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Recombinant Human FOSL2 Protein, N-GST & C-His

Catalog #:   YHD11001 Specific References (104) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: P15408
Protein length: Arg127-His187
Overview

Catalog No.

YHD11001

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Arg127-His187

Predicted molecular weight

35.57 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P15408

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

FOSL2, Fos-related antigen 2, FRA-2, FRA2

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human FOSL2 protein
References

FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts. PMID: 33754039

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer. PMID: 32548260

Fra-2-expressing macrophages promote lung fibrosis in mice. PMID: 31135379

Nucleolar localization of c-Jun. PMID: 34499807

The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes. PMID: 28050569

SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop. PMID: 34782005

FOSL2 positively regulates TGF-β1 signalling in non-small cell lung cancer. PMID: 25375657

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin. PMID: 34282151

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development. PMID: 32610127

Identification and functional analysis of a three-miRNA ceRNA network in hypertrophic scars. PMID: 34715879

Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration. PMID: 34475534

FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects. PMID: 36197437

Fos-like antigen 2 (FOSL2) promotes metastasis in colon cancer. PMID: 30114390

Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. PMID: 35034245

Inhibition of FOSL2 aggravates the apoptosis of ovarian cancer cells by promoting the formation of inflammasomes. PMID: 34773569

FOSL2 deficiency delays nonalcoholic steatohepatitis progression by regulating LY6D-mediated NLRP3 activation. PMID: 35930135

Circ_0091581 Promotes the Progression of Hepatocellular Carcinoma Through Targeting miR-591/FOSL2 Axis. PMID: 33040214

Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells. PMID: 34604665

Gene expression in the epileptic (EL) mouse hippocampus. PMID: 33153970

Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury. PMID: 34754625

Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis. PMID: 30081074

A validated regulatory network for Th17 cell specification. PMID: 23021777

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. PMID: 33238123

Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway. PMID: 36920708

FOSL2 promotes leptin gene expression in human and mouse adipocytes. PMID: 22326952

Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. PMID: 21367864

microRNA-143-3p contributes to inflammatory reactions by targeting FOSL2 in PBMCs from patients with autoimmune diabetes mellitus. PMID: 32815005

FOSL2 promotes intertumoral infiltration of T cells and increases pathological complete response rates in locally advanced rectal cancer patients. PMID: 36997107

Hsa_circ_0001869 promotes NSCLC progression via sponging miR-638 and enhancing FOSL2 expression. PMID: 33221767

KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease. PMID: 34271875

Calcitonin gene‑related peptide regulates FOSL2 expression and cell proliferation of BMSCs via mmu_circRNA_003795. PMID: 30896827

The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. PMID: 26732840

Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition. PMID: 36018564

A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation. PMID: 35511484

The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P-1 Sertoli cells. PMID: 36468795

Mechanism of TCONS_00147848 regulating apoptosis of nasal mucosa cells and alleviating allergic rhinitis through FOSL2-mediated JAK/STAT3 signaling pathway. PMID: 34362948

MicroRNA-30e promotes hepatocyte proliferation and inhibits apoptosis in cecal ligation and puncture-induced sepsis through the JAK/STAT signaling pathway by binding to FOSL2. PMID: 29787988

Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis. PMID: 32440152

Role of linc00174/miR-138-5p (miR-150-5p)/FOSL2 Feedback Loop on Regulating the Blood-Tumor Barrier Permeability. PMID: 31791014

miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2. PMID: 28393251

miR-143-3p inhibits the proliferation, migration and invasion in osteosarcoma by targeting FOSL2. PMID: 29330462

The CpG Island-Binding Protein SAMD1 Contributes to an Unfavorable Gene Signature in HepG2 Hepatocellular Carcinoma Cells. PMID: 35453756

LncRNA LINC00313 Knockdown Inhibits Tumorigenesis and Metastasis in Human Osteosarcoma by Upregulating FOSL2 through Sponging miR-342-3p. PMID: 32390359

LncRNA GSTM3TV2 Promotes Cell Proliferation and Invasion via miR-597/FOSL2 Axis in Hepatocellular Carcinoma. PMID: 34458365

Recent advances in animal models of systemic sclerosis. PMID: 26782003

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli. PMID: 31932373

The Fra-2 transgenic mouse model of systemic sclerosis. PMID: 23232070

MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. PMID: 30086463

Animal models of scleroderma: current state and recent development. PMID: 24150871

Degradation of c-Fos protein expressed by N-methyl-D-aspartic acid in nuclear fractions of murine hippocampus. PMID: 11423077

EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2. PMID: 33712565

Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. PMID: 36077499

Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome. PMID: 37179374

Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors. PMID: 37173651

Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis. PMID: 32048611

Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. PMID: 37042252

Developmental expression patterns of fosl genes in Xenopus tropicalis. PMID: 31121318

Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas. PMID: 35641855

Unifying mechanism for different fibrotic diseases. PMID: 28424250

Social Fear Affects Limbic System Neuronal Activity and Gene Expression. PMID: 35897794

Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases. PMID: 31473307

Verteporfin-loaded microparticles for radiosensitization of preclinical lung and breast metastatic spine cancer. PMID: 36585863

Transcription factor AP-1, and the role of Fra-2. PMID: 8723999

Anti-neuroinflammatory effects of Eucommia ulmoides Oliv. In a Parkinson's mouse model through the regulation of p38/JNK-Fosl2 gene expression. PMID: 32464317

Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA‑597‑3p/FOSL2 pathway. PMID: 33000177

A Systematic Review of Transcriptional Dysregulation in Huntington's Disease Studied by RNA Sequencing. PMID: 34721539

OX40L blockade protects against inflammation-driven fibrosis. PMID: 27298374

Activator protein-1 complex expressed by magnetism in cultured rat hippocampal neurons. PMID: 11890693

Progesterone receptor transcriptome and cistrome in decidualized human endometrial stromal cells. PMID: 25781565

SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis. PMID: 36932385

Molecular mechanisms of pathogenesis in hepatocellular carcinoma revealed by RNA‑sequencing. PMID: 28901494

Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts. PMID: 15299028

Alternatively activated macrophages promote airway inflammation through JAK3-STAT5-Fra2 in asthma. PMID: 35670841

Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. PMID: 20585340

Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b. PMID: 33188281

The gene encoding the Fos-related antigen 2 (Fosl2) maps to mouse chromosome 5. PMID: 9069127

Progesterone Inhibits the Establishment of Activation-Associated Chromatin During TH1 Differentiation. PMID: 35185927

Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts. PMID: 15128746

Fra-2 Is a Dominant Negative Regulator of Natural Killer Cell Development. PMID: 35812461

Jun and Fos family protein expression in human breast cancer: correlation of protein expression and clinicopathological parameters. PMID: 17009623

Screening and verification of hub genes involved in osteoarthritis using bioinformatics. PMID: 33732303

New insights into adipocyte-specific leptin gene expression. PMID: 23700528

Fos family members: regulation, structure and role in oncogenic transformation. PMID: 10963134

Global transcriptome analysis to identify critical genes involved in the pathology of osteoarthritis. PMID: 29922448

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma. PMID: 30903020

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. PMID: 32149459

The role of microRNA-5196 in the pathogenesis of systemic sclerosis. PMID: 28639412

MiR-124-3p suppresses glioma aggressiveness via targeting of Fra-2. PMID: 30243808

Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. PMID: 20837772

Prostaglandin F2α regulation of mRNA for activating protein 1 transcriptional factors in porcine corpora lutea (CL): lack of induction of JUN and JUND in CL without luteolytic capacity. PMID: 23089279

Transcription Factors Leading to High Expression of Neuropeptide L1CAM in Brain Metastases from Lung Adenocarcinoma and Clinical Prognostic Analysis. PMID: 35003395

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. PMID: 27471255

Identifying hub circadian rhythm biomarkers and immune cell infiltration in rheumatoid arthritis. PMID: 36238290

Cardiomyopathy in murine models of systemic sclerosis. PMID: 25371068

Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation. PMID: 33385611

GOLPH3 modulates expression and alternative splicing of transcription factors associated with endometrial decidualization in human endometrial stromal cells. PMID: 36967990

Endothelin-1 regulates rat bone sialoprotein gene transcription. PMID: 20587945

MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability. PMID: 15558021

Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T-lymphocytes: A bioinformatic analysis. PMID: 36092920

Mitogen-activated protein kinases and activator protein 1 are required for proliferation and cardiomyocyte differentiation of P19 embryonal carcinoma cells. PMID: 11884386

Mitogen activated protein kinase-dependent activation of c-Jun and c-Fos is required for neuronal differentiation but not for growth and stress response in PC12 cells. PMID: 17111371

Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst. PMID: 32011035

Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis. PMID: 30990796

Identification of Immediate Early Genes in the Nervous System of Snail Helix lucorum. PMID: 31053606

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human FOSL2 Protein, N-GST & C-His [YHD11001]
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