Catalog No.
YHK91901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met156-Asp275
Predicted molecular weight
16.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5T7V8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NTKLBP1, NTKL-BP1, SCYL1-binding protein 1, SCYL1BP1, SCY1-like 1-binding protein 1, GORAB, NTKL-binding protein 1, SCYL1-BP1, hNTKL-BP1, RAB6-interacting golgin, N-terminal kinase-like-binding protein 1
The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication. PMID: 33704067
Gorab is a Golgi protein required for structure and duplication of Drosophila centrioles. PMID: 29892014
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation. PMID: 30631079
Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis. PMID: 26967474
GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting. PMID: 26000619
Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab. PMID: 36331102
GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration. PMID: 32067289
The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation. PMID: 33321764
Examining tissue composition, whole-bone morphology and mechanical behavior of GorabPrx1 mice tibiae: A mouse model of premature aging. PMID: 29108851
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PMID: 29561836
Recent advances on biomedical applications of pectin-containing biomaterials. PMID: 35809676
Cex1 is a component of the COPI intracellular trafficking machinery. PMID: 33753324
A Case of Geroderma Osteodysplasticum Syndrome: Unique Clinical Findings. PMID: 35707774
Osteogenesis imperfecta in 140 Turkish families: Molecular spectrum and, comparison of long-term clinical outcome of those with COL1A1/A2 and biallelic variants. PMID: 34902613
Variants of SARS-CoV-2: Influences on the Vaccines' Effectiveness and Possible Strategies to Overcome Their Consequences. PMID: 36984508
Novel compound heterozygous mutations identified by whole exome sequencing in a Japanese patient with geroderma osteodysplastica. PMID: 28807865
The phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than autosomal recessive cutis laxa type 2. PMID: 21204221
Cloning and characterization of a novel gene which encodes a protein interacting with the mitosis-associated kinase-like protein NTKL. PMID: 12783284
Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. PMID: 27539004
Further characterization of ATP6V0A2-related autosomal recessive cutis laxa. PMID: 22773132
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency. PMID: 28409271
Interaction interface in the C-terminal parts of centriole proteins Sas6 and Ana2. PMID: 33171067
Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination. PMID: 20849854
Dramatic nucleolar dispersion in the salivary gland of Schwenkfeldina sp. (Diptera: Sciaridae). PMID: 33863925
[Gene expression analysis and its clinical use in breast tumors]. PMID: 23805447
Functionalization of chitosan by metformin, nickel metal ions and magnetic nanoparticles as a nanobiocomposite for purification of alkaline phosphatase from hen's egg yolk. PMID: 35933767
Unusual chromatin state in Rhynchosciara americana (Diptera: Sciaridae). PMID: 26490538
A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles. PMID: 35610263
The DNA puff 4C expresses a salivary secretion protein in Trichosia pubescens (Diptera; Sciaridae). PMID: 18076109
SCYL1BP1 has tumor-suppressive functions in human lung squamous carcinoma cells by regulating degradation of MDM2. PMID: 25227860
Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin. PMID: 18997784
Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA. PMID: 23353788
SCYL1-BP1 affects cell cycle arrest in human hepatocellular carcinoma cells via Cyclin F and RRM2. PMID: 25980818
Transcriptional profiling and dynamical regulation analysis identify potential kernel target genes of SCYL1-BP1 in HEK293T cells. PMID: 25234469
Thiazole Orange as an Alternative to Antibody Binding for Detecting Triple-helical DNA in Heterochromatin of Drosophila and Rhynchosciara. PMID: 29268630
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures. PMID: 26205790
Clinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa. PMID: 23963297
Immunoelectron microscopy of RNA combined with nucleic acid cytochemistry in plant nucleoli. PMID: 7514537
Antibodies against the D-domain of a Chironomus ecdysone receptor protein react with DNA puff sites in Trichosia pubescens. PMID: 9391218
Specific intranucleolar distribution of Hsp70 during heat shock in polytene cells. PMID: 9367619
Reverse transcriptase-related proteins in telomeres and in certain chromosomal loci of Rhynchosciara (Diptera: Sciaridae). PMID: 12707782
Human articular cartilage storage in cell culture medium: guidelines for storage of fresh osteochondral allografts. PMID: 9195632
Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. PMID: 25819896
A novel missense mutation in SCYL1BP1 produces geroderma osteodysplastica phenotype indistinguishable from that caused by nullimorphic mutations. PMID: 19681135
Chromatin structure of ribosomal RNA genes in dipterans and its relationship to the location of nucleolar organizers. PMID: 22952852
Potential sites of triple-helical nucleic acid formation in chromosomes of Rhynchosciara (Diptera: Sciaridae) and Drosophila melanogaster. PMID: 19763852
The gene Sex-lethal of the Sciaridae family (order Diptera, suborder Nematocera) and its phylogeny in dipteran insects. PMID: 15514063
Coproantibodies in intestinal amebiasis. PMID: 227337
Chromatin structure of ribosomal genes in Chironomus thummi (Diptera: Chironomidae): tissue specificity and behaviour under drug treatment. PMID: 17487564
The effects of temperature shock on transcription and replication in Rhynchosciara americana (Diptera: Sciaridae). PMID: 16636922
Local enrichment with homopolymeric (dA/dT) DNA in genomes of some lower dipterans and Drosophila melanogaster. PMID: 12707783
Curiously composite structures of a retrotransposon and a complex repeat associated with chromosome ends of Rhynchosciara americana (Diptera: Sciaridae). PMID: 20607598
A new approach to map transcription sites at the ultrastructural level. PMID: 7505298
Ku-related antigens are associated with transcriptionally active loci in Chironomus polytene chromosomes. PMID: 8781183
For research use only. Not for human or drug use.
