The G Protein-Coupled Receptor GPR17: Overview and Update. PMID: 27863043
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion. PMID: 34986353
Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein. PMID: 36105372
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. PMID: 33108748
G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models. PMID: 29873041
G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. PMID: 34120140
Orphan G protein-coupled receptors: The role in CNS disorders. PMID: 29268243
Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence. PMID: 36613703
Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis. PMID: 33309882
G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination. PMID: 29540737
Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination. PMID: 27733608
GPR17 plays a role in ischemia-induced endogenous repair of immature neonatal cerebral White matter. PMID: 32387084
Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles. PMID: 34144038
SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation. PMID: 27270750
The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. PMID: 26620557
GPR17 receptor modulators and their therapeutic implications: review of recent patents. PMID: 30640576
GPR17 mediates ischemia-like neuronal injury via microglial activation. PMID: 30226562
Regulation and signaling of the GPR17 receptor in oligodendroglial cells. PMID: 32086854
A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. PMID: 30865888
Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL). PMID: 34569901
Targeting Orphan G Protein-Coupled Receptor 17 with T0 Ligand Impairs Glioblastoma Growth. PMID: 34359676
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. PMID: 19838178
Involvement of GPR17 in Neuronal Fibre Outgrowth. PMID: 34769111
Identification of novel GPR17-agonists by structural bioinformatics and signaling activation. PMID: 28827203
G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis. PMID: 34979406
Expression of cysteinyl leukotriene receptor GPR17 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. PMID: 29161055
The GPR17 Receptor-A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis. PMID: 32182666
Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17). PMID: 28223679
[G protein-coupled receptor 17 is involved in CoCl2-induced hypoxic injury in RGC-5 cells]. PMID: 30693690
Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification. PMID: 36716660
Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication. PMID: 33140689
Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine. PMID: 28828731
Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation. PMID: 29706593
CRNDE/ETS1/GPR17 Facilitates the Proliferation, Migration, and Invasion of Glioma. PMID: 34853603
GPR17 gene disruption does not alter food intake or glucose homeostasis in mice. PMID: 25624481
The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients. PMID: 33925469
Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin. PMID: 26180086
GPR17 is an essential regulator for the temporal adaptation of sonic hedgehog signalling in neural tube development. PMID: 31444216
Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination. PMID: 31998697
The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. PMID: 26228571
Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. PMID: 31727469
GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury. PMID: 26464068
Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice. PMID: 32244295
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin. PMID: 34646232
Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. PMID: 24150254
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PMID: 18974869
The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells. PMID: 23288840
Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells. PMID: 35163437
Cangrelor alleviates pulmonary fibrosis by inhibiting GPR17-mediated inflammation in mice. PMID: 30036769
Development of an immobilized GPR17 receptor stationary phase for binding determination using frontal affinity chromatography coupled to mass spectrometry. PMID: 18835238
Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding. PMID: 31611548
Identification and characterization of select oxysterols as ligands for GPR17. PMID: 36214386
The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. PMID: 19528093
Expression of GPR17, a regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains. PMID: 28357182
Inhibition of GPR17 with pranlukast protects against TNF-α-induced loss of type II collagen in ATDC5 cells. PMID: 32805694
Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. PMID: 21209081
The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes. PMID: 28254957
Structural analysis of human G-protein-coupled receptor 17 ligand binding sites. PMID: 36791278
Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17. PMID: 20056144
Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death. PMID: 21264945
GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. PMID: 19561298
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights. PMID: 26971834
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs. PMID: 36126653
The GPR17 receptor in NG2 expressing cells: focus on in vivo cell maturation and participation in acute trauma and chronic damage. PMID: 21956849
Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. PMID: 21531793
Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17. PMID: 21773766
GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. PMID: 18533035
Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. PMID: 20233425
The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review. PMID: 30904492
Analysis of the GPR17 receptor in NG2-glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions. PMID: 36815579
Zhenbao pill protects against acute spinal cord injury via miR-146a-5p regulating the expression of GPR17. PMID: 29187582
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. PMID: 30048589
Mitochondrial complex III bypass complex I to induce ROS in GPR17 signaling activation in GBM. PMID: 37054539
EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. PMID: 21261596
Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury. PMID: 23801362
Expression of dual nucleotides/cysteinyl-leukotrienes receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. PMID: 24909956
[Role of G protein-coupled receptor 17 in central nervous system injury]. PMID: 23801627
A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro. PMID: 27544384
Molecular modeling and dynamics studies of the synthetic small molecule agonists with GPR17 and P2Y1 receptor. PMID: 34542380
Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. PMID: 20394377
The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats. PMID: 22155652
Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells. PMID: 35954217
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. PMID: 22682251
Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination. PMID: 29424466
GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma. PMID: 35016881
Cangrelor ameliorates CLP-induced pulmonary injury in sepsis by inhibiting GPR17. PMID: 34229761
Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. PMID: 23908386
Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment. PMID: 34304559
Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. PMID: 19625605
UDP-glucose enhances outward K(+) currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors. PMID: 23640798
The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke. PMID: 28594400
Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors. PMID: 28289782
CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17. PMID: 26453964
Commentary on 'Identification and characterization of select oxysterols as ligands for GPR17'. PMID: 36669769
[Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice]. PMID: 23505108
Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1-42 through Nrf2/HO-1 and NF-κB signaling pathway in mice. PMID: 34781121
GPR17 regulates immune pulmonary inflammation induced by house dust mites. PMID: 20574000
Enigmatic GPCR finds a stimulating drug. PMID: 24150253
Fishing for a balance: Toward promyelinating drug discovery. PMID: 36270232
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs. PMID: 33202251
Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. PMID: 34440745
[Recently identified GPR17 receptors--characteristics and role in pathology of the nervous system]. PMID: 25807830
Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes. PMID: 36565228
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