Dynamin 2 (DNM2) as Cause of, and Modifier for, Human Neuromuscular Disease. PMID: 30426359
BIN1 modulation in vivo rescues dynamin-related myopathy. PMID: 35217605
Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. PMID: 35777482
Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy. PMID: 30291191
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation. PMID: 34190023
Tamoxifen improves muscle structure and function of Bin1- and Dnm2-related centronuclear myopathies. PMID: 36562127
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. PMID: 27885263
Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice. PMID: 28589938
DNM2 mutations in Chinese Han patients with centronuclear myopathy. PMID: 26908122
Imaging-based evaluation of pathogenicity by novel DNM2 variants associated with centronuclear myopathy. PMID: 34837441
Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct. PMID: 26791826
The myopathy-causing mutation DNM2-S619L leads to defective tubulation in vitro and in developing zebrafish. PMID: 24135484
A well-oiled machine: DNM2/dynamin 2 helps keep hepatocyte lipophagy running smoothly. PMID: 24351653
Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. PMID: 33050207
Scission, a critical step in autophagosome formation. PMID: 32544363
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. PMID: 23975875
A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target. PMID: 34294140
Regulation of endothelial nitric oxide synthase activity by protein-protein interaction. PMID: 24180383
Neuromuscular junction abnormalities in DNM2-related centronuclear myopathy. PMID: 23338057
Implication of Dynamin-2 (DNM2) Mutations in Adult T-cell Acute Lymphoblastic Leukemia. PMID: 37116148
Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice. PMID: 29506908
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy. PMID: 32315611
Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations. PMID: 21221624
A new mutation in DNM2 gene in a large Italian family. PMID: 33459893
A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy. PMID: 28366933
mir-204-5p Acts as a Tumor Suppressor by Targeting DNM2 in Osteosarcoma Cells. PMID: 35186244
Myotonia in DNM2-related centronuclear myopathy. PMID: 24366529
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model. PMID: 35763354
A dog model for centronuclear myopathy carrying the most common DNM2 mutation. PMID: 35244154
Satellite cells deficiency and defective regeneration in dynamin 2-related centronuclear myopathy. PMID: 33715228
Some DNM2 mutations cause extremely severe congenital myopathy and phenocopy myotubular myopathy. PMID: 30208955
Dynamin 2 and human diseases. PMID: 20127478
Insights into wild-type dynamin 2 and the consequences of DNM2 mutations from transgenic zebrafish. PMID: 31691805
Protein partners of dynamin-1 in the retina. PMID: 23746204
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes. PMID: 37139790
Development of Research into Autophagic Lysosome Reformation. PMID: 29370688
Congenital myopathies: an update. PMID: 22392505
RNA-targeted drugs for neuromuscular diseases. PMID: 33384365
Photochemical tissue bonding promotes the proliferation and migration of injured tenocytes through ROS/RhoA/NF-κB/Dynamin 2 signaling pathway. PMID: 29744878
Different in vivo impacts of dynamin 2 mutations implicated in Charcot-Marie-Tooth neuropathy or centronuclear myopathy. PMID: 31628461
Two dynamin-2 genes are required for normal zebrafish development. PMID: 23418470
Sporadic centronuclear myopathy with muscle pseudohypertrophy, neutropenia, and necklace fibers due to a DNM2 mutation. PMID: 20817456
Centronuclear Myopathy Caused by Defective Membrane Remodelling of Dynamin 2 and BIN1 Variants. PMID: 35682949
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease. PMID: 16775378
Dynamin 2 in Charcot-Marie-Tooth disease. PMID: 22729098
A novel mutation in the DNM2 gene impairs dynamin 2 localization in skeletal muscle of a patient with late onset centronuclear myopathy. PMID: 23374900
Tissue-specific alternative splicing remodels protein-protein interaction networks. PMID: 22749401
Role of dynamin 2 in the disassembly of focal adhesions. PMID: 23609221
Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation. PMID: 29130937
miR-124 attenuates Japanese encephalitis virus replication by targeting DNM2. PMID: 27329300
Zebrafish as a Model to Investigate Dynamin 2-Related Diseases. PMID: 26842864
A location, location, location mutation impairs DNM2-mediated release of nascent autophagosomes from recycling endosomes. PMID: 32453967
Dynamin-2 in nervous system disorders. PMID: 24102355
Overexpression of cytoplasmic dynamin 2 is associated with worse outcomes in patients with clear cell renal cell carcinoma. PMID: 35662107
