Catalog No.
YHJ79002
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys204-Asn397
Predicted molecular weight
24.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKQ2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MDCL, MDC-L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, ADAM 28, ADAM28, eMDC II, ADAM23, Disintegrin and metalloproteinase domain-containing protein 28
Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer. PMID: 31602160
CD20+CD22+ADAM28+ B Cells in Tertiary Lymphoid Structures Promote Immunotherapy Response. PMID: 35634306
ADAM28: Another ambivalent protease in cancer. PMID: 32861707
ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death. PMID: 26918856
ADAM28 dramatically regulates the biological features of human gingival fibroblasts. PMID: 30552542
ADAM28 localizes to HLA-G+ trophoblasts and promotes column cell outgrowth. PMID: 28623976
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice. PMID: 28430139
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. PMID: 22636800
ADAM28 as a target for human cancers. PMID: 19601836
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. PMID: 32499443
Catalytic activity of ADAM28. PMID: 11389903
ADAM28 from both endothelium and gastric cancer cleaves von Willebrand Factor to eliminate von Willebrand Factor-induced apoptosis of gastric cancer cells. PMID: 33675784
ADAM28 promotes tumor growth and dissemination of acute myeloid leukemia through IGFBP-3 degradation and IGF-I-induced cell proliferation. PMID: 30429106
ADAM28 manipulates proliferation, differentiation, and apoptosis of human dental pulp stem cells. PMID: 21329817
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-α. PMID: 23010875
ADAM28 participates in the regulation of tooth development. PMID: 16836973
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers. PMID: 20112342
[Research advances on ADAM28 expression and ADAM28-mediated tumor metastasis]. PMID: 25130845
Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration. PMID: 21332445
Influence of ADAM28 on biological characteristics of human dental follicle cells. PMID: 19580958
Urinary protein profiling by liquid chromatography/tandem mass spectrometry: ADAM28 is overexpressed in bladder transitional cell carcinoma. PMID: 21913264
Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells. PMID: 24007880
LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. PMID: 36054559
Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging. PMID: 35211476
CircRNA_100565 contributes to cisplatin resistance of NSCLC cells by regulating proliferation, apoptosis and autophagy via miR-337-3p/ADAM28 axis. PMID: 33682697
Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression. PMID: 23643150
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. PMID: 22354764
ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. PMID: 15013428
Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28. PMID: 10794709
[Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. PMID: 33543212
Connective tissue growth factor is a substrate of ADAM28. PMID: 20971063
ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. PMID: 17047053
New wrinkle between cancer and blood coagulation: metastasis and cleavage of von Willebrand factor by ADAM28. PMID: 22636799
ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas. PMID: 20544843
Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer. PMID: 27749584
Essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells (hDPMCs). PMID: 18690470
[Effects of ADAM28 on biological functions of human dental pulp stem cells]. PMID: 20635038
ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. PMID: 16052521
The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia. PMID: 25453333
[The construction of ADAM28 eukaryotic expression plasmid and expression after transfected into HDFC]. PMID: 17924028
Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis. PMID: 30190423
MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway. PMID: 30840270
The regulatory role of a disintegrin and metalloproteinase 28 on the biologic property of human periodontal ligament stem cells. PMID: 20450360
Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis. PMID: 21782798
[Effects of ADAM28 AS-ODN on proliferation and AKPase of HDFCs]. PMID: 16685358
Expression of ADAM28 and IGFBP-3 genes in patients with colorectal cancer - a preliminary report. PMID: 23527725
Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells. PMID: 17597069
Correction: ADAM28 Is Overexpressed in Human Breast Carcinomas: Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3. PMID: 26471916
Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients. PMID: 29254295
[Effects of ADAM28 AS-ODN on proliferation, differentiation and apoptosis of HPDLSC]. PMID: 19907862
The origin and diversification of a novel protein family in venomous snakes. PMID: 32366667
CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells. PMID: 28707394
Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B. PMID: 30135119
All-trans retinoic acid-induced ADAM28 degrades proteoglycans in human chondrocytes. PMID: 19527685
Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28. PMID: 15883027
ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer. PMID: 23810013
Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. PMID: 23132922
[ADAM28: involvement in cancer cell proliferation, invasion and metastasis]. PMID: 21077327
Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1. PMID: 30352365
Characterization of CD200 Ectodomain Shedding. PMID: 27111430
[The effects of ADAM28 AS-ODN on biological function of human gingival fibroblasts]. PMID: 25543593
Modulation of the microenvironment and adhesion of cancer cells by ADAMs (a disintegrin and metalloproteinase). PMID: 18314593
First draft of the genomic organization of a PIII-SVMP gene. PMID: 22543188
ADAMs in cancer cell proliferation and progression. PMID: 17355265
An ADAM family member with expression in thymic epithelial cells and related tissues. PMID: 11867223
Effects of AIF-1 inflammatory factors on the regulation of proliferation of breast cancer cells. PMID: 31389223
ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. PMID: 15504110
Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2. PMID: 17268172
Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. PMID: 12777399
Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers. PMID: 22292754
[The effects of ADAM28 on HDPC biological characteristics]. PMID: 18661070
Identification of genes expressed in the migrating primitive myeloid lineage of Xenopus laevis. PMID: 26264370
The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. PMID: 12037602
Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders. PMID: 30759440
Impact of male fertility status on the transcriptome of the bovine epididymis. PMID: 28379507
Whole-genome scan reveals significant non-additive effects for sire conception rate in Holstein cattle. PMID: 29486732
Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results. PMID: 31565100
A proteomic approach for identification and localization of the pericellular components of chondrocytes. PMID: 21698479
ADAM-17 expression is enhanced by FoxM1 and is a poor prognostic sign in gastric carcinoma. PMID: 29180185
Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis. PMID: 36368116
Imatinib reduces cholesterol uptake and matrix metalloproteinase activity in human THP-1 macrophages. PMID: 26721343
MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28. PMID: 27661126
Insights into the Evolution of a Snake Venom Multi-Gene Family from the Genomic Organization of Echis ocellatus SVMP Genes. PMID: 27420095
IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells. PMID: 24613731
Conservation and divergence of ADAM family proteins in the Xenopus genome. PMID: 20630080
MS4A1 dysregulation in asbestos-related lung squamous cell carcinoma is due to CD20 stromal lymphocyte expression. PMID: 22514692
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma. PMID: 19896699
Downregulation of integrin receptor-signaling genes by Epstein-Barr virus EBNA 3C via promoter-proximal and -distal binding elements. PMID: 22357270
The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1. PMID: 11724793
EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells. PMID: 26751214
Integrin alpha4beta1-dependent adhesion to ADAM 28 (MDC-L) requires an extended surface of the disintegrin domain. PMID: 12667064
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming. PMID: 24068937
Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. PMID: 14719095
Localization of the gene for hyperostosis cranialis interna to chromosome 8p21 with analysis of three candidate genes. PMID: 23640157
Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis. PMID: 10587367
Gene expression profile of ADAMs and ADAMTSs metalloproteinases in normal and malignant plasma cells and in the bone marrow environment. PMID: 21316416
For research use only. Not for human or drug use.
