Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism. PMID: 33042519
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. PMID: 34499618
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. PMID: 27797339
Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension. PMID: 33836561
MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites. PMID: 35182051
NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice. PMID: 15644457
How widespread is stable protein S-nitrosylation as an end-effector of protein regulation? PMID: 28189849
Virtual screening of active compounds from Artemisia argyi and potential targets against gastric ulcer based on Network pharmacology. PMID: 31005783
The deleterious impact of a non-synonymous SNP on protein structure and function is apparent in hypertension. PMID: 34961886
Resolution for sepsis? PMID: 15630034
Caveolae and signaling. PMID: 11353331
In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2. PMID: 35585170
Homocysteine reduces protein S-nitrosylation in endothelium. PMID: 25189662
Effects of polymorphisms of NOS3 and GNB3 genes on skin microvascular reactivity in normal pregnancy. PMID: 23667878
Activation of the STAT1 Pathway Accelerates Periodontitis in Nos3-/- Mice. PMID: 31329047
AMP-activated protein kinase is a key regulator of acute neurovascular permeability. PMID: 33712448
Involvement of NOS3 in RA-Induced neural differentiation of human NT2/D1 cells. PMID: 22987726
[Progress in genetic research on essential tremor]. PMID: 28981951
Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent. PMID: 20953358
17beta-Estradiol induces protein S-nitrosylation in the endothelium. PMID: 19914929
How does Viagra protect the ischemic heart? PMID: 19346460
Mechanisms of NO neurotoxicity. PMID: 9932445
Expression and distribution of NOS1 and NOS3 in the myocardium of angiotensin II-infused rats. PMID: 11408389
Focus on: "G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor". PMID: 9843698
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. PMID: 24319055
SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3). PMID: 36720357
Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer. PMID: 36288877
Global protein expression profiling underlines reciprocal regulation of caveolin 1 and endothelial nitric oxide synthase expression in ovariectomized sheep uterine artery by estrogen/progesterone replacement therapy. PMID: 16436525
It's a knockout! PMID: 9613207
Cellular signaling and NO production. PMID: 20082095
Blood pressure control goes nuclear. PMID: 15514165
Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat. PMID: 33971615
Inflammation, oxidative stress, and atherosclerosis. PMID: 15017368
Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity. PMID: 21421555
Targeting Rho in cardiovascular disease. PMID: 11009552
Nitrosative stress and transcription. PMID: 14669980
S100A1: A novel and essential molecular component for postischemic angiogenesis. PMID: 23287450
Beta-actin: a regulator of NOS-3. PMID: 17878410
Transcriptional regulation of endothelial nitric oxide synthase expression in uterine artery endothelial cells by c-Jun/AP-1. PMID: 17933457
Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. PMID: 19345227
Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension. PMID: 35489051
Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II. PMID: 11880293
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease. PMID: 29973202
Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. PMID: 15069547
Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway. PMID: 31618402
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. PMID: 29891729
Double tribble: two TRIB3 variants, insulin, Akt, and eNOS. PMID: 18565845
Signal transduction of eNOS activation. PMID: 10690325
Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. PMID: 25694588
Expression of a NOS-III-like protein in human astroglial cell culture. PMID: 9837744
Thioredoxin-related regulation of NO/NOS activities. PMID: 12076971
Endothelial nitric oxide synthase in the amphibian, Xenopus tropicalis. PMID: 21199680
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. PMID: 15576651
[Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes]. PMID: 33849420
Nontranscriptional actions of the glucocorticoid receptor. PMID: 12682725
The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle. PMID: 29401588
Caveolae and caveolins in the cardiovascular system. PMID: 15192036
Molecular mechanisms underlying the activation of eNOS. PMID: 20012875
eNOS inhibition of proliferation: a role for p21(Sdi1/Cip1/Waf1) and p27(kip1). PMID: 10974212
Gene-Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril. PMID: 27696692
Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction. PMID: 28727928
Genetic determinants of coronary vasomotor tone in humans. PMID: 11557533
Pharmacogenomics for the treatment of dementia. PMID: 12452480
Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis. PMID: 23393387
Contributions of Nitric Oxide to AHR-Ligand-Mediated Keratinocyte Differentiation. PMID: 32784365
Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches. PMID: 31244373
Proliferation of regulatory mechanisms for eNOS: an emerging role for the cytoskeleton. PMID: 12003771
Regulatory mechanisms of hepatic microcirculation. PMID: 14724338
Nitroglycerin tolerance in caveolin-1 deficient mice. PMID: 25158065