Muscle imaging in congenital myopathies. PMID: 22172417
Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis. PMID: 23851497
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. PMID: 18236001
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission. PMID: 30531964
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. PMID: 27118408
Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. PMID: 25468568
Dynamin-2 mediates heart failure by modulating Ca2+ -dependent cardiomyocyte apoptosis. PMID: 23410488
Geometric instability catalyzes mitochondrial fission. PMID: 30379601
Mutational and clinical spectrum of centronuclear myopathy in 9 cases and a literature review of Chinese patients. PMID: 34595679
Dynamin 2 Is Correlated with Recurrence and Poor Prognosis of Papillary Thyroid Cancer. PMID: 32827429
ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis. PMID: 30926623
Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells. PMID: 19563849
Centronuclear myopathies: a widening concept. PMID: 20181480
Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function. PMID: 30648534
Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation. PMID: 19932620
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. PMID: 24706848
Dynamin-2 regulates microtubule stability via an endocytosis-independent mechanism. PMID: 36053962
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation. PMID: 28971531
Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes. PMID: 34325130
Paraspinal amyotrophy in DNM-2-related centronuclear myopathy. PMID: 31655408
CAP (Cbl associated protein) regulates receptor-mediated endocytosis. PMID: 19116150
Sporadic centronuclear myopathy with muscle pseudohypertrophy, neutropenia, and necklace fibres due to a DNM2 mutation. PMID: 21247764
Structural insights into the centronuclear myopathy-associated functions of BIN1 and dynamin 2. PMID: 27343996
Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis. PMID: 26542799
A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice. PMID: 20858595
Increased dynamin-1 and -2 protein expression in the aged gerbil hippocampus. PMID: 24752378
Dynamin in disease. PMID: 15731754
Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. PMID: 25092467
Dynamin 2 is essential for mammalian spermatogenesis. PMID: 27725702
Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis. PMID: 19623537
A case of de novo dynamin 2 (DNM2)-related centronuclear myopathy with electrical but not clinical myotonia. PMID: 32826616
Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization. PMID: 36729022
Membrane traffic and muscle: lessons from human disease. PMID: 18266915
Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane. PMID: 26092940
Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy. PMID: 20227276
Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy. PMID: 35293586
Impact of dynamin 2 on adenovirus nuclear entry. PMID: 30660774
Dynamin deficiency causes insulin secretion failure and hyperglycemia. PMID: 34362840
Loss of Dynamin 2 GTPase function results in microcytic anaemia. PMID: 28466468
Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice. PMID: 31296575
Caveosomes and endocytosis of lipid rafts. PMID: 14600257
Dynamin regulates L cell secretion in human gut. PMID: 34274446
Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. PMID: 25088422
The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity. PMID: 21283621
Dynamin Regulates Autophagy by Modulating Lysosomal Function. PMID: 26924690
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin. PMID: 25061227
Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages. PMID: 25347775
Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis. PMID: 26503427
Clinicopathological features of centronuclear myopathy in Japanese populations harboring mutations in dynamin 2. PMID: 22613877
Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model. PMID: 30733559
Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness. PMID: 21514436
The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs. PMID: 26980706
Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome. PMID: 23092955
Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10. PMID: 34349110
The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. PMID: 23994472
Dynamin-2 Regulates Postsynaptic Cytoskeleton Organization and Neuromuscular Junction Development. PMID: 33113375
Clinical, Electrophysiology, and Pathology Features of Dynamin Centronuclear Myopathy: A Case Report and Review of Literature. PMID: 27861221
Increased dynamin expression precedes proteinuria in glomerular disease. PMID: 30350425
Reducing dynamin 2 expression rescues X-linked centronuclear myopathy. PMID: 24569376
For research use only. Not for human or drug use.
