Causative and common PHOX2B variants define a broad phenotypic spectrum. PMID: 31444792
Breathing with phox2b. PMID: 19651649
PHOX2B mutations and ventilatory control. PMID: 18675942
Retraction of: PHOX2B Is Associated with Neuroblastoma Cell Differentiation (doi: 10.1089/cbr.2015.1952). PMID: 35404077
Phox2B mutations and the Delta-Notch pathway in neuroblastoma. PMID: 16084642
Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis. PMID: 19712902
Guidelines for diagnosis and management of congenital central hypoventilation syndrome. PMID: 32958024
Adult-onset congenital central hypoventilation syndrome due to PHOX2B mutation. PMID: 32335870
Phox2b, congenital central hypoventilation syndrome and the control of respiration. PMID: 20691277
PHOX2B as a Reliable Marker for Neuroblastoma in Tissue and Cytology Specimens. PMID: 34965292
PHOX2B is a Sensitive and Specific Marker for the Histopathological Diagnosis of Pheochromocytoma and Paraganglioma. PMID: 36029394
Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia. PMID: 36394266
Cytoarchitecture and CO(2) sensitivity of Phox2b-positive Parafacial neurons in the newborn rat medulla. PMID: 24746043
Phox2b Immunohistochemical Staining in Detecting Enteric Neural Crest Cells in Hirschsprung Disease. PMID: 32975470
Novel PHOX2B germline mutation in childhood medulloblastoma: a case report. PMID: 33468206
Of Mice and Babies: PHOX2B and Obstructive Apneas in Congenital Central Hypoventilation Syndrome. PMID: 34634223
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations. PMID: 34048688
PHOX2B is a suppressor of neuroblastoma metastasis. PMID: 26840262
Congenital central hypoventilation syndrome: diagnosis and management. PMID: 29486608
Respiratory Control by Phox2b-expressing Neurons in a Locus Coeruleus-preBötzinger Complex Circuit. PMID: 32468398
PHOX2B Is Associated with Neuroblastoma Cell Differentiation. PMID: 26910576
Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. PMID: 15949893
Congenital central hypoventilation syndrome and the PHOX2B gene mutation. PMID: 22052119
The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma. PMID: 34752187
Congenital Central Hypoventilation Syndrome. PMID: 20301600
Pediatric disorders with autonomic dysfunction: what role for PHOX2B? PMID: 15901893
Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation. PMID: 34973291
Mutations of PHOX2B Gene in Patients of Obesity Hypoventilation Syndrome in Central India. PMID: 35982870
PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumours. PMID: 28640941
Expression of Concern re: PHOX2B Is Associated with Neuroblastoma Cell Differentiation (doi: 10.1089/cbr.2015.1952). PMID: 35544703
Congenital central hypoventilation syndrome and the PHOX2B gene: a model of respiratory and autonomic dysregulation. PMID: 20601214
Phox2B is a sensitive and reliable marker of paraganglioma-Phox2B immunohistochemistry in diagnosis of neuroendocrine neoplasms. PMID: 36656393
Chemosensitive Phox2b-expressing neurons are crucial for hypercapnic ventilatory response in the nucleus tractus solitarius. PMID: 28488367
PHOX2B Immunostaining: A Simple and Helpful Tool for the Recognition of Ganglionic Cells and Diagnosis of Hirschsprung Disease. PMID: 32604166
Common PHOX2B poly-alanine contractions impair RET gene transcription, predisposing to Hirschsprung disease. PMID: 28433712
Association between PHOX2B gene rs28647582 T>C polymorphism and Wilms tumor susceptibility. PMID: 31652452
Phox2b influences the development of a caudal dopaminergic subset. PMID: 23251691
Adult With PHOX2B Mutation and Late-Onset Congenital Central Hypoventilation Syndrome. PMID: 30518452
A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics. PMID: 23592597
PHOX2B immunolocalization of the candidate human retrotrapezoid nucleus. PMID: 19888871
Paired-like homeobox gene (PHOX2B) nonpolyalanine repeat expansion mutations (NPARMs): genotype-phenotype correlation in congenital central hypoventilation syndrome (CCHS). PMID: 33958749
Pleiotropic effect of common PHOX2B variants in Hirschsprung disease and neuroblastoma. PMID: 30799307
Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons. PMID: 20089899
Novel PHOX2B mutations in congenital central hypoventilation syndrome. PMID: 30786110
