Catalog No.
YHK90601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys446-Arg520
Predicted molecular weight
36.82 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6X8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ZHX2, Alpha-fetoprotein regulator 1, AFR1, RAF, AFP regulator 1, Zinc finger and homeodomain protein 2, KIAA0854, Zinc fingers and homeoboxes protein 2, Regulator of AFP
ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer. PMID: 34779768
USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer. PMID: 36037364
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3. PMID: 32179636
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. PMID: 30026228
Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity. PMID: 34279541
ZHX2 in health and disease. PMID: 36465389
The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog. PMID: 34545586
HNRNPD interacts with ZHX2 regulating the vasculogenic mimicry formation of glioma cells via linc00707/miR-651-3p/SP2 axis. PMID: 33542193
Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver. PMID: 28258223
ZHX2 inhibits thyroid cancer metastasis through transcriptional inhibition of S100A14. PMID: 35151335
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases. PMID: 32059999
ZHX2 mediates proteasome inhibitor resistance via regulating nuclear translocation of NF-κB in multiple myeloma. PMID: 32780537
ZHX2 inhibits proliferation and promotes apoptosis of human lung cancer cells through targeting p38MAPK pathway. PMID: 31683461
ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p. PMID: 32770671
Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake. PMID: 31740790
Low expression of ZHX1 and ZHX2 impacts on the prognosis of chronic lymphocytic leukemia. PMID: 33541423
Upregulation of ZHX2 predicts poor prognosis and is correlated with immune infiltration in gastric cancer. PMID: 33837660
Novel regulation of the transcription factor ZHX2 by N-terminal methylation. PMID: 35613330
HBV suppresses ZHX2 expression to promote proliferation of HCC through miR-155 activation. PMID: 29752719
ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation. PMID: 32114388
Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. PMID: 30026271
ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. PMID: 18194454
The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development. PMID: 30146259
ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma. PMID: 32382017
ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA. PMID: 25473899
Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non-epigenetic manners. PMID: 29580980
ZHX2 and ZHX3 repress cancer markers in normal hepatocytes. PMID: 19273305
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1. PMID: 35398991
Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma. PMID: 25195714
Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice. PMID: 36194180
Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward. PMID: 35688478
[Role of ZHX2 in regulating dorsal root ganglion μ-opioid receptor expression in mice with peripheral nerve injuryinduced pain hypersensitivity]. PMID: 31511211
Promoter hypermethylation of a novel gene, ZHX2, in hepatocellular carcinoma. PMID: 16707376
Cytokine storm-based mechanisms for extrapulmonary manifestations of SARS-CoV-2 infection. PMID: 37040185
Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. PMID: 27197076
[The methylation of ZHX2 gene promoter enhances AFP gene expression in hepatocellular carcinoma]. PMID: 23837980
Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma. PMID: 22078940
The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. PMID: 14659886
ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. PMID: 19515908
Targeting genes and signaling pathways of transcriptional suppressor ZHX2 in hepatocellular carcinoma: a Chromatin Immunoprecipitation-sequencing (ChIP-seq) investigation. PMID: 30784286
Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis. PMID: 17447851
Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer. PMID: 21216289
Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E. PMID: 22406477
Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2. PMID: 31321500
Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. PMID: 12741956
Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. PMID: 28574502
t(4;8)(q27;q24) in Hodgkin lymphoma cells targets phosphodiesterase PDE5A and homeobox gene ZHX2. PMID: 21987443
Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism. PMID: 20160197
Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway. PMID: 36746874
Zinc Fingers and Homeobox Family in Cancer: A Double-Edged Sword. PMID: 36232466
Regulation of cell differentiation by Eph receptor and ephrin signaling. PMID: 25482623
Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains. PMID: 20509910
Hereditary persistence of alpha-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene. PMID: 15626755
Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. PMID: 25701010
Proliferation and osteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study. PMID: 26679602
Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma. PMID: 18353163
Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice. PMID: 36098436
Attenuated ZHX3 expression serves as a potential biomarker that predicts poor clinical outcomes in breast cancer patients. PMID: 30787639
Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation. PMID: 17041810
Development and validation of novel prognostic models for zinc finger proteins-related genes in soft tissue sarcoma. PMID: 37100454
Evolutionary Analysis of the Zinc Finger and Homeoboxes Family of Proteins Identifies Multiple Conserved Domains and a Common Early Chordate Ancestor. PMID: 32125369
Lack of association of G779A ZHX-2 gene variant with HbF levels in β-thalassemia major. PMID: 21443521
Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PMID: 33909629
Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson's Disease. PMID: 34946922
The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2. PMID: 17668883
Deregulated FOX genes in Hodgkin lymphoma. PMID: 25043849
Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia. PMID: 27923400
LncRNA PART1 Promotes Proliferation and Migration, Is Associated with Cancer Stem Cells, and Alters the miRNA Landscape in Triple-Negative Breast Cancer. PMID: 34072264
Prognostic value and therapeutic implications of ZHX family member expression in human gastric cancer. PMID: 32774706
ZBTB20 is involved in liver regeneration after partial hepatectomy in mouse. PMID: 24463079
Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma. PMID: 28152006
Expression of new red cell-related genes in erythroid differentiation. PMID: 19941055
Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma. PMID: 32164487
Genome-wide association study of antibody response to smallpox vaccine. PMID: 22542470
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer. PMID: 25625310
Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma. PMID: 26406991
Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages. PMID: 27521061
Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage. PMID: 26881698
Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. PMID: 28922406
ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. PMID: 17056598
A missense mutation in podocin leads to early and severe renal disease in mice. PMID: 18288100
Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA. PMID: 33763493
Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis. PMID: 23456299
Construction of a recombinant eukaryotic human ZHX1 gene expression plasmid and the role of ZHX1 in hepatocellular carcinoma. PMID: 24064680
Investigating the genetic profile of familial atypical cystic fibrosis patients (DeltaF508-CFTR) with neonatal biliary atresia. PMID: 36205856
Early changes in gene expression that influence the course of primary glomerular disease. PMID: 17457373
PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor. PMID: 26085845
Characterization of early stages of human B cell development by gene expression profiling. PMID: 17785802
Analysis of adult cerebral cortex and hippocampus transcriptomes reveals unique molecular changes in the Ts1Cje mouse model of down syndrome. PMID: 24916381
Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. PMID: 25746325
The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension. PMID: 19348505
Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. PMID: 20568903
Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster. PMID: 16952470
Prenatal diagnosis and array comparative genomic hybridization characterization of interstitial deletions of 8q23.3-q24.11 and 8q24.13 associated with Langer-Giedion syndrome, Cornelia de Lange syndrome and haploinsufficiency of TRPS1, RAD21 and EXT1. PMID: 26522117
For research use only. Not for human or drug use.
