Catalog No.
YHK89601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser66-Asp114
Predicted molecular weight
17.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86YF9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DAZ-interacting protein 1/2, DZIP1, Zinc finger protein DZIP1, DZIP, KIAA0996, DZIP2
DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism. PMID: 33811421
Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF. PMID: 32051257
DZIP1 Expression as a Prognostic Marker in Gastric Cancer: A Bioinformatics-Based Analysis. PMID: 34557018
Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding. PMID: 32491167
DZIP1 Promotes Proliferation, Migration, and Invasion of Oral Squamous Carcinoma Through the GLI1/3 Pathway. PMID: 31450126
CEP290 is essential for the initiation of ciliary transition zone assembly. PMID: 33370260
GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PMID: 25860027
Loss of zebrafish dzip1 results in inappropriate recruitment of periocular mesenchyme to the optic fissure and ocular coloboma. PMID: 35286359
DZIP1 expressed in fibroblasts and tumor cells may affect immunosuppression and metastatic potential in gastric cancer. PMID: 36805200
Characterization of structure and expression of the Dzip1 gene in the rat and mouse. PMID: 16368222
Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila. PMID: 31821146
Ribonomic analysis of human DZIP1 reveals its involvement in ribonucleoprotein complexes and stress granules. PMID: 24993635
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. PMID: 23955340
Comparative analysis of genes regulated by Dzip1/iguana and hedgehog in zebrafish. PMID: 25476803
DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. PMID: 27979967
Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease. PMID: 22355768
Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling. PMID: 24072710
Mutations in DZIP1 and XYLT1 are associated with nonsyndromic early onset high myopia in the Korean population. PMID: 28085539
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. PMID: 15115751
Genetic background of mitral valve prolapse. PMID: 35345263
The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. PMID: 20014402
The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. PMID: 21878643
Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish. PMID: 20487519
Genetics and pathophysiology of mitral valve prolapse. PMID: 36873395
Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease. PMID: 22570624
Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis. PMID: 34873924
Primary cilia defects causing mitral valve prolapse. PMID: 31118289
Hedgehog signaling pathway and gastric cancer. PMID: 16258256
Exploration of hub genes, lipid metabolism, and the immune microenvironment in stomach carcinoma and cholangiocarcinoma. PMID: 36034995
Hedgehog signaling: iguana debuts as a nuclear gatekeeper. PMID: 15324687
Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. PMID: 20156556
Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004
Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta. PMID: 32294443
Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. PMID: 24063361
Epigenetic regulation of KLHL34 predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. PMID: 25680604
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation. PMID: 22433712
Metal-metal interaction mediates the iron induction of Drosophila MtnB. PMID: 28435068
Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning. PMID: 19540935
[GTW-induced abnormal expressions of testicular reproduction-related genes and intervention with kidney-tonifying Chinese herbs]. PMID: 22741448
Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells. PMID: 31174021
WNT antagonist, SFRP1, is Hedgehog signaling target. PMID: 16328026
Regulation and function of foxe3 during early zebrafish development. PMID: 18327772
Identification of known and unknown genes associated with mitral valve prolapse using an exome slice methodology. PMID: 32277046
The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. PMID: 19852954
Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. PMID: 26411574
TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. PMID: 28543567
Proteomic analysis of anti-aging effects of Dendrobium nobile Lindl. alkaloids in aging-accelerated SAMP8 mice. PMID: 37150330
A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. PMID: 16839543
A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. PMID: 26545796
Differential regulation of the zebrafish orthopedia 1 gene during fate determination of diencephalic neurons. PMID: 17074092
Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. PMID: 25562517
Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. PMID: 15081113
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. PMID: 15198976
Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. PMID: 16246323
For research use only. Not for human or drug use.