Phox2b expression in the taste centers of fish. PMID: 22473338
The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis. PMID: 30707772
Phox2b expression in the aldosterone-sensitive HSD2 neurons of the NTS. PMID: 18620340
Central respiratory chemoreception. PMID: 35965033
Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development. PMID: 26137098
Activation of Phox2b-Expressing Neurons in the Nucleus Tractus Solitarii Drives Breathing in Mice. PMID: 30626698
Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus. PMID: 28673717
A Novel c.676_677insG PHOX2B Mutation in Congenital Central Hypoventilation Syndrome. PMID: 30853048
Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. PMID: 30036539
Non-polyalanine repeat mutation in PHOX2B is detected in autopsy cases of sudden unexpected infant death. PMID: 35486589
PHOX2B germline and somatic mutations in late-onset central hypoventilation syndrome. PMID: 18079495
The paired-like homeobox 2B (PHOX2B) gene and respiratory control. PMID: 22006076
NPARM in PHOX2B: why some things just should not be expanded. PMID: 22922261
Etonogestrel Administration Reduces the Expression of PHOX2B and Its Target Genes in the Solitary Tract Nucleus. PMID: 35563209
Phox2b expressing neurons in the most rostral medulla of newborn rats. PMID: 20217327
The Phox2B homeobox gene is mutated in sporadic neuroblastomas. PMID: 15516980
Variable phenotypes in congenital central hypoventilation syndrome with PHOX2B nonpolyalanine repeat mutations. PMID: 33983112
Phox2b-expressing retrotrapezoid neurons and the integration of central and peripheral chemosensory control of breathing in conscious rats. PMID: 24363384
PHOX2B immunolabeling: a novel tool for the diagnosis of undifferentiated neuroblastomas among childhood small round blue-cell tumors. PMID: 22790854
Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. PMID: 22072691
PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism. PMID: 16144830
PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours. PMID: 29758594
Combined analysis of PHOX2B at two time points and its value for further risk stratification in high-risk neuroblastoma. PMID: 36815592
Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2. PMID: 23637167
PHOX2B analysis in non-syndromic neuroblastoma cases shows novel mutations and genotype-phenotype associations. PMID: 16691592
PHOX2B is a novel and specific marker for minimal residual disease testing in neuroblastoma. PMID: 18838715
PHOX2B mutations and genetic predisposition to neuroblastoma. PMID: 15735672
PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma. PMID: 20957039
The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity. PMID: 11060244
Genetic analysis of PHOX2B in sudden unexpected death in epilepsy cases. PMID: 25085640
PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome. PMID: 15657873
A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry. PMID: 26147470
Ultrahigh-Frequency Echocardiography of Autonomic Devoid Phox2B Homozygous Embryos Does Not Reveal a Significant Cardiac Phenotype before Embryo Death. PMID: 33293111
Germline PHOX2B mutation in hereditary neuroblastoma. PMID: 15338462
Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice., PMID:40232848
Reliability of Composite Autonomic Symptom Score (COMPASS)-31 in Congenital Central Hypoventilation Syndrome., PMID:40152101
PHOX2B -associated Congenital Central Hypoventilation Syndrome Revealed Upon Treatment With Dinutuximab-beta., PMID:39961018
Chromosomal localization of PHOX2B during M-phase is disrupted in disease-associated mutants., PMID:39933489
[Ondine syndrome: myth meets reality]., PMID:39900069
European central hypoventilation syndrome consortium description of congenital central hypoventilation syndrome neonatal onset., PMID:39883186
METTL3-induced lncARSR aggravates neuroblastoma tumorigenic properties through stabilizing PHOX2B., PMID:39461245
Comparison of human pluripotent stem cell differentiation protocols to generate neuroblastoma tumors., PMID:39367051
Identification of a histone deacetylase inhibitor as a therapeutic candidate for congenital central hypoventilation syndrome., PMID:39329148
A new nonsense pathogenic variant in exon 1 of PHOX2B leads to the diagnosis of congenital central hypoventilation syndrome with intra-familial variability., PMID:39261201
