Catalog No.
PHA18501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CES2 (His452-Leu559).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Cocaine esterase, CES2, Carboxylesterase 2, CE-2, ICE, Methylumbelliferyl-acetate deacetylase 2, hCE-2
Purification
Purified by antigen affinity column.
Accession
O00748
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2., PMID:34536357
IL-6 downregulates hepatic carboxylesterases via NF-κB activation in dextran sulfate sodium-induced colitis., PMID:34217990
Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys., PMID:31836607
Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans., PMID:28966098
Single-nucleotide polymorphisms in the genes of CES2, CDA and enzymatic activity of CDA for prediction of the efficacy of capecitabine-containing chemotherapy in patients with metastatic breast cancer., PMID:28827188
Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase., PMID:26558823
A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production., PMID:26408002
Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1., PMID:23946449
Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation., PMID:23530020
Catabolism of 4-hydroxy-2-trans-nonenal by THP1 monocytes/macrophages and inactivation of carboxylesterases by this lipid electrophile., PMID:21878322
Carboxylesterase 2 is downregulated in colorectal cancer following progression of the disease., PMID:18259949
Tumor targeting carboxylesterase fused with anti-CEA scFv improve the anticancer effect with a less toxic dose of irinotecan., PMID:18157147
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats., PMID:14680511
Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family., PMID:12859986
For research use only. Not for human or drug use.
