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Recombinant Human DMAP1 Protein, N-His

Catalog #:   YHK89201 Specific References (120) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q9NPF5
Protein length: Lys91-Ala207
Overview

Catalog No.

YHK89201

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Lys91-Ala207

Predicted molecular weight

16.69 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9NPF5

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

KIAA1425, DMAP1, DNMAP1, DNA methyltransferase 1-associated protein 1, DNMT1-associated protein 1

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human DMAP1 protein
References

CDK4/6 inhibition triggers anti-tumour immunity. PMID: 28813415

MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins. PMID: 32403252

DMAP1 is an essential regulator of ATM activity and function. PMID: 23318425

Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. PMID: 19845771

Distinct roles of DMAP1 in mouse development. PMID: 21383065

The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes. PMID: 14734556

RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity. PMID: 31531894

Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase 1-DMAP1 complex in female fecundity. PMID: 30553276

C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer. PMID: 34834420

Comprehensive Combined Proteomics and Genomics Analysis Identifies Prognostic Related Transcription Factors in Breast Cancer and Explores the Role of DMAP1 in Breast Cancer. PMID: 20864525

DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair. PMID: 30932271

CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors. PMID: 24947515

The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response. PMID: 24559687

Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. PMID: 10888872

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. PMID: 14978102

Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. PMID: 20920467

Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression. PMID: 20387133

Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells. PMID: 31783872

Correction to: c-Src confers resistance to mitotic stress through inhibition of DMAP1/Bub3 complex formation in pancreatic cancer. PMID: 32272809

ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition. PMID: 17371848

Corepressor MMTR/DMAP1 is involved in both histone deacetylase 1- and TFIIH-mediated transcriptional repression. PMID: 17214966

Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. PMID: 26206665

MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome. PMID: 29270191

Tissue-Specific Expression of DNA Methyltransferases Involved in Early-Life Nutritional Stress of Chicken, Gallus gallus. PMID: 21944426

Epstein-Barr virus-associated gastric carcinoma. PMID: 30396999

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. PMID: 20107327

Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells. PMID: 25042654

DNA methylation inhibition: a novel therapeutic strategy for heart failure. PMID: 26585710

Metabolic-epigenetic crosstalk in macrophage activation. PMID: 25838424

Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitro. PMID: 30542120

Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. PMID: 32153366

DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth. PMID: 14665632

Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. PMID: 16570848

Establishment and maintenance of DNA methylation patterns in mammals. PMID: 11389535

DNA methylation, nuclear structure, gene expression and cancer. PMID: 30397228

Epigenome-wide methylation differences in a group of lean and obese women - A HUNT Study. PMID: 31838136

NALP3 orchestrates cellular bioenergetics to facilitate non-small cell lung cancer cell growth. PMID: 16049569

Chromatin, DNA methylation and neuron gene regulation--the purpose of the package. PMID: 32686935

Transcriptional Changes in the Ovaries of Perch from Chernobyl. PMID: 17965604

On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme. PMID: 36773604

Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas. PMID: 23809695

Specific inhibition of one DNMT1-including complex influences tumor initiation and progression. PMID: 25960197

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. PMID: 27664947

Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain. PMID: 15367675

Subcellular localization of RPB5-mediating protein and its putative functional partner. PMID: 15240889

Cre-lox-regulated conditional RNA interference from transgenes. PMID: 25197808

HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. PMID: 24937014

Selective role for DNMT3a in learning and memory. PMID: 30305430

IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5. PMID: 20499676

[Mechanism of DNA methylation and demethylation--its role in control of genes expression]. PMID: 26095369

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. PMID: 26975253

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome. PMID: 23241950

Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice. PMID: 35345359

Differential Expression of Zinc-Dependent HDAC Subtypes and their Involvement in Unique Pathways Associated with Carcinogenesis. PMID: 21619587

PKC isoforms interact with and phosphorylate DNMT1. PMID: 33387775

The anti-lipidemic drug simvastatin modifies epigenetic biomarkers in the amphipod Gammarus locusta. PMID: 29466247

Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. PMID: 26721438

Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. PMID: 27487275

DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma? PMID: 18567946

The early expressed HIV-1 genes regulate DNMT1 expression. PMID: 23145775

Reactivation of RASSF1A in breast cancer cells by curcumin. PMID: 17967891

LSH cooperates with DNA methyltransferases to repress transcription. PMID: 17931718

DNMT1 interacts with the developmental transcriptional repressor HESX1. PMID: 32861793

Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer. PMID: 14712760

[DNA methylation and cancer--DNA methylation as a target of cancer chemotherapy]. PMID: 31365782

