SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. PMID: 31913745
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. PMID: 11961546
AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions. PMID: 32391793
Regulation of Nrf2-an update. PMID: 23434765
The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish. PMID: 34363825
Identification of a primary target of thalidomide teratogenicity. PMID: 20223979
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. PMID: 25043012
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. PMID: 32804079
Exploring Shared Pathogenesis of Alzheimer's Disease and Type 2 Diabetes Mellitus via Co-expression Networks Analysis. PMID: 32781959
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. PMID: 30017357
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation. PMID: 30898011
Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer. PMID: 24292229
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. PMID: 34824248
Introduction. PMID: 31898218
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. PMID: 23609182
RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. PMID: 21115485
Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells. PMID: 22822056
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. PMID: 34518685
RING box protein-1 gene involved in flagellar disassembly of Dunaliella salina. PMID: 27655397
RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival. PMID: 19660140
Ring box protein-1 is associated with a poor prognosis and tumor progression in esophageal cancer. PMID: 32782608
ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling. PMID: 33962660
Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function. PMID: 12215511
The characteristics and roles of β-TrCP1/2 in carcinogenesis. PMID: 33021036
RBX1 expression is an unfavorable prognostic factor in patients with non-small cell lung cancer. PMID: 27566015
Non-coding RNAs and related molecules associated with form-deprivation myopia in mice. PMID: 34841657
Cullin 3 and Its Role in Tumorigenesis. PMID: 31898229
An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance. PMID: 20452971
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. PMID: 11384984
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. PMID: 25108355
Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase. PMID: 26909574
The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination. PMID: 35580799
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. PMID: 22405651
E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism. PMID: 35802537
Identification and functional characterization of an Rbx1 in an invertebrate Haliotis diversicolor supertexta. PMID: 20801156
F-box proteins: the key to protein degradation. PMID: 16463014
miR-194 targets RBX1 gene to modulate proliferation and migration of gastric cancer cells. PMID: 25412959
The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. PMID: 35641500
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells. PMID: 29294217
Arabidopsis jasmonate signaling pathway. PMID: 20159850
The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer. PMID: 31898228
Zeroing in on cereblon. PMID: 25777766
Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. PMID: 25912140
RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase. PMID: 31562368
F-box proteins and protein degradation: an emerging theme in cellular regulation. PMID: 11117256
Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells. PMID: 33290867
Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex. PMID: 28591624
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. PMID: 23528706
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. PMID: 10579999
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. PMID: 12149480
Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. PMID: 22748924
Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis. PMID: 14622138
Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer. PMID: 23522382
SCFs in the new millennium. PMID: 23624913
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. PMID: 35982156
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. PMID: 19325126
Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. PMID: 15966899
ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression. PMID: 31968402
ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex. PMID: 15590664
Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. PMID: 22965024
MiR-135b-5p inhibits the progression of malignant melanoma cells by targeting RBX1. PMID: 32096167
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs. PMID: 35101445
Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability. PMID: 34324733
Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2. PMID: 29658272
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. PMID: 29438612
The role of RING box protein 1 in mouse oocyte meiotic maturation. PMID: 23874827
Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer. PMID: 31898234
Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. PMID: 26540345
The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB. PMID: 29358211
Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants. PMID: 24990631
A homolog of the E3 ubiquitin ligase Rbx1 is induced during hyperosmotic stress of salmon. PMID: 12010746
Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components. PMID: 31898227
Monitoring Keap1-Nrf2 interactions in single live cells. PMID: 24681086
Identification of the self-incompatibility locus F-box protein-containing complex in Petunia inflata. PMID: 24381071
Role of Nrf2 in bisphenol effects: a review study. PMID: 35680748
The Arabidopsis ALF4 protein is a regulator of SCF E3 ligases. PMID: 29233834
Characterization of SCF-Complex during Bovine Preimplantation Development. PMID: 26824694
A20 and RBX1 Regulate Brentuximab Vedotin Sensitivity in Hodgkin Lymphoma Models. PMID: 32299816
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. PMID: 10213691
Post-translational regulation of the cellular levels of DAPK. PMID: 24185832
Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes. PMID: 32145688
Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1. PMID: 10643962
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export. PMID: 17079297
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. PMID: 23940030
Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation. PMID: 20682250
