6 protease in Netherton syndrome. PMID: 31255470
Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis. PMID: 35883559
A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis. PMID: 34858488
A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma. PMID: 32158625
[Expression of KLK6 protein and mRNA in primary breast cancer and its clinical significance]. PMID: 18992199
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease. PMID: 32155135
Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma. PMID: 25153391
Study of kallikrein-related peptidase 6 (KLK6) and its complex with α1-antitrypsin in biological fluids. PMID: 28672746
KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. PMID: 19707197
Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes. PMID: 25477184
Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates. PMID: 18243805
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein. PMID: 31692974
Blocking Kallikrein 6 promotes developmental myelination. PMID: 34626143
Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients. PMID: 29435805
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease. PMID: 29378650
Kallikrein-related peptidase 6 (KLK6)gene expression in intracranial tumors. PMID: 22477710
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer. PMID: 22373580
The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6). PMID: 22047144
Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease? PMID: 28254587
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer. PMID: 27483364
Proteinase KLK6 links skin and joint inflammation in PsA. PMID: 32231304
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. PMID: 29934309
Kallikrein-related peptidase-6 (KLK6) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma. PMID: 24430362
Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6. PMID: 23216878
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer. PMID: 34065672
Multiplex Protein Biomarker Profiling in Patients with Familial Hypercholesterolemia. PMID: 34680994
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects. PMID: 17242704
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. PMID: 22505521
Kallikrein-related peptidases in lung diseases. PMID: 29604204
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins. PMID: 23376368
COMP (Cartilage Oligomeric Matrix Protein) Neoepitope: A Novel Biomarker to Identify Symptomatic Carotid Stenosis. PMID: 33472398
Prostate cancer: In a SNP: KLK6 mutations in aggressive disease. PMID: 28374791
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer. PMID: 22285222
Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. PMID: 21656738
Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis. PMID: 29086442
Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains. PMID: 25666037
Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia. PMID: 20846516
Proteomics and functional study reveal kallikrein-6 enhances communicating hydrocephalus. PMID: 34915845
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. PMID: 22505518
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma. PMID: 34439122
One round of SELEX for the generation of DNA aptamers directed against KLK6. PMID: 22505517
Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells. PMID: 18283336
Copy number and expression alterations of miRNAs in the ovarian cancer cell line OVCAR-3: impact on kallikrein 6 protein expression. PMID: 23136250
Development of monoclonal antibodies to human kallikrein-related peptidase 6 (KLK6) and their use in an immunofluorometric assay for free KLK6. PMID: 25153392
Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy. PMID: 23832758
Structure of plasma and tissue kallikreins. PMID: 23494059
CEACAM5, KLK6, SLC35D3, POSTN, and MUC2 mRNA Analysis Improves Detection and Allows Characterization of Tumor Cells in Lymph Nodes of Patients Who Have Colon Cancer. PMID: 34192710
Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma. PMID: 18854834
Physiological and pathological roles of kallikrein-related peptidases in the epidermis. PMID: 31279501
Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer. PMID: 30114962
Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain. PMID: 32974895
Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma. PMID: 23307575
Kallikrein-related peptidase 6: a biomarker for traumatic brain injury in the rat. PMID: 24266798
Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids. PMID: 27283773
Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion. PMID: 17804733
Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance. PMID: 22964375
Functional role of kallikrein 6 in regulating immune cell survival. PMID: 21464892
Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids. PMID: 18627291
Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6. PMID: 28431272
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. PMID: 18627290
Functional interrelationships between the kallikrein-related peptidases family and the classical kinin system in the human neutrophil. PMID: 29883315
Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck. PMID: 27844409
Differential protein profiling as a potential multi-marker approach for obese patients with heart failure: A retrospective study. PMID: 29784904
Prognostic value of kallikrein-related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA). PMID: 18957059
Prognostic significance of multiple kallikreins in high-grade astrocytoma. PMID: 26231762
Differential expression of cancer-associated proteins in breastmilk. PMID: 23373436
Kallikrein-related peptidases: proteolysis and signaling in cancer, the new frontier. PMID: 20180639
Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness. PMID: 21741862
Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis. PMID: 22335454
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients. PMID: 25990935
Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer. PMID: 27863404
Application of machine learning to large in vitro databases to identify drug-cancer cell interactions: azithromycin and KLK6 mutation status. PMID: 33953352
Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer. PMID: 16203767
Development of Monoclonal Antibodies and Characterization of an ELISA Platform Against Kallikrein-Related Peptidase 6 as a Tumor Biomarker. PMID: 26492623
Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma. PMID: 29224812
The autolytic regulation of human kallikrein-related peptidase 6. PMID: 17417874
Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer. PMID: 15837738
Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. PMID: 23647384
The utility of breastmilk for genetic or genomic studies: a systematic review. PMID: 23259645
In-silico analysis of kallikrein gene expression in pancreatic and colon cancers. PMID: 15015574
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. PMID: 19383923
Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. PMID: 21753781
Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6. PMID: 31675166
Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6. PMID: 30015976
Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease. PMID: 12480753
High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. PMID: 19426157
Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis. PMID: 27533119
Role of kallikrein enzymes in the central nervous system. PMID: 12589961
Recombinant kallikrein expression: site-specific integration for hK6 production in human cells. PMID: 16800729
Pathophysiological Implications of Urinary Peptides in Hepatocellular Carcinoma. PMID: 34359689
Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans. PMID: 25351201
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. PMID: 16800739
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7. PMID: 18627343
Novel immunotherapeutic strategies in gynecologic oncology. Dendritic cell-based immunotherapy for ovarian cancer. PMID: 12032451
[Kallikrein-family serine protease in the central nervous system]. PMID: 14531278
Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET. PMID: 31467673
Separation of kallikrein 6 glycoprotein subpopulations in biological fluids by anion-exchange chromatography coupled to ELISA and identification by mass spectrometry. PMID: 22539431
Exercise improves the body function and protects the neuronal injury in Parkinson's disease rats by activating calpain 1 and kallikrein 6. PMID: 36382482
Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms. PMID: 29604205
Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI. PMID: 28726131
Substrate specificity of human kallikreins 1 and 6 determined by phage display. PMID: 18359858
For research use only. Not for human or drug use.
