Catalog No.
YHE92402
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn66-Glu201
Predicted molecular weight
17.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52566
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARHGDIB, Rho-GDI beta, Rho GDP-dissociation inhibitor 2, RAP1GN1, Rho GDI 2, GDIA2, GDID4, Ly-GDI
KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. PMID: 34006303
Podocytes and autophagy: a potential therapeutic target in lupus nephritis. PMID: 30755075
Identification of proteomic signatures associated with lung cancer and COPD. PMID: 23665002
Systematic investigation of biomarker-like role of ARHGDIB in breast cancer. PMID: 32176626
Antibodies Against ARHGDIB and ARHGDIB Gene Expression Associate With Kidney Allograft Outcome. PMID: 31651716
Antibodies against ARHGDIB are associated with long-term kidney graft loss. PMID: 31194283
The hematopoietic cell-specific Rho GTPase inhibitor ARHGDIB/D4GDI limits HIV type 1 replication. PMID: 21936715
ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability. PMID: 31016112
Comprehensive analysis of miRNA-mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse. PMID: 34844599
ARHGDIB and AT1R autoantibodies are differentially related to the development and presence of chronic antibody-mediated rejection and fibrosis in kidney allografts. PMID: 33358038
Screening anlotinib responders via blood-based proteomics in non-small cell lung cancer. PMID: 35867072
PD-L1 enhances migration and invasion of trophoblasts by upregulating ARHGDIB via transcription factor PU.1. PMID: 36138021
The Dual Function of RhoGDI2 in Immunity and Cancer. PMID: 36835422
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus. PMID: 34481194
Placenta-specific novel splice variants of Rho GDP dissociation inhibitor β are highly expressed in cancerous cells. PMID: 23206989
Adenosine Inhibits Ovarian Cancer Growth Through Regulating RhoGDI2 Protein Expression. PMID: 32109988
GM3 signals regulating TNF-alpha expression are mediated by Rictor and Arhgdib in mouse melanoma B16 cells. PMID: 18523362
Pathways of metastasis suppression in bladder cancer. PMID: 20013033
RhoGDI2 as a therapeutic target in cancer. PMID: 20001211
Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs. PMID: 28662216
Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma. PMID: 17897297
SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies. PMID: 35835296
Therapeutic effects of Euphorbia Pekinensis and Glycyrrhiza glabra on Hepatocellular Carcinoma Ascites Partially Via Regulating the Frk-Arhgdib-Inpp5d-Avpr2-Aqp4 Signal Axis. PMID: 28165501
Unconventional myosin VIIA promotes melanoma progression. PMID: 29361540
Characterizing isomiR variants within the microRNA-34/449 family. PMID: 28192603
LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis. PMID: 21695085
Proteomic characterization of early lung response to breast cancer metastasis in mice. PMID: 30763573
An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). PMID: 26707877
RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation. PMID: 17826660
Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. PMID: 10433515
TAT-RhoGDI2, a novel tumor metastasis suppressor fusion protein: expression, purification and functional evaluation. PMID: 25142698
Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis. PMID: 26499913
RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer. PMID: 25516960
CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2. PMID: 34437633
Shotgun proteome analysis of protein cleavage in apoptotic cells. PMID: 15846839
Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays. PMID: 25073739
Comparison of Two Strategies to Generate Antigen-Specific Human Monoclonal Antibodies: Which Method to Choose for Which Purpose? PMID: 34017336
Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. PMID: 8356058
Study on the transcriptome for breast muscle of chickens and the function of key gene RAC2 on fibroblasts proliferation. PMID: 33676413
Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells. PMID: 34773852
Rictor regulates cell migration by suppressing RhoGDI2. PMID: 22777355
A methylation-driven gene panel predicts survival in patients with colon cancer. PMID: 34184409
Novel Diagnostic Biomarkers for High-Grade Serous Ovarian Cancer Uncovered by Data-Independent Acquisition Mass Spectrometry. PMID: 35939567
Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. PMID: 11114252
Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma. PMID: 25573518
Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma. PMID: 25428551
Association of D4-GDI expression with breast cancer progression. PMID: 22674302
Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors. PMID: 23149915
LyGDI is a promising biomarker for ovarian cancer. PMID: 20375790
PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer. PMID: 21986528
Anti-D4GDI antibodies activate platelets in vitro: a possible link with thrombocytopenia in primary antiphospholipid syndrome. PMID: 31262358
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. PMID: 26414765
Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. PMID: 24788627
VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance. PMID: 24585459
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway. PMID: 30192158
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. PMID: 19276387
RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells. PMID: 24721928
Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk. PMID: 29079706
Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis. PMID: 26469087
Differential proteomic analysis of a highly metastatic variant of human breast cancer cells using two-dimensional differential gel electrophoresis. PMID: 20155427
Identification of ubiquitin target proteins using cell-based arrays. PMID: 17894482
PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity. PMID: 22469974
Causes of Positive Pretransplant Crossmatches in the Absence of Donor-Specific Anti-Human Leukocyte Antigen Antibodies: A Single-Center Experience. PMID: 33536364
Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. PMID: 19321744
Regulation of apoptosis by peptides of fibronectin in human monocytes. PMID: 16502259
Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis. PMID: 10381642
Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes. PMID: 25623267
Invasion and metastasis models for studying RhoGDI2 in bladder cancer. PMID: 18374168
D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness. PMID: 16740694
Clinical significance of Rho GDP dissociation inhibitor 2 in colorectal carcinoma. PMID: 21698524
Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis. PMID: 20596634
RhoGDI2 is expressed in human trophoblasts and involved in their migration by inhibiting the activation of RAC1. PMID: 24554735
Overexpression of RhoGDI2 correlates with tumor progression and poor prognosis in colorectal carcinoma. PMID: 21861235
Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach. PMID: 28148498
Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells. PMID: 18809735
[MALDI-TOF and SELDI-TOF analysis: "tandem" techniques to identify potential biomarker in fibromyalgia]. PMID: 22257917
RhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expression. PMID: 21752536
Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. PMID: 15173088
RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling. PMID: 31362179
RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. PMID: 22406535
RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer. PMID: 19351766
Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway. PMID: 23349340
TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator. PMID: 10947073
Freeze-thawing single human embryonic stem cells induce e-cadherin and actin filament network disruption via g13 signaling. PMID: 22227712
14-3-3σ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells. PMID: 24185104
GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells. PMID: 21518140
Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. PMID: 10664460
D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells. PMID: 11989976
Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. PMID: 16103083
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. PMID: 8626669
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids. PMID: 14505793
Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor. PMID: 8752894
Proteomics-based strategy to delineate the molecular mechanisms of RhoGDI2-induced metastasis and drug resistance in gastric cancer. PMID: 22364609
LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane. PMID: 15057873
Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. PMID: 9490022
For research use only. Not for human or drug use.