G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis. PMID: 22294688
Activated protein C induction of MCP-1 in human endothelial cells: a possible role for endothelial cell nitric oxide synthase. PMID: 11672583
Identification of gene variants in NOS3, ET-1 and RAS that confer risk and protection against microangiopathy in type 2 diabetic obese subjects. PMID: 21406182
Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells. PMID: 19692121
Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases. PMID: 11919080
Purification of caveolae-derived membrane microdomains containing lipid-anchored signaling molecules, such as GPI-anchored proteins, H-Ras, Src-family tyrosine kinases, eNOS, and G-protein alpha-, beta-, and gamma-subunits. PMID: 10399145
MCP-induced protein 1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells. PMID: 20561987
Exercise and cardiovascular health: get active to "AKTivate" your endothelial nitric oxide synthase. PMID: 12835404
Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling. PMID: 32580946
Sepsis is associated with reciprocal expressional modifications of constitutive nitric oxide synthase (NOS) in human skeletal muscle: down-regulation of NOS1 and up-regulation of NOS3. PMID: 11546971
Nine genetic polymorphisms associated with power athlete status - A Meta-Analysis. PMID: 28666769
Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice. PMID: 28189851
alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. PMID: 19920353
Changes in histological structure and nitric oxide synthase expression in aorta of rats supplemented with bee pollen or whey protein. PMID: 30835492
Nitric oxide and Bartter and Gitelman syndromes. PMID: 11532116
Anthracycline-induced cardiotoxicity in women without cardiovascular diseases: molecular and genetic predictors. PMID: 34783301
Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean? PMID: 11090536
Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. PMID: 23472125
Modern angiogenic thermal therapy from the country of traditional thermal therapy. PMID: 22664487
Nitric oxide synthase-3 promotes embryonic development of atrioventricular valves. PMID: 24204893
Do we kNOw how HSP90 and eNOS mediate lung injury in sickle cell disease? PMID: 15003934
Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR, MAP2K2, and NOS3) gene expressions in metabolic syndrome. PMID: 26956845
Selective dysregulation of nitric oxide synthase type 3 in cardiac myocytes but not coronary microvascular endothelial cells of spontaneously hypertensive rat. PMID: 9747440
Characterization of the sex-dependent myocardial S-nitrosothiol proteome. PMID: 26702143
Angiogenesis related genes NOS3, CD14, MMP3 and IL4R are associated to VEGF gene expression and circulating levels in healthy adults. PMID: 26437765
Role of Akt signaling in vascular homeostasis and angiogenesis. PMID: 12089061
Akt signaling and its role in postnatal neovascularization. PMID: 15578445
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. PMID: 20974940
Lipopolysaccharide down-regulates Sp1 binding activity by promoting Sp1 protein dephosphorylation and degradation. PMID: 12089157
Tumor necrosis factor alpha regulates nitric oxide synthase expression in portal hypertensive gastric mucosa of rats. PMID: 9537427
Endothelial nitric oxide synthase expression and its functionality. PMID: 10453308
Emerging mechanisms for secondary cardioprotective effects of statins. PMID: 11557228
Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia. PMID: 30627907
Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs. PMID: 19570880
Nitric oxide synthase 1 and nitric oxide synthase 3 protein expression is regionally and temporally regulated in fetal brain. PMID: 8873971
Evaluation of placental protein modifications in normotensive and spontaneously hypertensive rats. PMID: 18358529
All in the family: VEGF-B joins the ranks of proangiogenic cytokines. PMID: 12881472
[Integrating single-cell analysis and epharmalib reverse virtual screening to predict novel vascular endothelial cell targets of dapagliflozin in treating diabetic cardiomyopathy]., PMID:40528600
Identification and Validation of Oxidative Stress-Related Diagnostic Marker Genes and Immune Landscape in Ulcerative Interstitial Cystitis by Integrating Bioinformatics and Machine Learning., PMID:40497148
HTLV-1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice., PMID:40495291
Lupus nephritis serum induces changes in gene expression in human glomerular endothelial cells, which is modulated by L-sepiapterin: implications for redox-mediated endothelial dysfunction., PMID:40480647
Increased CSF drainage by non-invasive manipulation of cervical lymphatics., PMID:40468071
miR-486-5p Inhibits eNOS and Angiogenesis in Cultured Endothelial Cells by Targeting MAML3., PMID:40432288
Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies., PMID:40425728
ICAM1 778G>A (rs1799969), ADD1 1378G>T (rs4961), NPPA 553T>C (rs5065), and NOS3 894G>T (rs1799983) Variants in Infants with Gastroschisis from Western Mexico., PMID:40421935
Integrating LC-MS and molecular docking technology to investigate the effect of Spatholobi caulis flavonoids in alleviating primary dysmenorrhea via regulating the RhoA/ROCK pathway., PMID:40414437
Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms., PMID:40389042
