Catalog No.
YHA10601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp241-Gln387
Predicted molecular weight
18.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00408
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
cGMP-dependent 3',5'-cyclic phosphodiesterase, CGS-PDE, PDE2A, cGSPDE, Cyclic GMP-stimulated phosphodiesterase
PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke. PMID: 36163142
PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis. PMID: 32326334
miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling. PMID: 34512162
Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma. PMID: 36611861
Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia. PMID: 32467598
Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present). PMID: 27321640
Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A). PMID: 36297384
Shear stress-induced MMP1 and PDE2A expressions in coronary atherosclerosis. PMID: 33729823
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders. PMID: 33414502
Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease. PMID: 32119913
A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors. PMID: 19049345
A Homozygous Splicing Mutation in PDE2A in a Family With Atypical Rett Syndrome. PMID: 32196122
Prognostic significance of SNCA and its methylation in bladder cancer. PMID: 35346107
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus. PMID: 26178667
Salidroside Reduces PDE2A Expression by Down-regulating p53 in Human Embryonic Lung Fibroblasts. PMID: 30862347
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. PMID: 28165743
A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea. PMID: 29392776
Identification of lead BAY60-7550 analogues as potential inhibitors that utilize the hydrophobic groove in PDE2A: a molecular dynamics simulation study. PMID: 27966018
First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430. PMID: 27103022
Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells. PMID: 10375378
Et Tu PDE2? PMID: 23810892
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. PMID: 15938621
Critical role of phosphodiesterase 2A in mouse congenital heart defects. PMID: 29409032
Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes. PMID: 19632989
Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat. PMID: 31253692
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats. PMID: 30651902
A PKG inhibitor increases Ca(2+)-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition. PMID: 23449671
A Novel Inhibition Modality for Phosphodiesterase 2A. PMID: 32343157
Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[e]imidazo[2,1-c][1,2,4]triazines as Phosphodiesterase 2A Inhibitors. PMID: 31370274
Long-Timescale Simulations Revealed Critical Non-Conserved Residues of Phosphodiesterases Affecting Selectivity of BAY60-7550. PMID: 36187927
Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism. PMID: 33112806
Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness. PMID: 26915722
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome. PMID: 35813615
The Emerging Role of Phosphodiesterases in Movement Disorders. PMID: 34155691
Genetic Association of Phosphodiesterases With Human Cognitive Performance. PMID: 30800055
Phosphodiesterases Expression during Murine Cardiac Development. PMID: 33807511
Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice. PMID: 30835157
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity. PMID: 29720569
Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases. PMID: 31301407
Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease. PMID: 27787716
The role of cGMP-dependent protein kinase in controlling cardiomyocyte cGMP. PMID: 21071713
Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder. PMID: 35338117
Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. PMID: 24758774
Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. PMID: 28055196
Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages. PMID: 25063878
Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. PMID: 19506089
Sodium regulation of GAF domain function. PMID: 17956270
Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling. PMID: 36003298
Regulation of cAMP by phosphodiesterases in erythrocytes. PMID: 20631411
Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. PMID: 21571906
The distribution of phosphodiesterase 2A in the rat brain. PMID: 23000621
Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling. PMID: 18805402
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. PMID: 33087821
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. PMID: 17704206
Exome Sequencing Reveals De Novo Variants in Congenital Scoliosis. PMID: 36267860
Phosphodiesterases and compartmentalized cAMP signalling in the heart. PMID: 16466668
PDE11A negatively regulates lithium responsivity. PMID: 27646265
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights. PMID: 20004158
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. PMID: 32320669
Phosphodiesterase expression in the normal and failing heart. PMID: 30550727
For research use only. Not for human or drug use.
