Neurofibromatosis type 1. PMID: 28230061
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. PMID: 31786184
Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside. PMID: 31023785
The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis. PMID: 27845897
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. PMID: 32979540
Long noncoding RNA as modular scaffold of histone modification complexes. PMID: 20616235
Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML. PMID: 34482403
Imagawa-Matsumoto syndrome: SUZ12-related overgrowth disorder. PMID: 36645289
JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation. PMID: 35649353
MARCKSL1-2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b. PMID: 35864549
Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. PMID: 21480320
Molecular biomarkers for uterine leiomyosarcoma and endometrial stromal sarcoma. PMID: 29660202
Polycomb group protein Suz12 is regulated by a novel miRNA-like small RNA. PMID: 29379063
Molecular characterization of diffuse malignant peritoneal mesothelioma. PMID: 32504035
SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels. PMID: 34990019
Rare SUZ12 variants commonly cause an overgrowth phenotype. PMID: 31736240
JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas. PMID: 26879382
Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. PMID: 16712789
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. PMID: 29351847
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. PMID: 17339329
Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A). PMID: 31957467
SUZ12 RNA interference inhibits the invasion of gastric carcinoma cells. PMID: 25699394
Novel SUZ12 mutations in Weaver-like syndrome. PMID: 30019515
Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer. PMID: 33431674
Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma. PMID: 20558579
The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. PMID: 17406994
SUZ12 is a novel putative oncogene promoting tumorigenesis in head and neck squamous cell carcinoma. PMID: 29667751
PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing. PMID: 36476474
SUZ12 depletion suppresses the proliferation of gastric cancer cells. PMID: 23735840
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. PMID: 18555785
ARE/SUZ12 dual specifically-regulated adenoviral TK/GCV system for CML blast crisis cells. PMID: 26017281
SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin. PMID: 25672609
Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia. PMID: 31492675
SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK. PMID: 22964433
CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site. PMID: 36351927
SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis. PMID: 24633887
Deregulation of epigenetic mechanisms by the hepatitis B virus X protein in hepatocarcinogenesis. PMID: 23507839
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. PMID: 29499137
RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. PMID: 34928964
The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex. PMID: 36464274
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. PMID: 15385962
PRC2-complex related dysfunction in overgrowth syndromes: A review of EZH2, EED, and SUZ12 and their syndromic phenotypes. PMID: 31724824
Structural basis for PRC2 engagement with chromatin. PMID: 33232890
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. PMID: 16751344
Polycomb repressive 2 complex-Molecular mechanisms of function. PMID: 31095801
Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein. PMID: 22505317
suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types. PMID: 32651197
Engaging chromatin: PRC2 structure meets function. PMID: 31708574
The EZH1-SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT. PMID: 27127229
Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma. PMID: 29415665
HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression. PMID: 34167089
PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis. PMID: 25855382
SUZ12 RNA Interference Inhibits the Invasion of Gastric Carcinoma Cells. PMID: 26176059
Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation. PMID: 22843710
Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer. PMID: 25326896
miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12. PMID: 31115583
RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells. PMID: 20857416
Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer. PMID: 31234902
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. PMID: 15225548
Cryptic RNA-binding by PRC2 components EZH2 and SUZ12. PMID: 26177152
SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. PMID: 19847889
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis. PMID: 27338022
Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer. PMID: 26268246
Protease-resistant streptavidin for interaction proteomics. PMID: 32400114
Endometrial stromal sarcoma--the new genetic paradigm. PMID: 25355621
Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. PMID: 20832727
Translocations in epithelial cancers. PMID: 19406209
Cooperative DNA looping by PRC2 complexes. PMID: 34057467
Atypical NF1 Microdeletions: Challenges and Opportunities for Genotype/Phenotype Correlations in Patients with Large NF1 Deletions. PMID: 34681033
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. PMID: 17663992
Mutations and deletions of PRC2 in prostate cancer. PMID: 27000413
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. PMID: 19293275
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. PMID: 25305755
Novel MEAF6-SUZ12 fusion in ossifying fibromyxoid tumor with unusual features. PMID: 33840146
Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels. PMID: 35328741
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. PMID: 15916951
LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression. PMID: 31196742
Aberrations of EZH2 in cancer. PMID: 21367748
JAZF1-SUZ12 endometrial stromal sarcoma forming subserosal masses with extraordinary uptake of fluorodeoxyglucose on positron emission tomography: a case report. PMID: 31615558
Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis. PMID: 26036803
Low-grade endometrial stromal sarcoma with a novel MEAF6-SUZ12 fusion. PMID: 31101969
MicroRNA-105 inhibits human glioma cell malignancy by directly targeting SUZ12. PMID: 28618952
Polycomb protein Ezh1 promotes RNA polymerase II elongation. PMID: 22196887
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2. PMID: 29483650
Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment. PMID: 34544341
Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12. PMID: 25833694
Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs. PMID: 35093670
Role of PRC2-associated factors in stem cells and disease. PMID: 25271128
Polycomb repressive complex 1: Regulators of neurogenesis from embryonic to adult stage. PMID: 31608994
Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. PMID: 35676242
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. PMID: 29891558
Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis. PMID: 24169343
CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. PMID: 32807777
Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. PMID: 23879974
Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. PMID: 18753137
Long noncoding RNA mediates stroke-induced neurogenesis. PMID: 32346940
Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. PMID: 24885493
Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. PMID: 30649516
Non-canonical transcriptional regulation of INHAT subunit SET/TAF-Iβ by EZH2. PMID: 36274363
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology? PMID: 32796172
Diagnostic Pathology of Tumors of Peripheral Nerve. PMID: 33588442
SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas. PMID: 34692515
SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs. PMID: 36994588
EZH2 function in immune cell development. PMID: 32045348
Correction to: ARE/SUZ12 dual specifically-regulated adenoviral TK/GCV system for CML blast crisis cells. PMID: 35139870
The Down-Regulation of SUZ12 Accelerates the Migration and Invasion of Liver Cancer Cells via Activating ERK1/2 Pathway. PMID: 31031847
Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12. PMID: 35800781
Loss of m6A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression. PMID: 35295259
Identification of SUZ12 Haploinsufficiency due to a 1.4-Mb Deletion at 17q11.2 in a Child With Overgrowth and Intellectual Disability Syndrome. PMID: 36544348
Absence of the JAZF1/SUZ12 chimeric transcript in the immortalized non-neoplastic endometrial stromal cell line T HESCs. PMID: 22870092
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