Catalog No.
YHK91101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu42-Ala84
Predicted molecular weight
33.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NS69
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
1C9-2, TOM22, Translocase of outer membrane 22 kDa subunit homolog, hTom22, Mitochondrial import receptor subunit TOM22 homolog, TOMM22
Depletion of TMEM65 leads to oxidative stress, apoptosis, induction of mitochondrial unfolded protein response, and upregulation of mitochondrial protein import receptor TOMM22. PMID: 33319071
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. PMID: 29165030
A mitophagy-related gene signature associated with prognosis and immune microenvironment in colorectal cancer. PMID: 36333388
The prognostic value and clinical significance of mitophagy-related genes in hepatocellular carcinoma. PMID: 35991574
Mitochondrial accumulation of amyloid β (Aβ) peptides requires TOMM22 as a main Aβ receptor in yeast. PMID: 29925587
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response. PMID: 36217717
The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. PMID: 20483998
tomm22 Knockdown-Mediated Hepatocyte Damages Elicit Both the Formation of Hybrid Hepatocytes and Biliary Conversion to Hepatocytes in Zebrafish Larvae. PMID: 28251883
Catalpol promotes mitochondrial biogenesis in chondrocytes. PMID: 32096418
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance. PMID: 24149440
Presequence protease reverses mitochondria-specific amyloid-β-induced mitophagy to protect mitochondria. PMID: 37002885
Phoenixin 20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. PMID: 32236796
The role of miRNAs and EBV BARTs in NPC. PMID: 22178394
TIM29 is a subunit of the human carrier translocase required for protein transport. PMID: 27718247
Quantitative analysis of the human ovarian carcinoma mitochondrial phosphoproteome. PMID: 31442208
Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific Targets and Are Processed to Small RNA Species. PMID: 29861423
Construction and Validation of Prognostic Regulation Network Based on RNA-Binding Protein Genes in Lung Squamous Cell Carcinoma. PMID: 34931870
The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM). PMID: 25875815
A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart. PMID: 33526603
Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. PMID: 35733257
Multistep assembly of the protein import channel of the mitochondrial outer membrane. PMID: 11276259
Identification and functional analysis of human Tom22 for protein import into mitochondria. PMID: 10982837
Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. PMID: 33890134
Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A. PMID: 28511966
Expression of the Bcl-2 family genes and complexes involved in the mitochondrial transport in prostate cancer cells. PMID: 25177836
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. PMID: 20413099
The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy. PMID: 27164671
Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. PMID: 11027586
Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1. PMID: 22580151
Isolation of functionally active and highly purified neuronal mitochondria from human cortex. PMID: 26808294
Bax inserts into the mitochondrial outer membrane by different mechanisms. PMID: 18687331
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. PMID: 31236191
Analysis of individual mitochondria via fluorescent immunolabeling with Anti-TOM22 antibodies. PMID: 24481619
The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast. PMID: 22198199
The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator. PMID: 27592226
Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22. PMID: 24269536
An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues. PMID: 26787839
Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. PMID: 10900208
Bcl-2 and porin follow different pathways of TOM-dependent insertion into the mitochondrial outer membrane. PMID: 12419260
Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. PMID: 14699115
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. PMID: 19401463
Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity. PMID: 20107041
Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. PMID: 12198123
An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals. PMID: 18480056
Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex. PMID: 14985332
Conformation-sensitive gel electrophoresis as an ideal high-throughput strategy for accurate detection of sequence variations in DNA: screening hTomm and hTimm genes. PMID: 15475482
For research use only. Not for human or drug use.
