Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination. PMID: 34139860
TM4SF1, a binding protein of DVL2 in hepatocellular carcinoma, positively regulates beta-catenin/TCF signalling. PMID: 31876386
WNT/PCP signaling pathway and human cancer (review). PMID: 16273260
CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling. PMID: 35509083
CD47-Mediated Hedgehog/SMO/GLI1 Signaling Promotes Mesenchymal Stem Cell Immunomodulation in Mouse Liver Inflammation. PMID: 33765345
PP5 (PPP5C) is a phosphatase of Dvl2. PMID: 29426949
Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates. PMID: 35867833
USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification. PMID: 31340145
Dvl2 facilitates the coordination of NF-κB and Wnt signaling to promote colitis-associated colorectal progression. PMID: 34807493
Down-regulation of dishevelled-2 inhibits cell proliferation and invasion in hepatoblastoma. PMID: 29528187
Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling. PMID: 34609794
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma. PMID: 28119087
FOXM1/DVL2/Snail axis drives metastasis and chemoresistance of colorectal cancer. PMID: 33291076
Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. PMID: 34691249
HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression. PMID: 35121725
Verification of EZH2 as a druggable target in metastatic uveal melanoma. PMID: 32127003
WWOX activation by toosendanin suppresses hepatocellular carcinoma metastasis through JAK2/Stat3 and Wnt/β-catenin signaling. PMID: 34015398
Aquaporin 9 inhibits growth and metastasis of hepatocellular carcinoma cells via Wnt/β-catenin pathway. PMID: 31969493
Characterization of the aberrant splicing of DVL2 induced by cancer-associated SF3B1 mutation. PMID: 33561744
Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. PMID: 35012409
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling. PMID: 36398662
APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription. PMID: 25622892
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor. PMID: 31867777
Chondrocyte Polarity During Endochondral Ossification Requires Protein-Protein Interactions Between Prickle1 and Dishevelled2/3. PMID: 34423861
Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs. PMID: 32776193
Canine DVL2 variant contributes to brachycephalic phenotype and caudal vertebral anomalies. PMID: 33599851
Stau1 regulates Dvl2 expression during myoblast differentiation. PMID: 22166206
MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression. PMID: 33577018
Different behaviour of DVL1, DVL2, DVL3 in astrocytoma malignancy grades and their association to TCF1 and LEF1 upregulation. PMID: 30468298
Study of microRNAs targeted Dvl2 on the osteoblasts differentiation of rat BMSCs in hyperlipidemia environment. PMID: 29226968
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. PMID: 27599467
Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression. PMID: 33964281
ASPM promotes hepatocellular carcinoma progression by activating Wnt/β-catenin signaling through antagonizing autophagy-mediated Dvl2 degradation. PMID: 34428354
DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/β-catenin signaling by DVL2. PMID: 35187752
Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia. PMID: 33205477
The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling. PMID: 32888647
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PMID: 22655072
Cell cortex regulation by the planar cell polarity protein Prickle1. PMID: 35512799
p120-catenin in canonical Wnt signaling. PMID: 28276699
Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer. PMID: 31723073
Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. PMID: 34299191
GABARAPL1 negatively regulates Wnt/β-catenin signaling by mediating Dvl2 degradation through the autophagy pathway. PMID: 21691068
Loss of lncRNA-SNHG7 Promotes the Suppression of Hepatic Stellate Cell Activation via miR-378a-3p and DVL2. PMID: 31272073
Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2. PMID: 32737219
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. PMID: 23371553
TBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling. PMID: 31963474
DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis. PMID: 26892600
The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly. PMID: 28614913
The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. PMID: 16263762
Dishevelled: A masterful conductor of complex Wnt signals. PMID: 29559363
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. PMID: 22609948
Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. PMID: 20663899
Dishevelled2 is a stable protein during early zebrafish development. PMID: 21663448
Dynamic recruitment of axin by Dishevelled protein assemblies. PMID: 17606995
Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct? PMID: 28603713
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry. PMID: 29796181
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly. PMID: 36342472
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. PMID: 23396968
Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells. PMID: 23353182
The Adenoviral E1B-55k Protein Present in HEK293 Cells Mediates Abnormal Accumulation of Key WNT Signaling Proteins in Large Cytoplasmic Aggregates. PMID: 34946869
The Research of Dishevelled-2 in Dental Implant Osseointegration of Hyperlipidemic Rats. PMID: 29253039
Association of DVL2 and AXIN2 gene polymorphisms with cleft lip with or without cleft palate in a Polish population. PMID: 22887353
MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2. PMID: 21487968
Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. PMID: 26013125
Dvl2 silencing in postdevelopmental cells results in aberrant cell membrane activity and actin disorganization. PMID: 15593083
WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity. PMID: 34733849
TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2. PMID: 29867201
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism. PMID: 36357669
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction. PMID: 37014927
A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host. PMID: 32631335
The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation. PMID: 24727453
Correction: TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2. PMID: 30158671
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders. PMID: 32092816
Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation. PMID: 25558878
PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin. PMID: 33116587
WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma. PMID: 30877610
Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. PMID: 8887313
Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects. PMID: 34274973
Dishevelled family proteins (DVL1-3) expression in intrauterine growth restriction (IUGR) placentas. PMID: 33485290
IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling. PMID: 31101875
Residue 6.43 defines receptor function in class F GPCRs. PMID: 34168128
Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes-Brocks syndrome 2. PMID: 36066768
The Autophagy Regulator p62 Controls PTEN-Dependent Ciliogenesis. PMID: 32587859
Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin. PMID: 27561318
Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway. PMID: 28447744
Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. PMID: 29116181
Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization. PMID: 30808893
