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Anti-FBN1/Fibrillin-1 Polyclonal Antibody

Catalog #:   PHE12501 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P35555
Overview

Catalog No.

PHE12501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FBN1/Fibrillin-1 (Ser2732-His2871).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

FBN,Fibrillin-1,FBN1

Purification

Purified by antigen affinity column.

Accession

P35555

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with FBN1/Fibrillin-1 antibody (PHE12501) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 16 kDa
    Observed MW: 16 kDa
References

Stabilisation of extracellular matrix is crucial to rapamycin-mediated life span increase in Marfan mgR/mgR mice., PMID:40021021

Inhibition of aortic CX3CR1+ macrophages mitigates thoracic aortic aneurysm progression in Marfan syndrome in mice., PMID:39817456

Development of a mix-and-read assay for human asprosin using antibody-oligonucleotide probes and thermofluorimetric analysis., PMID:39171961

Asprosin aggravates atherosclerosis via regulating the phenotype transformation of vascular smooth muscle cells., PMID:38677690

Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis., PMID:38347040

IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome., PMID:36924234

Circulating fibrillin fragment concentrations in patients with and without aortic pathology., PMID:36568280

Overexpression and ELISA-based detection of asprosin in cultured cells and mice., PMID:36240062

Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression., PMID:35901491

Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome., PMID:35135328

The effects of adalimumab on the rat autotransplantation endometriosis model: A placebo-controlled randomized study., PMID:35040600

Compositional Analysis of Extracellular Aggregates in the Eyes of Patients With Exfoliation Syndrome and Exfoliation Glaucoma., PMID:34964803

Prenatal diagnosis of primary congenital glaucoma and histopathological features in a fetal globe with cytochrome p4501B1 mutations., PMID:34730456

Histopathological Examination of the Mucosal Effects of Obstetric Gel on Vaginal Wound Healing in an Incision-Inflicted Rat Model., PMID:34712531

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10., PMID:34424262

Asprosin-neutralizing antibodies as a treatment for metabolic syndrome., PMID:33904407

Marfan syndrome resulting from a rare pathogenic FBN1 variant, ascertained through a proband with IgG4-related arteriopathy., PMID:33878224

Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature., PMID:33673009

Expression of Lymphatic Markers in the Berger's Space and Bursa Premacularis., PMID:33669860

Three-Dimensional Imaging of Intraplaque Neovascularization in a Mouse Model of Advanced Atherosclerosis., PMID:32610324

Pathogenic roles of autoantibodies in systemic sclerosis: Current understandings in pathogenesis., PMID:35382028

Energy Regulation Mechanism and Therapeutic Potential of Asprosin., PMID:32198197

Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation., PMID:31402541

Preliminary analysis of the association of TRPV1 to the formation of Marfan syndrome aneurysms., PMID:31073986

Localization, fate and interactions of Emilin-1 in human skin., PMID:30843221

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage., PMID:30201140

Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery., PMID:29559302

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection., PMID:29515038

Asprosin is a centrally acting orexigenic hormone., PMID:29106398

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice., PMID:28768908

Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ., PMID:27487789

Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis., PMID:27156795

Asprosin, a Fasting-Induced Glucogenic Protein Hormone., PMID:27087445

The p.Gly61Glu Mutation in CYP1B1 Affects the Extracellular Matrix in Glaucoma Patients., PMID:26982174

Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar., PMID:26644005

Fibrillin-1 microfibrils influence adult bone marrow hematopoiesis., PMID:26610678

Regeneration of elastic fibers by three-dimensional culture on a collagen scaffold and the addition of latent TGF-β binding protein 4 to improve elastic matrix deposition., PMID:26342558

Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGFβ Activity Within the Marrow Niche., PMID:26189658

Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors., PMID:25807551

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia., PMID:25762570

Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells Through TGFβ1-Mediated Upregulation of Periostin Expression., PMID:25655430

Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome., PMID:25614286

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development., PMID:25524144

Human eye development is characterized by coordinated expression of fibrillin isoforms., PMID:25406291

Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome., PMID:25359856

Elastin development-associated extracellular matrix constituents of subepithelial connective tissue in human pterygium., PMID:25183766

Spatiotemporal mapping of matrix remodelling and evidence of in situ elastogenesis in experimental abdominal aortic aneurysms., PMID:24799390

Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study., PMID:24353434

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome., PMID:24265020

Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells., PMID:24204045

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-FBN1/Fibrillin-1 Polyclonal Antibody [PHE12501]
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