Genetics, TREX1 Mutations. PMID: 31335009
TREX1 plays multiple roles in human diseases. PMID: 35468328
ER-directed TREX1 limits cGAS activation at micronuclei. PMID: 33476576
The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. PMID: 35127372
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. PMID: 28598415
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion. PMID: 34551315
TREX1 as a Novel Immunotherapeutic Target. PMID: 33868310
Trex1 prevents cell-intrinsic initiation of autoimmunity. PMID: 18724932
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. PMID: 33606975
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy. PMID: 34382907
Aicardi-Goutières Syndrome. PMID: 20301648
Structural basis of human TREX1 DNA degradation and autoimmune disease. PMID: 35879334
STING inhibitors target the cyclic dinucleotide binding pocket. PMID: 34099558
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. PMID: 36070769
The abscopal effect of radiation therapy. PMID: 33726502
p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression. PMID: 36638783
Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1. PMID: 35403787
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation. PMID: 31874111
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. PMID: 29907693
Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. PMID: 23962476
The interferon response to intracellular DNA: why so many receptors? PMID: 35349719
Human TDP1, APE1 and TREX1 repair 3'-DNA-peptide/protein cross-links arising from abasic sites in vitro. PMID: 34997539
TREX1 Deficiency Induces ER Stress-Mediated Neuronal Cell Death by Disrupting Ca2+ Homeostasis. PMID: 30799039
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. PMID: 21478870
A diverse range of gene products are effectors of the type I interferon antiviral response. PMID: 33854495
cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE. PMID: 35239517
Occlusive retinal vasculitis: novel insights into causes, pathogenesis and treatment. PMID: 36217001
The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. PMID: 29593264
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. PMID: 35973990
Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes. PMID: 28334850
Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion. PMID: 24183309
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. PMID: 31475890
TREX1 As a Potential Therapeutic Target for Autoimmune and Inflammatory Diseases. PMID: 26371324
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. PMID: 31455522
Measuring TREX1 and TREX2 exonuclease activities. PMID: 20301334
Hereditary Dystonia Overview. PMID: 33006365
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma. PMID: 28297665
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex. PMID: 25855793
Clinical and molecular phenotype of Aicardi-Goutieres syndrome. PMID: 32615442
Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA. PMID: 27812953
TREX1 - Apex predator of cytosolic DNA metabolism. PMID: 23979357
Monogenic Lupus. PMID: 36696898
The TREX1 C-terminal region controls cellular localization through ubiquitination. PMID: 31326279
Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks. PMID: 25848017
TREX1 variants in Sjogren's syndrome related lymphomagenesis. PMID: 35699195
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. PMID: 29941221
Systematic Review of Cerebral Phenotypes Associated With Monogenic Cerebral Small-Vessel Disease. PMID: 23622384
TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation. PMID: 25731743
Aicardi-Goutières syndrome. PMID: 33823133
Human disease phenotypes associated with mutations in TREX1. PMID: 27881153
The spatial organization of cGAS-TREX1 interactions. PMID: 33892200
Verification of TREX1 as a promising indicator of judging the prognosis of osteosarcoma. PMID: 32457395
Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation. PMID: 31519860
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. PMID: 30062819
Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells. PMID: 28475463
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia. PMID: 28625463
Immune Diseases Associated with TREX1 and STING Dysfunction. PMID: 26377892
TREX1 Cuts Down on Cancer Immunogenicity. PMID: 23578789
Exonuclease TREX1 also Has a Sweet Tooth. PMID: 31932809
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. PMID: 28325644
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. PMID: 34400195
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. PMID: 35086391
Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. PMID: 28886359
Genetic screening of early-onset patients with systemic lupus erythematosus by a targeted next-generation sequencing gene panel. PMID: 29769349
The TREX1 Dinosaur Bites the Brain through the LINE. PMID: 21937424
HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. PMID: 17293595
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity. PMID: 32565148
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. PMID: 36745566
Celastrol ameliorates autoimmune disorders in Trex1-deficient mice. PMID: 35357486
TREX1 cytosolic DNA degradation correlates with autoimmune disease and cancer immunity. PMID: 32719516
TREX1 degrades the 3' end of the small DNA oligonucleotide products of nucleotide excision repair in human cells. PMID: 30872080
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. PMID: 34813765
cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model. PMID: 35112355
TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion. PMID: 27525044
Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells. PMID: 29100097
Restricting retrotransposons: a review. PMID: 18045533
Monogenic lupus: it's all new! PMID: 27511730
Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease., PMID:40476824
Expanding the spectrum of genetic causes of DNA-specific exonuclease TREX1 variants in thrombotic microangiopathy., PMID:40383229
Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1-/- mice., PMID:40319749
The induction of type I interferonopathy in Trex1-P212fs mice is mediated by activation of the cGAS-STING pathway., PMID:40268028
Tanshinone IIA alleviates myocarditis in Trex1-D18N lupus-like mice by inhibiting the interaction between STING and SEC24C., PMID:40252465
High Tumor Mutation Burden (TMB) and a Novel Somatic Mutation in the TREX1 Gene in a Patient with Aggressive and Refractory High-Grade B-Cell Lymphoma: A Case Report., PMID:40243506
A Metformin-Based Multifunctional Nanoplatform as a DNA Damage Amplifier for Maximized Radio-Immunotherapy to Overcome Radiotherapy Resistance., PMID:40207668
Discovery of Potent STING Inhibitors Bearing a Difluorobenzodioxol Structural Motif as Potent Anti-Inflammatory Agents., PMID:40188441
Exome sequencing of a Portuguese cohort of early-onset Alzheimer's disease implicates the X-linked lysosomal gene GLA., PMID:40185916
212Bi-Macroaggregated Albumin Inhibited Mouse Melanoma Growth by Regulating Cell Cycle Checkpoint Markers Without Promoting Living Cell Repopulation., PMID:40180566
The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis., PMID:40072623
Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome., PMID:40061936
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics., PMID:39999142
Effect of methyl DNA adducts on 3'-5' exonuclease activity of human TREX1., PMID:39998308
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases., PMID:39965124
SESN1 negatively regulates STING1 to maintain innate immune homeostasis., PMID:39945079
Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation., PMID:39875322
Cobalt chloride-mimicked hepatocyte cell hypoxia induces TREX1 leading to Hepatitis B virus restriction., PMID:39761821
Cordycepin ameliorates autoimmunity by promoting STING degradation via autophagy pathway., PMID:39675775
Prime Editor Gene Therapy and TREX1 Mosaicism in Retinal Vasculopathy with Cerebral Leukoencephalopathy., PMID:39671052
Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma., PMID:39658648
The SLE-associated TREX1-P212fs mutation disrupts ER association leading to type I interferonopathy., PMID:39621297
Single-stranded DNA with internal base modifications mediates highly efficient knock-in in primary cells using CRISPR-Cas9., PMID:39569586
Ginkgetin Alleviates Inflammation and Senescence by Targeting STING., PMID:39558862
Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks., PMID:39487167
Discovery and Total Synthesis of Anhydrotuberosin as a STING Antagonist for Treating Autoimmune Diseases., PMID:39471366
An overview of genetic mutations in Aicardi-Goutières syndrome in Iranian population., PMID:39470906
The highly conserved region within exonuclease III-like in PML-I regulates the cytoplasmic localization of PML-NBs., PMID:39395810
Systemic complications of Aicardi Goutières syndrome using real-world data., PMID:39332260
[SUV3 knockdown inhibits proliferation, migration, and invasion of hepatocellular carcinoma cells and induces PD-L1 expression]., PMID:39267568
cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice., PMID:39254994
Proteomics Analysis of Renal Cell Line Caki-2 with AFMID Overexpression and Potential Biomarker Discovery in Urine., PMID:39213636
Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases., PMID:39190126
Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response., PMID:39180588
A novel TREX1 inhibitor, VB-85680, upregulates cellular interferon responses., PMID:39178223
Targeting TREX1 Induces Innate Immune Response in Drug-Resistant Small-Cell Lung Cancer., PMID:39177280
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding., PMID:39148120
R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells., PMID:39120648
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations in conjunction with systemic lupus erythematosus: Missed diagnosis or misdiagnosis?, PMID:39119967
The activation of cGAS-STING pathway causes abnormal uterine receptivity in aged mice., PMID:39113346
Retinal vasculopathy with cerebral leukoencephalopathy: a rare mimic of CNS vasculitis., PMID:39084908
Cyclopeptide Inhibitors Target the N-Terminal Tail of STING and Alleviate Autoinflammation., PMID:38997793
STING trafficking activates MAPK-CREB signaling to trigger regulatory T cell differentiation., PMID:38985760
Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair., PMID:38982049
Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining., PMID:38963141
Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study., PMID:38950286
The cGAS-STING pathway drives inflammation in Usual Interstitial Pneumonia, phagocytosis could prevent inflammation but is inhibited by the don't eat me signal CD47., PMID:38944022
MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling., PMID:38926338
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection., PMID:38917796
Identification of the cytoplasmic DNA-Sensing cGAS-STING pathway-mediated gene signatures and molecular subtypes in prostate cancer., PMID:38877472
For research use only. Not for human or drug use.
