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Recombinant Human MEIS1 Protein, N-His-SUMO

Catalog #:   YHA12902 Specific References (103) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O00470
Protein length: Ser62-Lys180
Overview

Catalog No.

YHA12902

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Ser62-Lys180

Predicted molecular weight

25.64 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O00470

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Homeobox protein Meis1, MEIS1

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human MEIS1 protein
References

Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer. PMID: 35351858

The Historical Relationship Between Meis1 and Leukemia. PMID: 35304708

MEIS1 and its potential as a cancer therapeutic target (Review). PMID: 34318904

Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice. PMID: 30947518

IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. PMID: 35534777

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation. PMID: 34551297

A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. PMID: 32499640

Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc. PMID: 35546301

MEIS1 and Restless Legs Syndrome: A Comprehensive Review. PMID: 31551905

The emerging role of MEIS1 in cell proliferation and differentiation. PMID: 33296285

Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. PMID: 26597775

Homeobox gene Meis1 modulates cardiovascular regeneration. PMID: 31623926

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition. PMID: 32589720

Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis. PMID: 24578510

Emerging Roles of Meis1 in Cardiac Regeneration, Stem Cells and Cancer. PMID: 28745213

HOXA9/MEIS1 targets in leukemia: reinforced signaling networks and therapeutic opportunities. PMID: 36005566

The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice. PMID: 32343715

Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice. PMID: 31229170

Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia. PMID: 26130510

MEIS1 functions as a potential AR negative regulator. PMID: 25158280

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. PMID: 35793392

HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. PMID: 30560549

PREP1, MEIS1 homolog protein, regulates PF4 gene expression. PMID: 12732210

MEIS1 inhibits clear cell renal cell carcinoma cells proliferation and in vitro invasion or migration. PMID: 28270206

Expression of VEGFR-2 and Meis1 in the early stage of kidney cancers and its clinical significance. PMID: 33051419

Study of the dynamic expression of Meis1 in mice. PMID: 24639739

Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. PMID: 9525891

MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma. PMID: 32819319

Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. PMID: 36285442

Probe the relationship between BTBD9 and MEIS1 in C. elegans and mouse. PMID: 34268480

Elucidating the importance and regulation of key enhancers for human MEIS1 expression. PMID: 35624144

Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum. PMID: 35718449

A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer. PMID: 28322463

Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. PMID: 26314854

MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression. PMID: 35947126

Deregulation of the HOXA9/MEIS1 axis in acute leukemia. PMID: 27258906

HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis. PMID: 19620287

MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE-30. PMID: 31090196

Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice. PMID: 35777912

The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. PMID: 15882575

Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation. PMID: 29317485

Meis1: effects on motor phenotypes and the sensorimotor system in mice. PMID: 28645892

MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. PMID: 27018596

MEIS1 regulates early erythroid and megakaryocytic cell fate. PMID: 25107888

Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes. PMID: 30884246

Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response. PMID: 29592525

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. PMID: 23091297

MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. PMID: 25740828

Animal models of RLS phenotypes. PMID: 27839945

Identification of a conserved family of Meis1-related homeobox genes. PMID: 9049632

Restless in the mouse cage-A new genetic model for restless legs syndrome: An Editorial Highlight for "Deficiency of Meis1, a transcriptional regulator, in mice and worms:Neurochemical and behavioral characterizations with implications in the restless legs syndrome" on page 522. PMID: 33011998

Meis1 regulates postnatal cardiomyocyte cell cycle arrest. PMID: 23594737

Platelets take the lead in lymphatic separation. PMID: 20395601

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. PMID: 32681068

Differential transcriptional regulation of meis1 by Gfi1b and its co-factors LSD1 and CoREST. PMID: 23308270

MEIS1 regulated proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension. PMID: 32450174

Sleep disturbance by pramipexole is modified by Meis1 in mice. PMID: 28695622

The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. PMID: 21048033

Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion. PMID: 26986211

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. PMID: 19126776

Deficiency of Meis1, a transcriptional regulator, in mice and worms: Neurochemical and behavioral characterizations with implications in the restless legs syndrome. PMID: 32910473

Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. PMID: 21710629

HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell. PMID: 32197234

Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. PMID: 25013928

c-Met inhibition in a HOXA9/Meis1 model of CN-AML. PMID: 24307265

Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia. PMID: 25911551

Meis1, Hi1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis. PMID: 34496088

The role of Trib1 in myeloid leukaemogenesis and differentiation. PMID: 26517931

[Function of MEIS1 and miR-425 to the Regulating of Chronic Myeloid Leukemia Cell Proliferation]. PMID: 32552939

Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility. PMID: 33145986

Meis1 coordinates a network of genes implicated in eye development and microphthalmia. PMID: 26253404

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1. PMID: 29358086

Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. PMID: 17202314

C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein. PMID: 21900201

MEIS1 Is a Common Transcription Repressor of the miR-23a and NORHA Axis in Granulosa Cells. PMID: 36834999

HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes. PMID: 15494461

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. PMID: 28399410

Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements. PMID: 28054140

Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma. PMID: 27142513

Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. PMID: 21741595

Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma. PMID: 33473327

An unexpected switch: regulation of cardiomyocyte proliferation by the homeobox gene meis1. PMID: 23868827

Pbx1, Meis1, and Runx1 Expression Is Decreased in the Diaphragmatic and Pulmonary Mesenchyme of Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia. PMID: 32862424

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. PMID: 22995899

A role for MEIS1 in MLL-fusion gene leukemia. PMID: 19109563

Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma. PMID: 32372171

3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2. PMID: 35805969

Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells. PMID: 23756022

meis1 regulates the development of endothelial cells in zebrafish. PMID: 18656453

The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding. PMID: 20808819

Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion. PMID: 28462489

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. PMID: 7565694

A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1. PMID: 29296870

The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors. PMID: 24244575

MEIS1 variant as a determinant of autonomic imbalance in Restless Legs Syndrome. PMID: 28425489

Endothelin receptor emerges as a potential target of Hoxa9-mediated leukemogenesis. PMID: 30401485

Role of Retinoic Acid Signaling, FGF Signaling and Meis Genes in Control of Limb Development. PMID: 33435477

The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors. PMID: 30952900

Regulation of MEIS1 by distal enhancer elements in acute leukemia. PMID: 24022755

A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer. PMID: 21858198

Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells. PMID: 30355480

MicroRNAs mark in the MLL-rearranged leukemia. PMID: 23728610

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells. PMID: 24097337

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human MEIS1 Protein, N-His-SUMO [YHA12902]
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