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Recombinant Human STAM Protein, N-His-SUMO

Catalog #:   YHJ33102 Specific References (129) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q92783
Protein length: Pro2-Thr141
Overview

Catalog No.

YHJ33102

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Pro2-Thr141

Predicted molecular weight

27.94 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q92783

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

STAM-1, STAM1, Signal transducing adapter molecule 1, STAM

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human STAM protein
References

STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic potential in pancreatic cancer. PMID: 36089485

STAM-binding protein regulates melanoma metastasis through SLUG stabilization. PMID: 30454887

Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer. PMID: 34803493

PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer. PMID: 33046573

Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis. PMID: 32785653

High-throughput screening of functional deubiquitinating enzymes in autophagy. PMID: 32453962

Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer. PMID: 33638902

Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT Pathway. PMID: 34506952

ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. PMID: 25819836

Cis-regulatory sequences in plants: Their importance, discovery, and future challenges. PMID: 34918159

STAM/EAST/Hbp adapter proteins--integrators of signalling pathways. PMID: 11728436

HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway. PMID: 31796646

Biopolymeric nanoparticles. PMID: 27877319

The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage. PMID: 26601948

Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. PMID: 32385406

Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice. PMID: 30194503

STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. PMID: 19054391

Advances of engineered extracellular vesicles-based therapeutics strategy. PMID: 36277506

STAM-AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH. PMID: 17078930

The Hrs/STAM complex in the downregulation of receptor tyrosine kinases. PMID: 15713877

Ubiquitin and endocytic protein sorting. PMID: 16250899

Plant Enhancers: A Call for Discovery. PMID: 27593567

STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. PMID: 9133424

The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development. PMID: 20422006

Biocompatibility of titanium from the viewpoint of its surface. PMID: 35990790

Ipragliflozin attenuates non-alcoholic steatohepatitis development in an animal model. PMID: 35192632

STAM and Hrs down-regulate ciliary TRP receptors. PMID: 17581863

Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. PMID: 9407053

STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. PMID: 12972556

Large three-dimensional cell constructs for tissue engineering. PMID: 34408551

STAM transports STING oligomers into extracellular vesicles, down-regulating the innate immune response. PMID: 36946680

Psychopathology in premanifest C9orf72 repeat expansion carriers. PMID: 34583943

Latest advances in extracellular vesicles: from bench to bedside. PMID: 31447954

Endocytosis: the DUB version. PMID: 16996268

Profiling the orphan enzymes. PMID: 24906382

DE-STRESS: a user-friendly web application for the evaluation of protein designs. PMID: 34908138

STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. PMID: 36797476

Interaction of gold nanoparticles with proteins and cells. PMID: 27877797

Biomimetic materials based on zwitterionic polymers toward human-friendly medical devices. PMID: 36117516

Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro. PMID: 25564854

Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins. PMID: 24555901

Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. PMID: 10383417

Bronchoalveolar lavage. PMID: 1858410

Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions. PMID: 36518982

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. PMID: 28492230

Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex. PMID: 20736164

Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review. PMID: 31068982

The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome. PMID: 33253913

Characterization of mini-protein S, a recombinant variant of protein S that lacks the sex hormone binding globulin-like domain. PMID: 9461535

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. PMID: 22275353

The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. PMID: 10231582

Association with Hrs is required for the early endosomal localization, stability, and function of STAM. PMID: 15113837

Breaking up and making up: The secret life of the vacuolar H+ -ATPase. PMID: 28247968

The interaction of protein S with the phospholipid surface is essential for the activated protein C-independent activity of protein S. PMID: 8883277

An SH3 binding motif within the nucleocapsid protein of porcine reproductive and respiratory syndrome virus interacts with the host cellular signaling proteins STAMI, TXK, Fyn, Hck, and cortactin. PMID: 25882913

6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis. PMID: 32392051

A CRISPR/Cas9 engineered MplS504N mouse model recapitulates human myelofibrosis. PMID: 35999261

An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. PMID: 14755250

Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination. PMID: 21448666

Identifying DNA methylation in a nanochannel. PMID: 27877910

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. PMID: 12551915

A review of the genetic relation between migraine and epilepsy. PMID: 18197881

Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein. PMID: 9628846

TIM-1 Ubiquitination Mediates Dengue Virus Entry. PMID: 29742433

A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. PMID: 16771824

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging. PMID: 33658508

Evolution and origin of HRS, a protein interacting with Merlin, the Neurofibromatosis 2 gene product. PMID: 20054405