CUL4A-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor Pex7p. PMID: 24989250
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. PMID: 15571813
ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence. PMID: 19509229
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. PMID: 18381890
The proteome reveals the involvement of serine/threonine kinase in the recognition of self- incompatibility in almond. PMID: 35123051
ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex. PMID: 29628507
Involvement of F-BOX proteins in progression and development of human malignancies. PMID: 26410033
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PMID: 27706223
SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer. PMID: 31911863
Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets. PMID: 21103004
Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function. PMID: 34863825
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. PMID: 26334369
Nrf2 signaling and cell survival. PMID: 19538984
Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. PMID: 22072718
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. PMID: 23912815
[TGF-beta signaling]. PMID: 16922387
Nedd8 on cullin: building an expressway to protein destruction. PMID: 15021886
Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2. PMID: 19279002
Cullin-RING Ligase 5: Functional characterization and its role in human cancers. PMID: 32334051
Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation. PMID: 22910413
Expression and purification of functional recombinant Cullin1-Rbx1/2 in E. coli., PMID:40447239
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α., PMID:40436847
RBX1 mitigates ferroptosis by inhibiting NCOA4-mediated ferritinophagy and contributes to the attenuation of intervertebral disc degeneration., PMID:40335979
Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models., PMID:40222426
Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes., PMID:40211562
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin., PMID:40208944
RING box protein-1 promotes the metastasis of cervical cancer through regulating matrix metalloproteinases via PI3K/AKT signaling pathway., PMID:40153066
The cross-talk between NRF2 and apoptosis in cancer., PMID:40126632
LRRK2 reduces the sensitivity to TKI and PD-1 blockade in ccRCC via activating LPCAT1., PMID:40121376
Pan-cancer analysis unveils the role and mechanisms of neddylation modifications in tumorigenesis., PMID:40106140
Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer., PMID:40033163
GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato., PMID:40022479
SPOP Suppresses Hepatocellular Carcinoma Growth and Metastasis by Ubiquitination and Proteasomal Degradation of TRAF6., PMID:39962908
Impairment of DET1 causes neurological defects and lethality in mice and humans., PMID:39937864
Structural Insight Into the SKP1-CUL1-FBXO3-RBX1 Complex., PMID:39921442
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle., PMID:39878121
Identification of core biomarkers for tuberculosis progression through bioinformatics analysis and in vitro research., PMID:39856190
F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1., PMID:39836692
The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation., PMID:39708321
Spop deficiency impairs adipogenesis and promotes thermogenic capacity in mice., PMID:39680603
Establishment of the auxin inducible degron system for Babesia duncani: a conditional knockdown tool to study precise protein regulation in Babesia spp., PMID:39478572
A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases., PMID:39456142
Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K., PMID:39450271
Structure of the CUL1-RBX1-SKP1-FBXO4 SCF ubiquitin ligase complex., PMID:39406020
Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation., PMID:39307307
A multistage Plasmodium CRL4WIG1 ubiquitin ligase is critical for the formation of functional microtubule organization centers in microgametocytes., PMID:39207167
PDLIM2 is a novel E5 ubiquitin ligase enhancer that stabilizes ROC1 and recruits the ROC1-SCF ubiquitin ligase to ubiquitinate and degrade NF-κB RelA., PMID:39080804
The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics., PMID:39075067
Functional characterization of Cullin-1-RING ubiquitin ligase (CRL1) complex in Leishmania infantum., PMID:39018347
TRAF2 associates with cullin neddylation complex assembly., PMID:38978293
Mapping the IMiD-dependent cereblon interactome using BioID-proximity labelling., PMID:38975872
Investigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster., PMID:38925484
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes., PMID:38798357
Allicin regulates Sestrin2 ubiquitination to affect macrophage autophagy and senescence, thus inhibiting the growth of hepatoma cells., PMID:38728949
SCFFBXW5-mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells., PMID:38726865
In vivo evaluation of mebendazole and Ran GTPase inhibition in breast cancer model system., PMID:38661720
Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF., PMID:38653919
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex., PMID:38625940
Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex., PMID:38605244
Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis., PMID:38486234
Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity., PMID:38416790
Modulation of Cullin-RING E3 ubiquitin ligase-dependent ubiquitination by small molecule compounds., PMID:38354780
Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancers., PMID:38280358
CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection by targeting ORF6 for ubiquitin-dependent degradation., PMID:38265236
The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women., PMID:38238750
The CUL3A-LFH1-UBC15 ubiquitin ligase complex mediates SHORT VEGETATIVE PHASE degradation to accelerate flowering at high ambient temperature., PMID:38213026
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype., PMID:38036533
SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α., PMID:38018242
Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1., PMID:38005838
Brain Gene Co-Expression Network Analysis Identifies 22q13 Region Genes Associated with Autism, Intellectual Disability, Seizures, Language Impairment, and Hypotonia., PMID:38002941
For research use only. Not for human or drug use.
