Catalog No.
PHK06101
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PROK2 (Ile30-Gln128).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PK2, Prokineticin-2, PROK2, BV8, Protein Bv8 homolog
Purification
Purified by antigen affinity column.
Accession
Q9HC23
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Prokineticin 2 protein is diurnally expressed in PER2-containing clock neurons in the mouse suprachiasmatic nucleus., PMID:39755259
G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils., PMID:34643696
Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer., PMID:32817421
Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung., PMID:29643149
The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis., PMID:29537336
Method development to quantify Bv8 expression in circulating CD11b+ cells in patients with neovascular age-related macular degeneration (nvAMD) exhibiting Anti-VEGF refractoriness., PMID:27256991
Involvement of Spinal Bv8/Prokineticin 2 in a Rat Model of Cancer-Induced Bone Pain., PMID:25641661
Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy., PMID:24957319
Dual VEGF/VEGFR inhibition in advanced solid malignancies: clinical effects and pharmacodynamic biomarkers., PMID:24842548
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy., PMID:23913124
A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer., PMID:23372791
Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1., PMID:22406619
Upregulation of endocrine gland-derived vascular endothelial growth factor in papillary thyroid cancers displaying infiltrative patterns, lymph node metastases, and BRAF mutation., PMID:21385081
Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake., PMID:19933997
Prokineticin-1 evokes secretory and contractile activity in rat small intestine., PMID:19930539
Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis., PMID:19405944
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models., PMID:19346489
Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells., PMID:18632597
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression., PMID:18268320
Bv8 regulates myeloid-cell-dependent tumour angiogenesis., PMID:18064003
Induction of a virus-specific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants., PMID:11270596
For research use only. Not for human or drug use.
