Catalog No.
YHJ67502
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met11-His222
Predicted molecular weight
35.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NSU2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
TREX1, Deoxyribonuclease III, DNase III, Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1
Genetics, TREX1 Mutations. PMID: 31335009
TREX1 plays multiple roles in human diseases. PMID: 35468328
ER-directed TREX1 limits cGAS activation at micronuclei. PMID: 33476576
The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. PMID: 35127372
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. PMID: 28598415
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion. PMID: 34551315
TREX1 as a Novel Immunotherapeutic Target. PMID: 33868310
Trex1 prevents cell-intrinsic initiation of autoimmunity. PMID: 18724932
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. PMID: 33606975
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy. PMID: 34382907
Aicardi-Goutières Syndrome. PMID: 20301648
Structural basis of human TREX1 DNA degradation and autoimmune disease. PMID: 35879334
STING inhibitors target the cyclic dinucleotide binding pocket. PMID: 34099558
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. PMID: 36070769
The abscopal effect of radiation therapy. PMID: 33726502
p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression. PMID: 36638783
Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1. PMID: 35403787
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation. PMID: 31874111
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. PMID: 29907693
Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. PMID: 23962476
The interferon response to intracellular DNA: why so many receptors? PMID: 35349719
Human TDP1, APE1 and TREX1 repair 3'-DNA-peptide/protein cross-links arising from abasic sites in vitro. PMID: 34997539
TREX1 Deficiency Induces ER Stress-Mediated Neuronal Cell Death by Disrupting Ca2+ Homeostasis. PMID: 30799039
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. PMID: 21478870
A diverse range of gene products are effectors of the type I interferon antiviral response. PMID: 33854495
cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE. PMID: 35239517
Occlusive retinal vasculitis: novel insights into causes, pathogenesis and treatment. PMID: 36217001
The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. PMID: 29593264
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. PMID: 35973990
Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes. PMID: 28334850
Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion. PMID: 24183309
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. PMID: 31475890
TREX1 As a Potential Therapeutic Target for Autoimmune and Inflammatory Diseases. PMID: 26371324
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. PMID: 31455522
Measuring TREX1 and TREX2 exonuclease activities. PMID: 20301334
Hereditary Dystonia Overview. PMID: 33006365
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma. PMID: 28297665
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex. PMID: 25855793
Clinical and molecular phenotype of Aicardi-Goutieres syndrome. PMID: 32615442
Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA. PMID: 27812953
TREX1 - Apex predator of cytosolic DNA metabolism. PMID: 23979357
Monogenic Lupus. PMID: 36696898
The TREX1 C-terminal region controls cellular localization through ubiquitination. PMID: 31326279
Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks. PMID: 25848017
TREX1 variants in Sjogren's syndrome related lymphomagenesis. PMID: 35699195
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. PMID: 29941221
Systematic Review of Cerebral Phenotypes Associated With Monogenic Cerebral Small-Vessel Disease. PMID: 23622384
TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation. PMID: 25731743
Aicardi-Goutières syndrome. PMID: 33823133
Human disease phenotypes associated with mutations in TREX1. PMID: 27881153
The spatial organization of cGAS-TREX1 interactions. PMID: 33892200
Verification of TREX1 as a promising indicator of judging the prognosis of osteosarcoma. PMID: 32457395
Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation. PMID: 31519860
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. PMID: 30062819
Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells. PMID: 28475463
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia. PMID: 28625463
Immune Diseases Associated with TREX1 and STING Dysfunction. PMID: 26377892
TREX1 Cuts Down on Cancer Immunogenicity. PMID: 23578789
Exonuclease TREX1 also Has a Sweet Tooth. PMID: 31932809
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. PMID: 28325644
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. PMID: 34400195
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. PMID: 35086391
Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. PMID: 28886359
Genetic screening of early-onset patients with systemic lupus erythematosus by a targeted next-generation sequencing gene panel. PMID: 29769349
The TREX1 Dinosaur Bites the Brain through the LINE. PMID: 21937424
HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. PMID: 17293595
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity. PMID: 32565148
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. PMID: 36745566
Celastrol ameliorates autoimmune disorders in Trex1-deficient mice. PMID: 35357486
TREX1 cytosolic DNA degradation correlates with autoimmune disease and cancer immunity. PMID: 32719516
TREX1 degrades the 3' end of the small DNA oligonucleotide products of nucleotide excision repair in human cells. PMID: 30872080
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. PMID: 34813765
cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model. PMID: 35112355
TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion. PMID: 27525044
Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells. PMID: 29100097
Restricting retrotransposons: a review. PMID: 18045533
Monogenic lupus: it's all new! PMID: 27511730
For research use only. Not for human or drug use.
