Catalog No.
YHJ77702
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys75-Gly133
Predicted molecular weight
18.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UIK5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Transmembrane protein with EGF-like and two follistatin-like domains, TENB2, Hyperplastic polyposis protein 1, TR-2, HPP1, TMEFF2, TPEF, Tomoregulin-2
TMEFF2: A Transmembrane Proteoglycan with Multifaceted Actions in Cancer and Disease. PMID: 33371267
TMEFF2 is an endogenous inhibitor of the CRH signal transduction pathway. PMID: 25573902
TMEFF2 is a novel prognosis signature and target for endometrial carcinoma. PMID: 31610211
A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells. PMID: 16439095
TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma. PMID: 21559523
TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas. PMID: 33663520
TMEFF2 deregulation contributes to gastric carcinogenesis and indicates poor survival outcome. PMID: 24987055
Generation and characterization of Tmeff2 mutant mice. PMID: 22828515
Bidirectional regulation between TMEFF2 and STAT3 may contribute to Helicobacter pylori-associated gastric carcinogenesis. PMID: 24996057
The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels. PMID: 21393249
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. PMID: 23824605
TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer. PMID: 28762604
Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. PMID: 10903839
Analysis of TMEFF2 allografts and transgenic mouse models reveals roles in prostate regeneration and cancer. PMID: 26417683
MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways. PMID: 32009129
Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the α subunit of the translation initiation factor 2. PMID: 23405127
Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo. PMID: 28336932
TMEFF2 modulates the AKT and ERK signaling pathways. PMID: 23936739
The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. PMID: 24632071
Upregulation of TMEFF2 is involved in the antiproliferative effects of vitamin C and tyrphostin AG490 on GES-1 and AGS cells. PMID: 30655813
Repression of the TMEFF2 promoter by c-Myc. PMID: 12729735
Methylation of TMEFF2 gene in tissue and serum DNA from patients with non-small cell lung cancer. PMID: 22814847
Expression of TMEFF2 in Human Pancreatic Cancer Tissue and the Effects of TMEFF2 Knockdown on Cell, Proliferation, and Apoptosis in Human Pancreatic Cell Lines. PMID: 31044775
A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer. PMID: 31060542
Prognostic and clinicopathological significance of TMEFF2, SMOC-2, and SOX17 expression in endometrial carcinoma. PMID: 34339705
Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer. PMID: 15299075
TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway. PMID: 31920328
Frameshift mutation of candidate tumor suppressor genes QK1 and TMEFF2 in gastric and colorectal cancers. PMID: 30614793
The effect of TMEFF2 methylation on the tumor stage and survival outcome of clear cell renal cell carcinoma. PMID: 28128743
TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells. PMID: 12101412
Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. PMID: 17942404
Expression of TMEFF1 mRNA in the mouse central nervous system: precise examination and comparative studies of TMEFF1 and TMEFF2. PMID: 11165370
Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2. PMID: 32559621
The MAPK Pathway-Based Drug Therapeutic Targets in Pituitary Adenomas. PMID: 31231308
Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity. PMID: 26402097
Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. PMID: 19288010
Roles of a TMPO-AS1/microRNA-200c/TMEFF2 ceRNA network in the malignant behaviors and 5-FU resistance of ovarian cancer cells. PMID: 32497621
Quantitative DNA methylation analysis of selected genes in endometrial carcinogenesis. PMID: 26522113
DNA methylation based biomarkers in colorectal cancer: A systematic review. PMID: 27385266
Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models. PMID: 21814219
Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples. PMID: 20975101
The role of EGF-related peptides in tumor growth. PMID: 11333208
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity. PMID: 35149761
Detection of colorectal cancer in urine using DNA methylation analysis. PMID: 33504902
Molecular staging of surgical margins in oral squamous cell carcinoma using promoter methylation of p16(INK4A), cytoglobin, E-cadherin, and TMEFF2. PMID: 23111707
Accurate detection of upper tract urothelial carcinoma in tissue and urine by means of quantitative GDF15, TMEFF2 and VIM promoter methylation. PMID: 24100025
Potential genes and pathways associated with heterotopic ossification derived from analyses of gene expression profiles. PMID: 34389038
Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. PMID: 11025219
A Data Science Approach for the Identification of Molecular Signatures of Aggressive Cancers. PMID: 35565454
Impact of FecB Mutation on Ovarian DNA Methylome in Small-Tail Han Sheep. PMID: 36672944
HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. PMID: 11120884
Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study. PMID: 27799384
Aberrant DNA methylation of tumor-related genes in oral rinse: a noninvasive method for detection of oral squamous cell carcinoma. PMID: 22252571
Distinct TPEF/HPP1 gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis. PMID: 18799374
Tomoregulin ectodomain shedding by proinflammatory cytokines. PMID: 12875894
Targeting tomoregulin for radioimmunotherapy of prostate cancer. PMID: 15805286
The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. PMID: 10987305
The identification of specific methylation patterns across different cancers. PMID: 25774687
HPP1 Ectodomain Shedding is Mediated by ADAM17 and is Necessary for Tumor Suppression in Colon Cancer. PMID: 32450419
Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer. PMID: 20804913
ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1. PMID: 27029064
Global gene analysis of oocytes from early stages in human folliculogenesis shows high expression of novel genes in reproduction. PMID: 22238370
Promoter CpG island hypermethylation during breast cancer progression. PMID: 21120523
Anti-tumor efficacy of chitosan-g-poly(ethylene glycol) nanocapsules containing docetaxel: anti-TMEFF-2 functionalized nanocapsules vs. non-functionalized nanocapsules. PMID: 23262164
Novel biomarkers for prostate cancer including noncoding transcripts. PMID: 19893039
Identification of differentially expressed genes and their upstream regulators in colorectal cancer. PMID: 28409560
Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles. PMID: 25861799
Induction of apoptosis in hematopoietic cells with an antibody against tomoregulin-1. PMID: 16475715
Validation of DNA promoter hypermethylation biomarkers in breast cancer--a short report. PMID: 25123395
DNA methylation biomarkers for blood-based colorectal cancer screening. PMID: 18089654
HPP1-mediated tumor suppression requires activation of STAT1 pathways. PMID: 18059030
Aberrant methylation of tumour-related genes in thymic epithelial tumours. PMID: 18778870
Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer. PMID: 24708595
The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. PMID: 24919179
Prevention of PCR cross-contamination by UNG treatment of bisulfite-treated DNA. PMID: 18987827
Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain. PMID: 16805794
The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways. PMID: 26061044
Prognostic role of methylated free circulating DNA in colorectal cancer. PMID: 22362391
GREB1 tissue expression is associated with organ-confined prostate cancer. PMID: 19945309
Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium. PMID: 11870232
Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection. PMID: 22791128
[Multi-gene methylation detection increases positive methylation rate in colorectal cancer]. PMID: 22736139
Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer. PMID: 28124380
Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. PMID: 17408633
For research use only. Not for human or drug use.
