Catalog No.
YHB36901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly13-Gly73
Predicted molecular weight
35.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75952
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium-binding protein 86, Testis-specific calcium-binding protein CBP86, FSP2, Calcium-binding tyrosine phosphorylation-regulated protein, CBP86, Cancer/testis antigen 88, CT88, CABYR, Fibrousheathin II, FSP-2, Fibrousheathin-2
cAMP and the Fibrous Sheath Protein CABYR (Ca2+-Binding Tyrosine-Phosphorylation-Regulated Protein) Is Required for 4D Sperm Movement. PMID: 36142535
Expression of the sperm fibrous sheath protein CABYR in human cancers and identification of α-enolase as an interacting partner of CABYR-a. PMID: 21274509
CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. PMID: 11820818
CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath. PMID: 21240291
FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. PMID: 17855365
CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. PMID: 27802166
Upregulated calcium-binding tyrosine phosphorylation-regulated protein-a/b regulates cell proliferation and apoptosis and predicts poor prognosis in hepatocellular carcinoma. PMID: 31692072
Testis-specific calcium-binding protein CBP86-IV (CABYR) binds with phosphoglycerate kinase 2 in vitro and in vivo experiment. PMID: 30972801
The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy. PMID: 33747357
Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella. PMID: 30683861
Splicing in murine CABYR and its genomic structure. PMID: 12801634
CABYR is a novel cancer-testis antigen in lung cancer. PMID: 17317841
CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. PMID: 20731842
The expression and effects the CABYR-c transcript of CABYR gene in hepatocellular carcinoma. PMID: 22285430
CABYR RNAi plasmid construction and NF-κB signal transduction pathway. PMID: 20954286
Knockdown of CABYR-a/b increases chemosensitivity of human non-small cell lung cancer cells through inactivation of Akt. PMID: 24362251
Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation. PMID: 26843620
Low-expressed testis-specific calcium-binding protein CBP86-IV (CABYR) is observed in idiopathic asthenozoospermia. PMID: 25717016
Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia. PMID: 29247344
Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. PMID: 16139264
Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain. PMID: 15752768
Functional and immunological analysis of the human sperm proteome. PMID: 22459723
Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. PMID: 18421703
Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells. PMID: 28121627
FSCB phosphorylation in mouse spermatozoa capacitation. PMID: 21871179
Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens). PMID: 36277216
Loss of ASP but not ROPN1 reduces mammalian ciliary motility. PMID: 22021175
Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection. PMID: 26771610
Phosphoproteomics for the identification of new mechanisms of cryodamage: the role of SPATA18 in the control of stallion sperm function†. PMID: 36468681
Chromatin and extracellular vesicle associated sperm RNAs. PMID: 26071953
FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L. PMID: 27398160
Sperm fibrous sheath proteins: a potential new class of target antigens for use in human therapeutic cancer vaccines. PMID: 18433090
Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo (Bubalus bubalis). PMID: 32973212
Tomato spotted wilt orthotospovirus shifts sex ratio toward males in the western flower thrips, Frankliniella occidentalis, by down-regulating a FSCB-like gene. PMID: 36054039
High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. PMID: 22006429
Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa. PMID: 34336820
Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene. PMID: 30451833
Does the Pre-Ovulatory Pig Oviduct Rule Sperm Capacitation In Vivo Mediating Transcriptomics of Catsper Channels? PMID: 32155986
Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples. PMID: 24278187
Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro. PMID: 26938915
Involvement of the residues of GSKIP, AxinGID, and FRATtide in their binding with GSK3beta to unravel a novel C-terminal scaffold-binding region. PMID: 20043192
For research use only. Not for human or drug use.
