PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke. PMID: 36163142
PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis. PMID: 32326334
miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling. PMID: 34512162
Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma. PMID: 36611861
Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia. PMID: 32467598
Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present). PMID: 27321640
Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A). PMID: 36297384
Shear stress-induced MMP1 and PDE2A expressions in coronary atherosclerosis. PMID: 33729823
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders. PMID: 33414502
Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease. PMID: 32119913
A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors. PMID: 19049345
A Homozygous Splicing Mutation in PDE2A in a Family With Atypical Rett Syndrome. PMID: 32196122
Prognostic significance of SNCA and its methylation in bladder cancer. PMID: 35346107
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus. PMID: 26178667
Salidroside Reduces PDE2A Expression by Down-regulating p53 in Human Embryonic Lung Fibroblasts. PMID: 30862347
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. PMID: 28165743
A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea. PMID: 29392776
Identification of lead BAY60-7550 analogues as potential inhibitors that utilize the hydrophobic groove in PDE2A: a molecular dynamics simulation study. PMID: 27966018
First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430. PMID: 27103022
Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells. PMID: 10375378
Et Tu PDE2? PMID: 23810892
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. PMID: 15938621
Critical role of phosphodiesterase 2A in mouse congenital heart defects. PMID: 29409032
Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes. PMID: 19632989
Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat. PMID: 31253692
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats. PMID: 30651902
A PKG inhibitor increases Ca(2+)-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition. PMID: 23449671
A Novel Inhibition Modality for Phosphodiesterase 2A. PMID: 32343157
Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[e]imidazo[2,1-c][1,2,4]triazines as Phosphodiesterase 2A Inhibitors. PMID: 31370274
Long-Timescale Simulations Revealed Critical Non-Conserved Residues of Phosphodiesterases Affecting Selectivity of BAY60-7550. PMID: 36187927
Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism. PMID: 33112806
Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness. PMID: 26915722
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome. PMID: 35813615
The Emerging Role of Phosphodiesterases in Movement Disorders. PMID: 34155691
Genetic Association of Phosphodiesterases With Human Cognitive Performance. PMID: 30800055
Phosphodiesterases Expression during Murine Cardiac Development. PMID: 33807511
Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice. PMID: 30835157
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity. PMID: 29720569
Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases. PMID: 31301407
Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease. PMID: 27787716
The role of cGMP-dependent protein kinase in controlling cardiomyocyte cGMP. PMID: 21071713
Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder. PMID: 35338117
Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. PMID: 24758774
Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. PMID: 28055196
Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages. PMID: 25063878
Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. PMID: 19506089
Sodium regulation of GAF domain function. PMID: 17956270
Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling. PMID: 36003298
Regulation of cAMP by phosphodiesterases in erythrocytes. PMID: 20631411
Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. PMID: 21571906
The distribution of phosphodiesterase 2A in the rat brain. PMID: 23000621
Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling. PMID: 18805402
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. PMID: 33087821
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. PMID: 17704206
Exome Sequencing Reveals De Novo Variants in Congenital Scoliosis. PMID: 36267860
Phosphodiesterases and compartmentalized cAMP signalling in the heart. PMID: 16466668
PDE11A negatively regulates lithium responsivity. PMID: 27646265
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights. PMID: 20004158
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. PMID: 32320669
Phosphodiesterase expression in the normal and failing heart. PMID: 30550727
[Integrating single-cell analysis and epharmalib reverse virtual screening to predict novel vascular endothelial cell targets of dapagliflozin in treating diabetic cardiomyopathy]., PMID:40528600
Activation of PDE2A moderates pathologically high cAMP/PKA responses to dopamine in dyskinetic mice., PMID:40412662
Identifying prognostic biomarkers and immune interactions in ovarian cancer associated with perfluorooctanoic acid exposure: Insights from comparative toxicogenomics and molecular docking studies., PMID:39955862
Construction and Validation of a Novel Butyrylation-Related Gene Signature Related to Prognosis, Clinical Implications, and Immune Microenvironment Characterization of Hepatocellular Carcinoma., PMID:39926543
Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure., PMID:39895533
Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum., PMID:39733958
Comprehensive analysis of PDE2A: a novel biomarker for prognostic value and immunotherapeutic potential in human cancers., PMID:39699377
Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice., PMID:39604498
Cross-pathway integration of cAMP signals through cGMP and calcium-regulated phosphodiesterases in mouse striatal cholinergic interneurons., PMID:39604216
Real-time imaging of cGMP signaling shows pronounced differences between glomerular endothelial cells and podocytes., PMID:39478086
Differential Downregulation of β1-Adrenergic Receptor Signaling in the Heart., PMID:38860414
Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation., PMID:38776406
Recurrent and novel fusions detected by targeted RNA sequencing as part of the diagnostic workflow of soft tissue and bone tumours., PMID:38738521
Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress., PMID:38395995
PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis., PMID:38325798
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling., PMID:38159569
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a., PMID:38154608
Phosphodiesterase 2 and Its Isoform A as Therapeutic Targets in the Central Nervous System Disorders., PMID:37855295
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma., PMID:37791068
Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat., PMID:37711097
Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study., PMID:37605207
Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins., PMID:37461060
A homozygous founder variant in PDE2A causes paroxysmal dyskinesia with intellectual disability., PMID:37317634
CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms., PMID:37296663
Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development., PMID:37228035
Characterization of 2 Novel Phosphodiesterase 2 Inhibitors Hcyb1 and PF-05180999 on Depression- and Anxiety-Like Behavior., PMID:37208298
Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma., PMID:36611861
Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)., PMID:36297384
PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke., PMID:36163142
A universal co-expression gene network and prognostic model for hepatic-biliary-pancreatic cancers identified by integrative analyses., PMID:36054420
Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling., PMID:36003298
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome., PMID:35813615
Prognostic Value of Stem Cell Index-Related Characteristics in Primary Hepatocellular Carcinoma., PMID:35800238
Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension., PMID:35506379
Prognostic significance of SNCA and its methylation in bladder cancer., PMID:35346107
Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder., PMID:35338117
Comparing the Performance of Different AMBER Protein Forcefields, Partial Charge Assignments, and Water Models for Absolute Binding Free Energy Calculations., PMID:35266690
Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress., PMID:35111057
Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4., PMID:34966284
Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk., PMID:34675812
miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling., PMID:34512162
Pivotal role of phosphodiesterase 10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones., PMID:34399440
Tumor immune microenvironment of primary colorectal adenocarcinomas metastasizing to the liver or lungs., PMID:34351649
Cardiac Phosphodiesterases Are Differentially Increased in Diabetic Cardiomyopathy., PMID:34339715
The Emerging Role of Phosphodiesterases in Movement Disorders., PMID:34155691
Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors., PMID:33991626
Discovery of effective phosphodiesterase 2 inhibitors with antioxidant activities for the treatment of Alzheimer's disease., PMID:33838306
Phosphodiesterases Expression during Murine Cardiac Development., PMID:33807511
Expression of Phosphodiesterase (PDE) Isoenzymes in the Human Male and Female Urethra., PMID:33777854
Shear stress-induced MMP1 and PDE2A expressions in coronary atherosclerosis., PMID:33729823
For research use only. Not for human or drug use.