Study on the mechanism of acteoside in treating purinomycin aminonucleoside-induced chronic glomerulonephritis in childhood rats based on Cxcr4-PI3K-Akt-eNOS axis., PMID:40389008
Molecular characterization of NOS3 and SOD1 genes as markers for detecting patients with breast cancer., PMID:40388013
DNA Methylation of iNOS, eNOS, TP53 and LINE-1 in Gingival Tissues of Cigarette Smokers, Heat-Not-Burn Smokers and Never Smokers: An Exploratory Study., PMID:40387376
Combined effects and potential mechanisms of volatile organic compounds on thyroid disease in the US population: An integrated epidemiological and computational toxicology study., PMID:40378728
Adropin contributes to the nephro-protective effect of vitamin D in renal aging in a rat model via MAPK/HIFα/VEGF/eNOS mechanism., PMID:40348136
Rehmanniae Radix Praeparata in Blood Deficiency Syndrome: UPLC-Q-TOF-MS Profiling, Network Pharmacology, and PI3K-AKT Activation., PMID:40332770
Unique and overlapping mechanisms of valbenazine, deutetrabenazine, and vitamin E for tardive dyskinesia., PMID:40268947
Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression., PMID:40259553
Characterization of two novel angiotensin converting enzyme-inhibitory peptides from yellow tuna peptides: Inhibitory mechanism, transport route and network pharmacology analysis., PMID:40253180
Intermedin protects peritubular capillaries by inhibiting eNOS uncoupling through AMPK/GTPCH-I/BH4 pathway and alleviate CKD following AKI., PMID:40228707
Modulation of VEGF/eNOS/TGF-β Axis by Piracetam as a New Avenue to Ameliorate Valproic Acid-Induced Placental Toxicity and Teratogenicity in Rats., PMID:40226982
Analysis of Gene Polymorphisms in Benign Prostate Hyperplasia Patients Receiving Combination Therapy of Alpha Blocker (a-Blocker) and 5-Alpha Reductase Inhibitor (5-ARI)., PMID:40223852
Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity., PMID:40204283
Role of adenosine A3 receptor and endothelial nitric oxide synthase in patients with traumatic hemorrhagic shock., PMID:40198384
Alleviation of accelerated diabetic atherogenesis in STZ-treated apoE/NOX1 DKO mice, apoE-/-/tg-EC-DHFR mice, and by folic acid., PMID:40184644
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway., PMID:40170728
Ursolic Acid Ameliorates Vascular Oxidative Stress and Upregulates Endothelial Nitric Oxide Synthase Gene in Male Wistar Rats with High-carbohydrate High-fat Diet-induced Metabolic Syndrome., PMID:40156788
Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study., PMID:40149590
FTO and NOS3 genes associated with pediatric obesity: Corações de Ouro Preto study., PMID:40114142
A Light-Activatable Nitric Oxide Donor for Targeted Glaucoma Therapy with Real-Time Monitoring Capabilities., PMID:40103449
RasGRP2 Attenuates TAGE Modification of eNOS in Vascular Endothelial Cells., PMID:40101981
Genetic Associations with the Susceptibility to High-Altitude Pulmonary Edema in the Japanese Population., PMID:40094446
Radiofrequency electromagnetic field ınhibits HIF-1 alpha and activates eNOS signaling to prevent intestinal damage in a model of mesenteric artery ischemia in rats., PMID:40084245
Adipokine levels and T786C polymorphism of eNOS gene promoter correlation in patients with arterial hypertension., PMID:40073405
Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice., PMID:40062975
L-Citrulline Alleviates Testicular Ischemia/Reperfusion Injury in Rats by Modulating eNOS/iNOS Induced Nitric Oxide Production, Inflammation, and Apoptosis., PMID:40059720
Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer's disease., PMID:40055645
Upregulation of COX-2 and NADPH Oxidase and Reduced eNOS in Perivascular Adipose Tissue Are Associated With Resistance Artery Dysfunction and Hypertension in Naturally Aged Mice., PMID:40037608
Air pollution and prostate cancer: Unraveling the connection through network toxicology and machine learning., PMID:40022828
Effects of 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid on Regulating Oxidative Stress and Muscle Fiber Composition., PMID:40004996
Unveiling the Negative Synergistic Effect of Wall Shear Stress and Insulin on Endothelial NO Dynamics by Mathematical Modeling., PMID:39969626
Eucalyptol attenuates indomethacin-induced gastric ulcers in rats by modulating the ICAM-1, eNOS and COX/LOX pathways: Insights from in silico, in vitro and in vivo approaches., PMID:39965739
Acetylcholine-loaded nanoparticles protect against doxorubicin-induced toxicity inin vitrocardiac spheroids., PMID:39965540
The association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and diabetic retinopathy among patients with type 2 diabetes: A case-control study., PMID:39959179
GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia., PMID:39958322
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway., PMID:39957706
Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis., PMID:39954797
Genetic association of MIR-449B, GCLC, eNOS, SORD, and ENPP1 with diabetic retinopathy., PMID:39952424
Tadalafil Ameliorates Chronic Ischemia-Associated Bladder Overactivity in Fructose-Fed Rats by Exerting Pelvic Angiogenesis and Enhancing p-eNOS Expression., PMID:39941129
Endothelial cell-specific postnatal deletion of Nos3 preserves intraocular pressure homeostasis via macrophage recruitment and NOS2 upregulation., PMID:39932792
For research use only. Not for human or drug use.