MiR-424 prevents astrogliosis after cerebral ischemia/reperfusion in elderly mice by enhancing repressive H3K27me3 via NFIA/DNMT1 signaling. PMID: 15033475

Physical and functional interactions between Daxx and TSG101. PMID: 26606905

High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice. PMID: 19110320

Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. PMID: 20081831

DNMT1 maintains progenitor function in self-renewing somatic tissue. PMID: 26257392

Chronic inflammation response as a key factor in polycystic ovary syndrome among patients with bipolar disorder., PMID:39988136

Incidence of alternative splicing associated with sex and opioid effects in the axon guidance pathway., PMID:39756548

The DNA methyltransferase DMAP1 is required for tissue maintenance and planarian regeneration., PMID:39179016

Structure of the human TIP60 complex., PMID:39154037

Regulation of the RB1 Gene through DNMT1 by SGI-1027 and its Impact on the Growth and Metastasis of Gastric Cancer Cells., PMID:38798252

The DNA Methyltransferase DMAP1 is Required for Tissue Maintenance and Planarian Regeneration., PMID:38645093

LOXL2-mediated chromatin compaction is required to maintain the oncogenic properties of triple-negative breast cancer cells., PMID:38451841

De novo variants predicting haploinsufficiency for DIP2C are associated with expressive speech delay., PMID:38421105

Identification, characterization, and CADD analysis of Plasmodium DMAP1 reveals it as a potential molecular target for new anti-malarial discovery., PMID:38217317

Novel function of the PsDMAP1 protein in regulating the growth and pathogenicity of Phytophthora sojae., PMID:37802447

Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas., PMID:36773604

Differential Expression of Zinc-Dependent HDAC Subtypes and their Involvement in Unique Pathways Associated with Carcinogenesis., PMID:35345359

Comprehensive Combined Proteomics and Genomics Analysis Identifies Prognostic Related Transcription Factors in Breast Cancer and Explores the Role of DMAP1 in Breast Cancer., PMID:34834420

The anti-lipidemic drug simvastatin modifies epigenetic biomarkers in the amphipod Gammarus locusta., PMID:33387775

Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis., PMID:33195466

Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer., PMID:32861793

MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins., PMID:32403252

ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition., PMID:32272809

DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth., PMID:32153366

NALP3 orchestrates cellular bioenergetics to facilitate non-small cell lung cancer cell growth., PMID:31838136

Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase 1-DMAP1 complex in female fecundity., PMID:31531894

Inhibition of anti-viral responses in intestinal epithelial cells by epigenetic modifying drugs is mediated by a reduction in viral pattern recognition receptor expression and activity., PMID:31505962

MiR-424 prevents astrogliosis after cerebral ischemia/reperfusion in elderly mice by enhancing repressive H3K27me3 via NFIA/DNMT1 signaling., PMID:31365782

CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors., PMID:30932271

C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer., PMID:30553276

Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma., PMID:30542120

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons., PMID:30396999

IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5., PMID:30305430

Decreased Expression of Serine/Arginine-Rich Splicing Factor 1 in T Cells From Patients With Active Systemic Lupus Erythematosus Accounts for Reduced Expression of RasGRP1 and DNA Methyltransferase 1., PMID:29905030

Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1., PMID:29466247

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome., PMID:29281720

Tissue-Specific Expression of DNA Methyltransferases Involved in Early-Life Nutritional Stress of Chicken, Gallus gallus., PMID:29270191

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells., PMID:29107996

Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation., PMID:29046054

5-Aza-2'-deoxycytidine induces human Tenon's capsule fibroblasts differentiation and fibrosis by up-regulating TGF-β type I receptor., PMID:28893564

CDK4/6 inhibition triggers anti-tumour immunity., PMID:28813415

HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6., PMID:28665981

Vitamin E Modifies High-Fat Diet-Induced Increase of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice., PMID:28613268

Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system., PMID:28475823

Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas., PMID:27159259

Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain., PMID:27664947

DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?, PMID:27487275

The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition., PMID:26774338

A Patient With DNMT1 Gene Mutation Presenting With Polyneuropathy, Hearing Loss, and Personality Changes., PMID:26747177

Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication., PMID:26721438

In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas- Tragedy survivors., PMID:26625778

High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice., PMID:26606905

Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β., PMID:26599461

Metabolic-epigenetic crosstalk in macrophage activation., PMID:26585710

Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation., PMID:26257392

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human DMAP1 Protein, N-His [YHK89201]
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