Catalog No.
YHK04802
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser130-Phe248
Predicted molecular weight
25.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IWL2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Collectin-4, Pulmonary surfactant-associated protein A1, SFTP1, SP-A1, COLEC4, SP-A, PSP-A, SFTPA1, SFTPA1B, Alveolar proteinosis protein, SFTPA, PSPA, PSAP, 35 kDa pulmonary surfactant-associated protein
Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants. PMID: 34917085
SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma. PMID: 34181042
Lung cancer is also a hereditary disease. PMID: 34670806
Surfactant protein A signaling pathways in human uterine smooth muscle cells. PMID: 18463356
Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis. PMID: 30333828
Direct interaction of surfactant protein A with myometrial binding sites: signaling and modulation by bacterial lipopolysaccharide. PMID: 17202387
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis. PMID: 31601679
Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. PMID: 16292672
Pulmonary Fibrosis Predisposition Overview. PMID: 20301408
Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model. PMID: 36200269
Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. PMID: 16429424
Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer. PMID: 32855221
Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs. PMID: 30827536
Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis. PMID: 35720392
Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences. PMID: 29394894
A novel germline mutation of the SFTPA1 gene in familial interstitial pneumonia. PMID: 30854216
The Genetic and Epigenetic Footprint in Idiopathic Pulmonary Fibrosis and Familial Pulmonary Fibrosis: A State-of-the-Art Review. PMID: 36553114
Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer. PMID: 26792177
Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy. PMID: 33863742
Identification and examination of a novel 9-bp insert/deletion polymorphism on porcine SFTPA1 exon 2 associated with acute lung injury using an oleic acid-acute lung injury model. PMID: 25442010
An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. PMID: 24793167
Novel rare genetic variants in idiopathic pulmonary fibrosis. PMID: 33361455
Association of SNP-SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure. PMID: 32326132
Surfactant protein A--from genes to human lung diseases. PMID: 17168848
Long-range PCR based sequencing of the highly homologous genes, SFTPA1 and SFTPA2. PMID: 23354021
Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. PMID: 23069847
Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions. PMID: 34484180
Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences. PMID: 31475015
Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. PMID: 20693318
Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China. PMID: 24984162
Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. PMID: 29969487
[Interstitial lung diseases in children of genetic origin]. PMID: 36564324
Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. PMID: 20048345
Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants. PMID: 34671583
Hyaline membrane disease and surfactant protein, SAP-35, in diabetes in pregnancy. PMID: 3048286
Genetic causes and clinical management of pediatric interstitial lung diseases. PMID: 29517585
Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis. PMID: 32005219
Surfactant protein A is defective in abrogating inflammation in asthma. PMID: 21784968
SNP-SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children. PMID: 35401703
Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function. PMID: 19392648
A new tool to investigate differences between human SP-A1 and SP-A2. PMID: 17293378
Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help? PMID: 24960334
Krebs von den Lungen-6 and surfactant protein-A in interstitial pneumonia with autoimmune features. PMID: 33530214
Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films. PMID: 27508436
Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates. PMID: 27835691
Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection. PMID: 24950659
Genetic characterization of a Chinese family with familial idiopathic pulmonary fibrosis. PMID: 22884059
Persistent Respiratory Distress in the Term Neonate: Genetic Surfactant Deficiency Diseases. PMID: 31544695
GLP-1 receptor agonist ameliorates experimental lung fibrosis. PMID: 33093510
Insertions and Deletions Target Lineage-Defining Genes in Human Cancers. PMID: 28089356
Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children. PMID: 35903101
Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. PMID: 19797132
Immunologic identification of a pulmonary surfactant-associated protein of molecular weight = 6000 daltons. PMID: 3526265
The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. PMID: 21840962
Peptide regulation of gene expression and protein synthesis in bronchial epithelium. PMID: 25015171
Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. PMID: 20466729
Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. PMID: 25025725
Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae. PMID: 32670284
DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. PMID: 25514367
Injury activated alveolar progenitors (IAAPs): the underdog of lung repair. PMID: 37166489
Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population. PMID: 20963503
14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA. PMID: 26001776
Surfactant protein A2 gene expression by human airway submucosal gland cells. PMID: 9698591
SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population. PMID: 33469544
CRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung. PMID: 33980985
Dexamethasone Treatment Increases the Intracellular Calcium Level Through TRPV6 in A549 Cells. PMID: 32033337
Systematic review of drug effects in humans and models with surfactant-processing disease. PMID: 29997245
Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study. PMID: 21310059
Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival. PMID: 30459763
Genetics of the hydrophilic surfactant proteins A and D. PMID: 9813381
Structural characterisation of human proteinosis surfactant protein A. PMID: 11087951
Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. PMID: 25326576
Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. PMID: 23525782
Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells. PMID: 23926107
Non-invasive prenatal testing reveals copy number variations related to pregnancy complications. PMID: 31485271
Effect of surfactant protein A on lipopolysaccharide-induced tumor necrosis factor-α expression in human proximal tubular epithelial cells. PMID: 24438626
Alveolyn--structure and source: a review. PMID: 6386449
Surfactant-associated protein inhibits phospholipid secretion from type II cells. PMID: 3654429
Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. PMID: 17220308
Surfactant protein (SP) B associations and interactions with SP-A in white and black subjects with respiratory distress syndrome. PMID: 11737731
SP-A and TLR4 localization in lung tissue of SM-exposed patients. PMID: 31718931
Polymorphisms of surfactant protein A genes and the risk of bronchopulmonary dysplasia in preterm infants. PMID: 11105614
Differential effects of human SP-A1 and SP-A2 variants on phospholipid monolayers containing surfactant protein B. PMID: 17678872
miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/β-Catenin Signaling. PMID: 33490270
Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population. PMID: 10762543
Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. PMID: 17407567
Genetic variants of small airways and interstitial pulmonary disease in children. PMID: 33526882
Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B. PMID: 9475280
Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-κB. PMID: 21474333
5' splicing and allelic variants of the human pulmonary surfactant protein A genes. PMID: 7811473
Autophagy proteins are required for club cell structure and function in airways. PMID: 31116580
Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line. PMID: 10781424
For research use only. Not for human or drug use.
