Catalog No.
YHG59502
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly411-Lys624
Predicted molecular weight
36.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13574
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DAGK6, DAG kinase zeta, Diglyceride kinase zeta, DGK-zeta, Diacylglycerol kinase zeta, DGKZ
DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2. PMID: 35115500
Expression analysis and genotyping of DGKZ: a GWAS-derived risk gene for schizophrenia. PMID: 31087244
DGKZ Acts as a Potential Oncogene in Osteosarcoma Proliferation Through Its Possible Interaction With ERK1/2 and MYC Pathway. PMID: 30662872
Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development. PMID: 33887567
Knockdown of diacylglycerol kinase zeta (DGKZ) induces apoptosis and G2/M phase arrest in human acute myeloid leukemia HL-60 cells through MAPK/survivin/caspase pathway. PMID: 31288898
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest. PMID: 33926342
Diacylglycerol kinases in cancer. PMID: 27697466
Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. PMID: 36232920
Tyrosinase: a central regulatory protein for cutaneous pigmentation. PMID: 23187110
Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS. PMID: 32549284
Reciprocal regulation of p53 and NF-κB by diacylglycerol kinase ζ. PMID: 26521214
Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners. PMID: 33450306
The effect of HMGB1 on the clinicopathological and prognostic features of non-small cell lung cancer. PMID: 26840258
DzMab-1: Anti-Human Diacylglycerol Kinaseζ Monoclonal Antibody for Immunocytochemistry. PMID: 31403910
Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions. PMID: 25921290
Identification of target genes in neuroinflammation and neurodegeneration after traumatic brain injury in rats. PMID: 31875163
Diacylglycerol kinase regulation of protein kinase D during oxidative stress-induced intestinal cell injury. PMID: 18694729
Analytical Method for Diacylglycerol Kinase ζ Activity in Cells Using Protein Myristoylation and Liquid Chromatography-Tandem Mass Spectrometry. PMID: 31736090
African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. PMID: 27269905
Endocannabinoids and diacylglycerol kinase activity. PMID: 21194521
Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review. PMID: 29910734
p53 induces distinct epigenetic states at its direct target promoters. PMID: 18922183
Negative feedback regulation of Gq signaling by protein kinase C is disrupted by diacylglycerol kinase ζ in COS-7 cells. PMID: 22197823
Epitope Mapping of Anti-Diacylglycerol Kinase Zeta Monoclonal Antibody DzMab-1 for Immunohistochemical Analyses. PMID: 31355694
DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy. PMID: 24937670
Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor. PMID: 31722116
DGKζ Plays Crucial Roles in the Proliferation and Tumorigenicity of Human glioblastoma. PMID: 31523189
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. PMID: 31481522
Integrated genomic profiling identifies loss of chromosome 11p impacting transcriptomic activity in aggressive pituitary PRL tumors. PMID: 21251114
SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes. PMID: 29180720
RNA sequencing identifies upregulated kyphoscoliosis peptidase and phosphatidic acid signaling pathways in muscle hypertrophy generated by transgenic expression of myostatin propeptide. PMID: 25860951
Is there a role for diacylglycerol kinase-zeta in cell cycle regulation? PMID: 18358241
Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway. PMID: 25450975
Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia. PMID: 24958494
Epitope Mapping of Anti-Diacylglycerol Kinase ζ Monoclonal Antibody for the Detection of T Cells by Immunohistochemical Analyses. PMID: 31112065
Dysregulated miR34a/diacylglycerol kinase ζ interaction enhances T-cell activation in acquired aplastic anemia. PMID: 28008152
Loss of Diacylglycerol Kinase-Ζ Inhibits Cell Proliferation and Survival in Human Gliomas. PMID: 26452358
Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse. PMID: 21937721
Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes. PMID: 22895365
Translocation dynamics of sorting nexin 27 in activated T cells. PMID: 21303929
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. PMID: 19229292
Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. PMID: 23723068
The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample. PMID: 19308020
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase. PMID: 18004883
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. PMID: 19211846
Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells. PMID: 27999176
Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins. PMID: 21996351
Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2. PMID: 31626956
Increased diacylglycerol kinase ζ expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion. PMID: 24646293
For research use only. Not for human or drug use.
