Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management. PMID: 34589395
Alzheimer's disease risk genes and mechanisms of disease pathogenesis. PMID: 24951455
The role of CD2AP in the Pathogenesis of Alzheimer's Disease. PMID: 31440393
The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. PMID: 27076424
Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. PMID: 27765817
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems. PMID: 34708251
Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. PMID: 20404345
CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway. PMID: 31138646
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. PMID: 11856766
FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions. PMID: 24322428
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease. PMID: 34514662
CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP. PMID: 16895919
CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia. PMID: 23090967
The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R. PMID: 25261582
Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. PMID: 23279575
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. PMID: 34949639
CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency. PMID: 15951437
CD2AP inhibits metastasis in gastric cancer by promoting cellular adhesion and cytoskeleton assembly. PMID: 31989722
The role of Alzheimer's disease risk genes in endolysosomal pathways. PMID: 34871734
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. PMID: 12672817
Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). PMID: 26296892
Capping protein regulators fine-tune actin assembly dynamics. PMID: 25207437
Adaptor protein CD2AP and L-type lectin LMAN2 regulate exosome cargo protein trafficking through the Golgi complex. PMID: 28986432
New insight into podocyte slit diaphragm, a therapeutic target of proteinuria. PMID: 32020343
Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex. PMID: 31235616
Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein. PMID: 31493651
Transcriptional activation of the human CD2AP promoter by E2F1. PMID: 22880102
Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3. PMID: 21604172
The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling. PMID: 36754282
CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains. PMID: 24425877
Identification and characterisation of a Theileria annulata proline-rich microtubule and SH3 domain-interacting protein (TaMISHIP) that forms a complex with CLASP1, EB1, and CD2AP at the schizont surface. PMID: 29520916
The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. PMID: 11067845
Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro. PMID: 28484055
CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes. PMID: 17213204
The potential signal pathway between PAX2 and CD2AP in the renal interstitial fibrosis disease. PMID: 24471428
Diabetic conditions downregulate the expression of CD2AP in podocytes via PI3-K/Akt signalling. PMID: 24846128
Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. PMID: 26546360
CD2-associated protein and glomerular disease. PMID: 14643126
CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. PMID: 11733379
Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. PMID: 17537921
CD2AP is associated with end-stage renal disease in patients with type 1 diabetes. PMID: 23681557
Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. PMID: 27895104
Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. PMID: 27441654
Molecular cloning, characterization and expression profiles of CD2AP in Nile tilapia (Oreochromis niloticus) responding to Streptococcus agalactiae infection and interaction with CD2 cytoplasmic segment. PMID: 32247045
CD2AP regulates SUMOylation of CIN85 in podocytes. PMID: 22203040
CD2AP is indispensable to multistep cytotoxic process by NK cells. PMID: 19945749
MicroRNA-939 down-regulates CD2-associated protein by targeting promoter in HEK-293T cells. PMID: 26895305
Association of CD2AP with dynamic actin on vesicles in podocytes. PMID: 15956777
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling. PMID: 29729186
Podocyte protection by Angptl3 knockout via inhibiting ROS/GRP78 pathway in LPS-induced acute kidney injury. PMID: 35086056
Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model. PMID: 25887956
Alzheimer's disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment. PMID: 34958910
A CD2AP Mutation Associated with Focal Segmental Glomerulosclerosis in Young Adulthood. PMID: 26997877
The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. PMID: 26358779
Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis. PMID: 28878342
CD2AP links actin to PI3 kinase activity to extend epithelial cell height and constrain cell area. PMID: 31723006
CD2-associated protein participates in podocyte apoptosis via PI3K/Akt signaling pathway. PMID: 26584949
Excessive apoptosis of podocytes caused by dysregulation of microRNA-182-5p and CD2AP confers to an increased risk of diabetic nephropathy. PMID: 31131477
CD2AP mRNA in urinary exosome as biomarker of kidney disease. PMID: 24144866
CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS). PMID: 19131354
CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. PMID: 22706086
CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. PMID: 15910750
The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. PMID: 29734372
Role of CD2-associated protein in albumin overload-induced apoptosis in podocytes. PMID: 21166652
Decreases in podocin, CD2-associated protein (CD2AP) and tensin2 may be involved in albuminuria during septic acute renal failure. PMID: 21799297
miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome. PMID: 30756418
CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes using overexpression and RNA interference technique. PMID: 16088078
TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes. PMID: 19679673
Decreased gene expression of CD2AP in Chinese patients with sporadic Alzheimer's disease. PMID: 28392172
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. PMID: 18753381
[Role of CD2-associated protein in podocyte differentiation.]. PMID: 18288369
CD2AP, dendrin, and cathepsin L in the kidney. PMID: 26506476
CD2-associated protein/phosphoinositide 3-kinase signaling has a preventive role in angiotensin II-induced podocyte apoptosis. PMID: 27590856
CD2AP and p130Cas localize to different F-actin structures in podocytes. PMID: 11553524
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. PMID: 31412248
Role for CD2AP and other endocytosis-associated proteins in enteropathogenic Escherichia coli pedestal formation. PMID: 20515931
EGF-recruited JunD/c-fos complexes activate CD2AP gene promoter and suppress apoptosis in renal tubular epithelial cells. PMID: 19095050
All-trans retinoic acid up-regulates the human CD2AP gene expression through Sp1/Sp3 binding sites. PMID: 25957888
Bin1 and CD2AP polarize Aβ generation in neurons. PMID: 27993940
CD2-associated protein is widely expressed and differentially regulated during embryonic development. PMID: 18177421
Expression profile of nephrin, podocin, and CD2AP in Chinese children with MCNS and IgA nephropathy. PMID: 16941146
DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes. PMID: 35389423
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. PMID: 10997929
Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy. PMID: 24511139
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. PMID: 12530983
The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte. PMID: 16501493
Clues to CD2-associated protein involvement in cytokinesis. PMID: 15800069
Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein. PMID: 16707503
Analysis of recessive CD2AP and ACTN4 mutations in steroid-resistant nephrotic syndrome. PMID: 19956976
Role of CD2-associated protein in podocyte apoptosis and proteinuria induced by angiotensin II. PMID: 24986244
The interdependence of the Rho GTPases and apicobasal cell polarity. PMID: 25469537
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. PMID: 12559036
ALDH, CA I, and CD2AP: novel, diagnostically useful immunohistochemical markers to identify erythroid precursors in bone marrow biopsy specimens. PMID: 22180476
Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*. PMID: 23663663
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. PMID: 12832477
Ginseng Total Saponin Attenuates Podocyte Apoptosis Induced by Diabetic Conditions Through the Recovery of CD2-Associated Protein. PMID: 30601089
The high resolution NMR structure of the third SH3 domain of CD2AP. PMID: 17922258
Shenqi granule upregulates CD2AP and α-actinin4 and activates autophagy through regulation of mTOR/ULK1 pathway in MPC5 cells. PMID: 36442763
Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. PMID: 29702546
Re-characterization of the Glomerulopathy in CD2AP Deficient Mice by High-Resolution Helium Ion Scanning Microscopy. PMID: 28814739
Regulation of CD2-associated protein influences podocyte endoplasmic reticulum stress-mediated apoptosis induced by albumin overload. PMID: 21679752
Genetics of Alzheimer's disease. PMID: 25311924
Epithelial junctions and Rho family GTPases: the zonular signalosome. PMID: 25483301
Downregulation of CD2-associated protein impaired the physiological functions of podocytes. PMID: 19306938
Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation. PMID: 17713465
CREB and Sp1 regulate the human CD2AP gene promoter activity in renal tubular epithelial cells. PMID: 18396147
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. PMID: 21911934
Recessive mutation in CD2AP causes focal segmental glomerulosclerosis in humans and mice. PMID: 30612599
Genomics of Alzheimer Disease: A Review. PMID: 27135718
miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia. PMID: 32764959
Association of the CD2AP locus with cognitive functioning among middle-aged individuals with a family history of Alzheimer's disease. PMID: 33578194
The first report of CD2 associated protein gene, in a teleost (Rock bream, Oplegnathus fasciatus): An investigation of the immune response upon infection with several pathogens. PMID: 28535972
Phosphorylation of key podocyte proteins and the association with proteinuric kidney disease. PMID: 32686524
Cyclosporine A induced histological changes of Cathepsin L and CD2AP expression in renal glomeruli and tubules. PMID: 26975192
IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. PMID: 16672319
Bta-miR-199a-3p Inhibits LPS-Induced Inflammation in Bovine Mammary Epithelial Cells via the PI3K/AKT/NF-κB Signaling Pathway. PMID: 36359915
Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue. PMID: 22953501
CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production. PMID: 24218450
LIM and SH3 protein 1 (LASP-1): A novel link between the slit membrane and actin cytoskeleton dynamics in podocytes. PMID: 32086849
[Effect and molecular mechanism of interferon-α on podocyte apoptosis induced by hepatitis B virus X protein]. PMID: 31506156
Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis. PMID: 34623609
CD2-associated protein directly interacts with the actin cytoskeleton. PMID: 12217865
A plasma proteogenomic signature for fibromuscular dysplasia. PMID: 31424497
