Catalog No.
YHC85003
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly70-Lys287
Predicted molecular weight
26.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11047
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Laminin-7 subunit gamma, Laminin-1 subunit gamma, Laminin subunit gamma-1, Laminin-10 subunit gamma, Laminin-2 subunit gamma, S-laminin subunit gamma, LAMC1, Laminin-11 subunit gamma, Laminin-3 subunit gamma, S-LAM gamma, Laminin-6 subunit gamma, Laminin-9 subunit gamma, Laminin-4 subunit gamma, Laminin-8 subunit gamma, LAMB2, Laminin B2 chain, laminin 1, laminin 111, EHS laminin, laminin 2, laminin 211, merosin, laminin 3, laminin 121, S laminin, laminin 4, laminin 221, S merosin, laminin 6, laminin 311, K laminin, laminin 7, laminin 321, KS laminin, laminin 8, laminin 411, laminin 9, laminin 421, laminin 10, laminin 511, laminin 11, laminin 521
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis. PMID: 35541892
The laminin family. PMID: 23263632
High LAMC1 expression in glioma is associated with poor prognosis. PMID: 31213842
LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3. PMID: 34218518
LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer. PMID: 31912669
Comprehensive analysis of LAMC1 expression and prognostic value in kidney renal papillary cell carcinoma and clear cell carcinoma. PMID: 36188228
Overexpression of LAMC1 predicts poor prognosis and enhances tumor cell invasion and migration in hepatocellular carcinoma. PMID: 28928891
LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies. PMID: 33884884
Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway. PMID: 30755064
LAMC1 mRNA promotes malignancy of hepatocellular carcinoma cells by competing for MicroRNA-124 binding with CD151. PMID: 28524360
Anti-p200 pemphigoid. PMID: 24767733
MicroRNA-506 Inhibits Malignancy of Colorectal Carcinoma Cells by Targeting LAMC1. PMID: 27993882
Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population. PMID: 32635941
MicroRNA-29b Overexpression Decreases Extracellular Matrix mRNA and Protein Production in Human Corneal Endothelial Cells. PMID: 27490049
The long non-coding RNA ASMTL-AS1 promotes hepatocellular carcinoma progression by sponging miR-1343-3p that suppresses LAMC1 (laminin subunit gamma 1). PMID: 34859735
Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux. PMID: 36417404
LAMC1 gene is associated with premature ovarian failure. PMID: 22321639
Polymorphisms in DLGH1 and LAMC1 in Mayer-Rokitansky-Kuster-Hauser syndrome. PMID: 22377151
LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression. PMID: 36411963
Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity. PMID: 35373932
The Intriguing Links between Psoriasis and Bullous Pemphigoid. PMID: 36615129
Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles. PMID: 23674478
Anti-laminin γ1 pemphigoid. PMID: 23480370
Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. PMID: 22342894
Anti-p200 Pemphigoid: A Systematic Review. PMID: 31695695
Anti-laminin gamma-1 pemphigoid. PMID: 19196964
IgA anti-p200 pemphigoid. PMID: 22106117
Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B. PMID: 35031421
PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1. PMID: 35022330
Structural mechanism of laminin recognition by integrin. PMID: 34188035
Autoimmune blistering dermatoses as systemic diseases. PMID: 24767184
The targeted deletion of the LAMC1 gene. PMID: 9917858
Nodular formation in anti-laminin γ1 pemphigoid. PMID: 31916269
Pathogenicity of autoantibodies in anti-p200 pemphigoid. PMID: 22911854
Circular ribonucleic acid nei-like deoxyribonucleic acid glycosylase 3 governs the microribonucleic acid -3150b-3p/laminin subunit gamma 1 network to partially promote the development of hepatocellular carcinoma. PMID: 33738908
Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. PMID: 20167606
miR-506 contributes to malignancy of cutaneous squamous cell carcinoma via targeting of P65 and LAMC1. PMID: 30646812
From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid. PMID: 20507386
miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. PMID: 26052614
Serological investigation of bullous scabies and review of the published work. PMID: 30969443
Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer. PMID: 24820027
Psoriasis and basement-membrane laminin. PMID: 23607274
Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. PMID: 17021862
Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular carcinomas. PMID: 9403717
Fukutin-related protein alters the deposition of laminin in the eye and brain. PMID: 21900571
Amino acid residues in the laminin G domains of protein S involved in tissue factor pathway inhibitor interaction. PMID: 25716664
Estrogen receptor and laminin genetic polymorphism among women with pelvic organ prolapse. PMID: 29241914
Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? PMID: 20223449
Isolation of a novel gene from the DiGeorge syndrome critical region with homology to Drosophila gdl and to human LAMC1 genes. PMID: 8733130
A case report of anti-P200 pemphigoid following COVID-19 vaccination. PMID: 35308065
Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination. PMID: 28636612
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. PMID: 23266556
Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability. PMID: 19530222
Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survival. PMID: 23132868
Structural and genetic analysis of laminin-nidogen interaction. PMID: 9917838
Junctional epidermolysis bullosa inversa (locus EBR2A) assigned to 1q31 by linkage and association to LAMC1. PMID: 7987320
The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis. PMID: 31848396
Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and Management. PMID: 28779299
Case of anti-p200 pemphigoid accompanying uterine malignancy. PMID: 29766559
A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study. PMID: 34596730
Laminin is the ECM niche for trophoblast stem cells. PMID: 31937556
The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells. PMID: 30160193
A functional polymorphism located at transcription factor binding sites, rs6695837 near LAMC1 gene, confers risk of colorectal cancer in Chinese populations. PMID: 28039327
Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. PMID: 27234308
Diagnosis of anti-laminin γ-1 pemphigoid by immunoblot analysis. PMID: 29972879
Impaired wound healing in mice lacking the basement membrane protein nidogen 1. PMID: 19766719
Refractory Pemphigoid with Autoantibodies to Both BP230 and Laminin gamma1. PMID: 31449311
Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. PMID: 9885251
Serologic characterization of anti-p200 pemphigoid: Epitope spreading as a common phenomenon. PMID: 32711089
Role of laminin-nidogen complexes in basement membrane formation during embryonic development. PMID: 7556571
Transcription factor CCAAT enhancer-binding protein beta (C/EBPbeta) regulates the formation of a unique extracellular matrix that controls uterine stromal differentiation and embryo implantation. PMID: 21471197
When Bullous Pemphigoid Is Not Bullous Pemphigoid: The Importance of Going Beyond Direct Immunofluorescence. PMID: 35308677
Spatiotemporal expression profiling of proteins in rat sciatic nerve regeneration using reverse phase protein arrays. PMID: 22325251
Abnormal Endothelial Gene Expression Associated With Early Coronary Atherosclerosis. PMID: 32673514
A two-step immunoblot assay for serological diagnosis of anti-laminin γ-1 pemphigoid. PMID: 30924244
Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. PMID: 19193855
Transcription of laminin gamma1 chain gene in rat mesangial cells: constitutive and inducible RNA polymerase II recruitment and chromatin states. PMID: 18184742
Anopheles gambiae laminin interacts with the P25 surface protein of Plasmodium berghei ookinetes. PMID: 11223130
Laminin-γ1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons. PMID: 23145988
Effects of long-term immobilisation on endomysium of the soleus muscle in humans. PMID: 34387385
Plasma from cancer patients featuring a characteristic protein composition mediates protection against apoptosis. PMID: 12118080
Neuropathology of primary adult-onset dystonia. PMID: 18299520
Dual role of laminin‑511 in regulating melanocyte migration and differentiation. PMID: 30273664
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori. PMID: 16401634
Expression of laminin gamma 1 cultured hepatocytes involves repeated CTC and GC elements in the LAMC1 promoter. PMID: 8611150
Anti-p200/laminin γ1 pemphigoid associated with metastatic oesophageal cancer. PMID: 27684497
Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules. PMID: 16529943
Refractory bullous pemphigoid with IgE anti-BP230 and IgG anti-p200 antibodies successfully treated with omalizumab. PMID: 33478824
A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease. PMID: 30273365
Correlation of extracellular matrix-related gene expression with objective Fuchs endothelial corneal dystrophy severity. PMID: 30578652
Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering. PMID: 30451239
bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins. PMID: 11801598
Podocyte-specific expression of Cre recombinase promotes glomerular basement membrane thickening. PMID: 30810063
Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain. PMID: 20876210
A case of paraneoplastic pemphigus associated with Castleman disease reacting with multiple autoantigens, including the p200 protein. PMID: 27115591
Laboratory Diagnosis and Clinical Profile of Anti-p200 Pemphigoid. PMID: 27167149
Ex vivo pathogenicity of anti-laminin γ1 autoantibodies. PMID: 24300951
Atypical anti-p200 pemphigoid with nail involvement and blisters over the joints. PMID: 31846162
Clinical and immunological features and outcome of anti-p200 pemphigoid. PMID: 27037896
Erythromegakaryocytic cells synthesize laminin-8 (alpha4beta1gamma1). PMID: 10623479
Laminin C1 expression by uterine carcinoma cells is associated with tumor progression. PMID: 26343160
The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. PMID: 27176932
Treatment of anti-laminin γ1 pemphigoid with mycophenolate mofetil. PMID: 26058852
Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5. PMID: 16672690
Transcriptome analyses reveal differentially expressed genes associated with development of the palatal organ in bighead carp (Hypophthalmichthys nobilis). PMID: 36990038
The Anopheles gambiae gamma1 laminin directly binds the Plasmodium berghei circumsporozoite- and TRAP-related protein (CTRP). PMID: 15694493
Anti-laminin γ1 pemphigoid associated with pustular psoriasis. PMID: 25075951
For research use only. Not for human or drug use.
