Catalog No.
YHK88201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg123-Arg315
Predicted molecular weight
25.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H307
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PNN, MEMA, SR-like protein, Nuclear protein SDK3, Domain-rich serine protein, DRSP, 140 kDa nuclear and cell adhesion-related phosphoprotein, Pinin, Desmosome-associated protein, Melanoma metastasis clone A protein, DRS protein, DRS
Pinin Induces Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating m6A Modification. PMID: 34917148
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. PMID: 34879239
Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis. PMID: 27175589
LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. PMID: 32364663
Methyltransferase like 3 enhances pinin mRNA stability through N6 -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma. PMID: 35996844
Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells. PMID: 26871283
Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion. PMID: 33811436
Pinin promotes tumor progression via activating CREB through PI3K/AKT and ERK/MAPK pathway in prostate cancer. PMID: 33948358
Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. PMID: 8922384
Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway. PMID: 27107420
Role of cell adhesion-associated protein, pinin (DRS/memA), in corneal epithelial migration. PMID: 10798648
Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. PMID: 10645008
Cloning and analysis of cDNA encoding murine pinin. PMID: 9332356
Correction: Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells. PMID: 28403579
Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions. PMID: 31167655
Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis. PMID: 20637749
Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. PMID: 14578391
Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. PMID: 10486276
Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. PMID: 10809736
SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin. PMID: 31313837
The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. PMID: 22388736
Dissection of the role of Pinin in the development of zebrafish posterior pharyngeal cartilages. PMID: 22527695
Transgenic mice expressing mutant Pinin exhibit muscular dystrophy, nebulin deficiency and elevated expression of slow-type muscle fiber genes. PMID: 24309110
Spatial and temporal expression profile of pinin during mouse development. PMID: 16427813
Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. PMID: 9447706
Modulation of alternative pre-mRNA splicing in vivo by pinin. PMID: 12051732
Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. PMID: 17654715
Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing. PMID: 16823614
Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. PMID: 15358154
1.06-μm InGaAs/GaAs multiple-quantum-well optical thyristor lasers with a PiNiN structure. PMID: 24322153
Radio Frequency IDentification for Meat Supply-Chain Digitalisation. PMID: 32883048
The role and regulation of Pnn in proliferative and non-dividing cells: Form embryogenesis to pathogenesis. PMID: 34237338
Prognostic value of PNN in prostate cancer and its correlation with therapeutic significance. PMID: 36468018
Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation. PMID: 36626563
Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. PMID: 14729963
A potential peptide pathway from viruses to oral lichen planus. PMID: 25776836
Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice. PMID: 35326115
Chemically robust and readily available quinoline-based PNN iron complexes: application in C-H borylation of arenes. PMID: 34812447
DE-PNN: Differential Evolution-Based Feature Optimization with Probabilistic Neural Network for Imbalanced Arrhythmia Classification. PMID: 35746232
The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma. PMID: 35257416
PNN and KCNQ1OT1 Can Predict the Efficacy of Adjuvant Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer Patients. PMID: 33208224
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain. PMID: 32745992
Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation. PMID: 31772567
DNN-PNN: A parallel deep neural network model to improve anticancer drug sensitivity. PMID: 36410694
The Milstein Bipyridyl PNN Pincer Complex of Ruthenium Becomes a Noyori-Type Catalyst under Reducing Conditions. PMID: 33166129
Miniature Transducer Using PNN-PZT-based Ceramic for Intravascular Ultrasound. PMID: 30908214
Integration of Milstein Ru-PNN and Rh-Tribi/Tetrabi for Isomerization Linear Selective Hydroformylation of Far Internal Alkenes. PMID: 36473047
Research on SPDTRS-PNN based intelligent assistant diagnosis for breast cancer. PMID: 36928059
Pnn and SR family proteins are differentially expressed in mouse central nervous system. PMID: 21437620
Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. PMID: 33027948
Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain. PMID: 34233180
Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. PMID: 14517304
Venlafaxine stimulates PNN proteolysis and MMP-9-dependent enhancement of gamma power; relevance to antidepressant efficacy. PMID: 30697747
RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells. PMID: 26900324
Role of Pnn in alternative splicing of a specific subset of lncRNAs of the corneal epithelium. PMID: 25489234
Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells. PMID: 15735603
Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells. PMID: 23299472
Dehydroalkylative Activation of CNN- and PNN-Pincer Ruthenium Catalysts for Ester Hydrogenation. PMID: 31589441
Ruthenium PNN(O) Complexes: Cooperative Reactivity and Application as Catalysts for Acceptorless Dehydrogenative Coupling Reactions. PMID: 29353952
PNN-curve: a new 2D graphical representation of DNA sequences and its application. PMID: 16945387
Daily Record of Severity of Problems (DRSP): reliability and validity. PMID: 16172836
Estetrol: A New Choice for Contraception. PMID: 34884326
Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone. PMID: 33428907
Drospirenone 4 mg-only pill (DOP) in 24+4 regimen: a new option for oral contraception. PMID: 32538188
The drospirenone (DRSP)-only pill: clinical implications in the daily use. PMID: 36724207
[Extracontraceptive benefits of EE/DRSP (Yaz) in 24+4 day regimen]. PMID: 20595950
Evaluation of the effect of a new oral contraceptive containing estetrol and drospirenone on hemostasis parameters. PMID: 32956694
Estetrol-drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results. PMID: 34000251
Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause. PMID: 35306927
Acupuncture and acupressure for premenstrual syndrome. PMID: 30105749
Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone-only pill. PMID: 31321765
The reliability and validity of the Japanese version of the Daily Record of Severity of Problems (J-DRSP) and Development of a Short-Form version (J-DRSP (SF)) to assess symptoms of premenstrual syndrome among Japanese women. PMID: 33736660
Estetrol-Drospirenone combination oral contraceptive: a clinical study of contraceptive efficacy, bleeding pattern and safety in Europe and Russia. PMID: 34245666
Use of drospirenone/ethinyl estradiol (DRSP/EE) among women with acne reduces acne treatment-related resources. PMID: 21892859
Correction to: The reliability and validity of the Japanese version of the daily record of severity of problems (J-DRSP) and development of a short-form version (J-DRSP (SF)) to assess symptoms of premenstrual syndrome among Japanese women. PMID: 34972535
For research use only. Not for human or drug use.