CD2AP at the junction of nephropathy and Alzheimer's disease., PMID:40462155
CD2AP shapes a stromal reduced tumor microenvironment and contributes to immunotherapy in gastric cancer., PMID:40399857
Integrated Analysis of Disulfidptosis-Related Genes Identifies CD2AP as a Potential Therapeutic Target for Hepatocellular Carcinoma., PMID:40362690
Integrated bioinformatic analysis of immune infiltration and disulfidptosis related gene subgroups in type A aortic dissection., PMID:40258895
Effects of steroid-resistant nephrotic syndrome serum on AA pathway in podocytes cultured in 3D in vitro glomerular model., PMID:40229314
Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease., PMID:40215969
Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for LUAD patients by comprehensive multi-omics analysis., PMID:40214854
Inhibition of LINC00707/miR-223-3p/FKBP5 axis has a protective effect on diabetic kidney disease., PMID:40114624
Sexual dimorphism in cerebrovascular dysfunction: The pivotal role of endothelial CD2AP in Alzheimer's disease., PMID:40112772
Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data., PMID:40050982
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction., PMID:39892386
APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer's disease., PMID:39744941
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels., PMID:39720588
CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation., PMID:39696695
Microglial CD2AP deficiency exerts protection in an Alzheimer's disease model of amyloidosis., PMID:39695808
Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies., PMID:39655660
Consistent genes associated with structural changes in clinical Alzheimer's disease spectrum., PMID:39554844
Reconstitution of Arp2/3-nucleated actin assembly with proteins CP, V-1, and CARMIL., PMID:39437783
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin., PMID:39406515
CD2AP promotes the progression of glioblastoma multiforme via TRIM5-mediated NF-kB signaling., PMID:39353894
Predictive value analysis of the interaction network of Tks4 scaffold protein in colon cancer., PMID:39234565
CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain., PMID:39211110
Renal Protective Effect of Boeravinone B against Diabetic Nephropathy Rats via Inhibition of The Inflammatory and JAK2/STAT3 Signalling Pathway., PMID:39154235
Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity., PMID:39146503
The Role of Changes in the Expression of Inflammation-Associated Genes in the Variants of Cerebral Small Vessel Disease., PMID:39125683
The Immunosuppressive Drug LF15-0195 Acts Also on Glomerular Lesions, by a Change in Cytoskeleton Distribution in Podocyte., PMID:39074452
Acupuncture improve proteinuria in diabetic kidney disease rats by inhibiting ferroptosis and epithelial-mesenchymal transition., PMID:39071725
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation., PMID:39061076
Human cytomegalovirus pUL135 protein affects endothelial cell function via CD2AP in Kawasaki disease., PMID:39025135
Comprehensive analysis of disulfidptosis-related genes reveals the effect of disulfidptosis in ulcerative colitis., PMID:38977802
Reconstitution of Arp2/3-Nucleated Actin Assembly with CP, V-1 and CARMIL., PMID:38798690
Comprehensive Urinary Proteome Profiling Analysis Identifies Diagnosis and Relapse Surveillance Biomarkers for Bladder Cancer., PMID:38787199
Hypoxia-inducible factor-1α attenuates renal podocyte injury in male rats in a simulated high-altitude environment by upregulating Krüppel-like factor 4 expression., PMID:38774964
Biophysical characterization and insights into the oligomeric nature of CD2-associated protein., PMID:38765876
TurboID mapping reveals the exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata., PMID:38747635
Indoxyl Sulfate Aggravates Podocyte Damage through the TGF-β1/Smad/ROS Signalling Pathway., PMID:38735279
Disulfidptosis-related signature elucidates the prognostic, immunologic, and therapeutic characteristics in ovarian cancer., PMID:38694875
CD2AP is a potential prognostic biomarker of renal clear cell carcinoma., PMID:38457255
Noncanonical function of folate through folate receptor 1 during neural tube formation., PMID:38388461
Hepatitis B virus-targeting sodium taurocholate cotransporting polypeptide mediates HBV infection and damage in human renal podocytes., PMID:38315030
Knowledge domains and emerging trends of Genome-wide association studies in Alzheimer's disease: A bibliometric analysis and visualization study from 2002 to 2022., PMID:38241287
Collapsing Glomerulopathy in a Patient with a TRPC6 Mutation Presenting as Rapidly Progressive Glomerulonephritis: A Case Report and Review of the Literature., PMID:38231721
Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial-Mesenchymal Transition (EMT) Process., PMID:37894817
Pan-cancer genetic analysis of disulfidptosis-related gene set., PMID:37879141
[Effects and mechanisms of total flavones of Abelmoschus manihot in inhibiting podocyte necroptosis and renal fibrosis in diabetic kidney disease]., PMID:37802782
Angiopoietin-like protein 3 deficiency combined with valsartan administration protects better against podocyte damage in streptozotocin-induced diabetic nephropathy mice., PMID:37724955
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis., PMID:37689694
Ocular manifestations of the genetic causes of focal and segmental glomerulosclerosis., PMID:37578539
Non-canonical function of folate/folate receptor 1 during neural tube formation., PMID:37503108
RhoGAP6 interacts with COPI to regulate protein transport., PMID:37409526
For research use only. Not for human or drug use.