Nucleus of the solitary tract neuronal degeneration and impaired hypoxia response in a model of Parkinson's disease., PMID:39147260
[Congenital Central Hypoventilation Syndrome: neonatal diagnosis and management]., PMID:39093216
Genetic identification of medullary neurons underlying congenital hypoventilation., PMID:38896627
Long non-coding RNA MALAT 1 and PHOX2B expression in olfactory neuroblastomas and sympathetic neuroblastomas., PMID:38878689
Structural characterization of PHOX2B and its DNA interaction shed light on the molecular basis of the +7Ala variant pathogenicity in CCHS., PMID:38873078
Neuroblastoma Predisposition and Surveillance-An Update from the 2023 AACR Childhood Cancer Predisposition Workshop., PMID:38860978
Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice., PMID:38836780
Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice., PMID:38830761
Congenital central hypoventilation syndrome in korea: 20 years of clinical observation and evaluation of the ventilation strategy in a single center., PMID:38780650
Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats., PMID:38727716
PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas., PMID:38458747
An unusual ophthalmologic finding in a patient with congenital central hypoventilation syndrome., PMID:38403966
Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome., PMID:38403573
Computer-aided diagnostic screen for Congenital Central Hypoventilation Syndrome with facial phenotype., PMID:38238566
[Study of GCN repeats of PHOX2B gene among individuals from southwest China and diagnosis of two patients with Congenital central hypoventilation syndrome]., PMID:38171556
Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models., PMID:38052789
Targeting of intracellular oncoproteins with peptide-centric CARs., PMID:37938771
The Molecular Circadian Clock of Phox2b-expressing Cells Drives Daily Variation of the Hypoxic but Not Hypercapnic Ventilatory Response in Mice., PMID:37342417
Obstructive sleep apnea as a presentation of congenital central hypoventilation syndrome., PMID:37185129
Combined analysis of PHOX2B at two time points and its value for further risk stratification in high-risk neuroblastoma., PMID:36815592
Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia., PMID:36394266
Spectrum of paired-like homeobox 2b immunoexpression in pediatric brain tumors with embryonal morphology., PMID:35763016
Neurocognitive monitoring in congenital central hypoventilation syndrome with the NIH Toolbox®., PMID:35574731
Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation., PMID:34973291
PHOX2B as a Reliable Marker for Neuroblastoma in Tissue and Cytology Specimens., PMID:34965292
The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma., PMID:34752187
Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs., PMID:34732890
A medullary centre for lapping in mice., PMID:34728601
Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression., PMID:34645823
Genetic study of a patient with congenital central hypoventilation syndrome in Iran: a case report., PMID:34626313
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations., PMID:34048688
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism., PMID:34043943
Variable phenotypes in congenital central hypoventilation syndrome with PHOX2B nonpolyalanine repeat mutations., PMID:33983112
NH2-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo., PMID:33881351
Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in Phox2b-derived astrocytes ablated mice., PMID:33502943
Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice., PMID:33475140
Ultrahigh-Frequency Echocardiography of Autonomic Devoid Phox2B Homozygous Embryos Does Not Reveal a Significant Cardiac Phenotype before Embryo Death., PMID:33293111
A respiratory/Hirschsprung phenotype in a three-generation family associated with a novel pathogenic PHOX2B splice donor mutation., PMID:33047879
Phox2b Immunohistochemical Staining in Detecting Enteric Neural Crest Cells in Hirschsprung Disease., PMID:32975470
Differential Contribution of the Retrotrapezoid Nucleus and C1 Neurons to Active Expiration and Arousal in Rats., PMID:32973046
For research use only. Not for human or drug use.