Can we define an infant's need from the composition of human milk? PMID: 23842459

Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. PMID: 33802238

Recent developments in effector biology of filamentous plant pathogens. PMID: 20374248

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia. PMID: 26463423

Signaling from the IL-2 receptor to the nucleus. PMID: 9620644

Epidemiology of carbapenem-resistant and carbapenemase-producing Enterobacterales in the Netherlands 2017-2019. PMID: 35397546

AMSH is an endosome-associated ubiquitin isopeptidase. PMID: 15314065

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation. PMID: 26232618

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. PMID: 11483516

STAM2, a new member of the STAM family, binding to the Janus kinases. PMID: 10899310

Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis. PMID: 25607821

Chromatin conversations: mechanisms and implications of paramutation. PMID: 15211355

VHS domain -- a longshoreman of vesicle lines. PMID: 11911875

Early‑onset epilepsy and microcephaly‑capillary malformation syndrome caused by a novel STAMBP mutation in a Chinese boy. PMID: 31638258

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces. PMID: 27877525

Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation. PMID: 31004702

A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity. PMID: 31275460

Artificial extracellular matrix for embryonic stem cell cultures: a new frontier of nanobiomaterials. PMID: 27877321

Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization. PMID: 34248421

Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. PMID: 16431367

Effective lead selection for improved protein production in Aspergillus niger based on integrated genomics. PMID: 18824119

An NMRA-Like Protein Regulates Gene Expression in Phytophthora capsici to Drive the Infection Cycle on Tomato. PMID: 29419371

Towards targeted therapy for infant acute lymphoblastic leukaemia. PMID: 16445826

Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking. PMID: 28218281

Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer. PMID: 22370639

Improved anti-cancer effect of epidermal growth factor-gold nanoparticle conjugates by protein orientation through site-specific mutagenesis. PMID: 34512175

Hrs and hbp: possible regulators of endocytosis and exocytosis. PMID: 11243842

Cerebral venous and sinus thrombosis: incidence and causes. PMID: 12760187

Glucose-responsive hydrogel electrode for biocompatible glucose transistor. PMID: 28179956

Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine. PMID: 35783540

Recent advances in the understanding of interleukin-2 signal transduction. PMID: 9793823

dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster. PMID: 17664083

Role of Tiam 1 in Rac-mediated signal transduction pathways. PMID: 9053294

The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking. PMID: 20604899

A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. PMID: 2677252

Genetics of migraine: an update with special attention to genetic comorbidity. PMID: 18451712

Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. PMID: 14563850

Allelic variants of the NLR protein Rpi-chc1 differentially recognize members of the Phytophthora infestans PexRD12/31 effector superfamily through the leucine-rich repeat domain. PMID: 33882622

Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. PMID: 17403676

Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics. PMID: 34304246

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. PMID: 24790097

Do unintended antisense transcripts contribute to sense cosuppression in plants? PMID: 10087927

Protocol for Chromatin Immunoprecipitation of Meiotic-Stage-Specific Tomato Anthers. PMID: 30208267

Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. PMID: 16716190

Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia. PMID: 32488115

Actin bundle architecture and mechanics regulate myosin II force generation. PMID: 33798565

Role of toll-like receptors 3, 4 and 7 in cellular uptake and response to titanium dioxide nanoparticles. PMID: 27877566

Paramutation: an encounter leaving a lasting impression. PMID: 15949762

Endofin recruits TOM1 to endosomes. PMID: 14613930

Interaction of poly(ethylene glycol)-conjugated phospholipids with supported lipid membranes and their influence on protein adsorption. PMID: 27877914

Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. PMID: 17079730

Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells. PMID: 30360403

Granular dot-like staining with MLH1 immunohistochemistry is a clone-dependent artefact. PMID: 31402167

Interactive effect of reduced pollen availability and Varroa destructor infestation limits growth and protein content of young honey bees. PMID: 23439242

Pymetrozine activates TRPV channels of brown planthopper Nilaparvata lugens. PMID: 30744899

Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. PMID: 15828871

Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice. PMID: 9091585

Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. PMID: 23542699

C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm. PMID: 25108196

Structural and mechanistic aspects of Janus kinases: how the two-faced god wields a double-edged sword. PMID: 9475661

Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger. PMID: 20922374

Sulfate-modified nanosized polystyrene impairs memory by inhibiting ionotropic glutamate receptors and the cAMP-response element binding protein (CREB) pathway in Caenorhabditis elegans. PMID: 36868277

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human STAM Protein, N-His-SUMO [YHJ33102]
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