The polycystin complex mediates Wnt/Ca(2+) signalling. PMID: 27214281
Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study. PMID: 31755579
Sulfur-Coordinated Organoiridium(III) Complexes Exert Breast Anticancer Activity via Inhibition of Wnt/β-Catenin Signaling. PMID: 33244858
Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin. PMID: 36383195
[Expression of dishevelled-2 in cartilage of rheumatoid arthritis and its effect on cartilage destruction]. PMID: 30180453
Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Fei Jin Sheng Formula in the Treatment of Lung Cancer. PMID: 37138492
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. PMID: 22106258
Ascorbic acid regulates mouse spermatogonial stem cell proliferation in a Wnt/β-catenin/ROS signaling dependent manner. PMID: 35279534
Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2. PMID: 24616100
Inhibition of disheveled-2 resensitizes cisplatin-resistant lung cancer cells through down-regulating Wnt/β-catenin signaling. PMID: 27432651
Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis. PMID: 34059062
[Disheveled 2 around the implant at an early stage of hyperlipidemic rats]. PMID: 29595002
The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy. PMID: 25825496
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation. PMID: 32601235
DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway. PMID: 32900645
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. PMID: 12421720
Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation. PMID: 25568338
Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis. PMID: 30804458
The Role of Wnt/β-Catenin Pathway Mediators in Aortic Valve Stenosis. PMID: 33015048
Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. PMID: 22892949
Structural insight into small molecule action on Frizzleds. PMID: 31964872
Potential role and prognostic importance of dishevelled-2 in epithelial ovarian cancer. PMID: 28513833
Variants identified in PTK7 associated with neural tube defects. PMID: 30689296
c21orf59/kurly Controls Both Cilia Motility and Polarization. PMID: 26904945
Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/β-catenin axis. PMID: 36323918
Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine. PMID: 29675451
Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma. PMID: 27083564
Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia. PMID: 27086035
High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PMID: 24427302
Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway. PMID: 32201078
Dishevelled localization and function are differentially regulated by structurally distinct sterols., PMID:40524961
LRRFIP1 enhances the Wnt/β-catenin pathway by binding to DVLs in myelodysplastic syndrome., PMID:40420163
Ishophloroglucin A Isolated From Ishige okamurae Stimulates Osteoblast Differentiation Through Activation of the Bone Morphogenetic Protein and Wnt/β-Catenin Signaling Pathways in MC3T3-E1 Cells., PMID:40343669
TFE3-rearranged ossifying fibromyxoid tumors are uniquely negative for glycoprotein non-metastatic melanoma protein B: A study of 13 TFE3-rearranged mesenchymal tumors., PMID:40189028
Aptamer inhibits P-glycoprotein efflux function via the Wnt/β-catenin signaling pathway., PMID:40168709
Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5'tRFAla/DVL/β-catenin pathway inhibition., PMID:40128187
Functional Evaluation of Neural Tube Defect-Related Missense Mutations Using In Silico Methods., PMID:39950581
SENP2 as a critical regulator in liver ischemia-reperfusion injury., PMID:39890015
Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf-2/HO-1/NQO1, Ki-67 and Wnt Signaling Pathways., PMID:39812109
Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling., PMID:39652469
Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury., PMID:39644526
GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification., PMID:39560901
Exploring DIX-DIX Homo- and Hetero-Oligomers in Wnt Signaling with AlphaFold2., PMID:39404409
Autophagy controls neuronal differentiation by regulating the WNT-DVL signaling pathway., PMID:39385328
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP., PMID:39366759
Intracellular Construction of Organelle-like Compartments Facilitates Metabolic Flux in Escherichia coli., PMID:39230507
Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation., PMID:39223191
[Lycium barbarum miR2911-loaded exosomes promote spermatogenic function recovery in rats with non-obstructive azoospermia by regulating Wnt/β-catenin signaling pathways]., PMID:39212356
ZNF460-mediated upregulation of APCDD1L-DT promotes cholangiocarcinoma development by inhibiting the ubiquitin-mediated degradation of DVL2., PMID:39210030
Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling., PMID:39172791
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
The upregulation of POLR3G correlates with increased malignancy of bladder urothelium., PMID:39039528
Iloperidone and Temozolomide Synergistically Inhibit Growth, Migration and Enhance Apoptosis in Glioblastoma Cells., PMID:38927341
The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure., PMID:38877839
Dishevelled localization and function are differentially regulated by structurally distinct sterols., PMID:38798572
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF., PMID:38714795
RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma., PMID:38576051
Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations., PMID:38558095
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis., PMID:38433252
Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p., PMID:38365722
Properties of biomolecular condensates defined by Activator of G-protein Signaling 3., PMID:38264908
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model., PMID:38041203
Disheveled-1 Interacts with Claudin-5 and Contributes to Norrin-Induced Endothelial Barrier Restoration., PMID:37830616
HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34+ hematopoietic progenitor cells., PMID:37772824
Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression., PMID:37703992
Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression., PMID:37534375
ASPM overexpression enhances cellular proliferation and migration and predicts worse prognosis for papillary renal cell carcinoma., PMID:37309171
Dishevelled segment polarity protein 2 promotes gastric cancer progression through Wnt/β-catenin pathway., PMID:37257286
Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Fei Jin Sheng Formula in the Treatment of Lung Cancer., PMID:37138492
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction., PMID:37014927
Dishevelled 2 regulates cancer cell proliferation and T cell mediated immunity in HER2-positive breast cancer., PMID:36809986
Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori., PMID:36720664
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling., PMID:36398662
Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin., PMID:36383195
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism., PMID:36357669
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly., PMID:36342472
Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/β-catenin axis., PMID:36323918
Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes-Brocks syndrome 2., PMID:36066768
High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis., PMID:35971121
DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer., PMID:35965516
For research use only. Not for human or drug use.
