Anti-SLC12A3 Polyclonal Antibody

Catalog No.

PHF07701

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SLC12A3 (Glu3-Cys146).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

TSC, SLC12A3, NCC, Solute carrier family 12 member 3, Na-Cl cotransporter, Thiazide-sensitive sodium-chloride cotransporter, Na-Cl symporter

Purification

Purified by antigen affinity column.

Accession

P55017

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Several first-line anti-hypertensives act on fibrosarcoma progression and PD1ab blockade therapy., PMID:38373964

HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule., PMID:36129874

A case of Gitelman syndrome with membranous nephropathy., PMID:35883046

Identification of Hub Biomarkers and Immune-Related Pathways Participating in the Progression of Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis., PMID:35069594

Genetic Analysis of Gitelman Syndrome: Co-existence with Hyperthyroidism in a Two-year-old Boy., PMID:33121425

Molecular Patterns Discriminate Accommodation and Subclinical Antibody-mediated Rejection in Kidney Transplantation., PMID:30801516

A NOVEL COMPOUND HETEROZYGOUS VARIANT OF SLC12A3 GENE IN A PEDIGREE WITH GITELMAN SYNDROME CO-EXISTENT WITH THYROID DYSFUNCTION., PMID:30084681

Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation., PMID:27803420

Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling., PMID:26561651

SPAK-mediated NCC regulation in response to low-K+ diet., PMID:25651563

Urinary exosomes in the diagnosis of Gitelman and Bartter syndromes., PMID:25422309

Immunolocalization of WNK4 in mouse kidney., PMID:21660484

Differential expression of Na+-Cl- cotransporter and Na+-K+-Cl- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes., PMID:21084680

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension., PMID:20921400

Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome., PMID:20848653

Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule., PMID:20445498

Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation., PMID:20007345

Acquired gitelman syndrome., PMID:21468178

Reduced urinary excretion of thiazide-sensitive Na-Cl cotransporter in Gitelman syndrome: preliminary data., PMID:17954289

Gitelman syndrome and glomerulonephritis., PMID:17043881

Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney., PMID:12388412

Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter., PMID:11832422

Regulation of the sodium transporters NHE3, NKCC2 and NCC in the kidney., PMID:11496061

Detection of Na(+) transporter proteins in urine., PMID:11053490

Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome., PMID:10516289

11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules., PMID:9697656

Thiazide treatment of rats provokes apoptosis in distal tubule cells., PMID:8887276

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