Anti-THBS2 Polyclonal Antibody

Catalog No.

PHE10901

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human THBS2 (Asp968-Ile1172).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Thrombospondin-2, TSP2, THBS2

Purification

Purified by antigen affinity column.

Accession

P35442

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Elucidating the Predominant Role of AEBP1 in Different Types of Cancers with a Focus on Glioblastoma Progression - A Review., PMID:40375702

Rapid and Sensitive Detection of Thrombospondin-2 Using Nanoparticle Sensors for Cancer Screening and Prognosis., PMID:40141965

Identification of the M2 Macrophage-associated Gene THBS2 as a Predictive Marker for Inflammatory Cancer Transformation., PMID:39045635

Preparation of polyclonal antibody against thrombospondin 2 recombinant protein and its functional verification in pulmonary hypertension syndrome in broilers., PMID:38906344

Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer., PMID:38302471

Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer., PMID:38194163

TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies., PMID:37718518

Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length., PMID:35130326

Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway., PMID:34803392

Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma., PMID:34329660

Elevated Levels of Endoglin, Endostatin, FGF-α, HGF, and Thrombospondin-2 in Aqueous Humor of nAMD Patients., PMID:33793358

Context-dependent monoclonal antibodies against protein carbamidomethyl-cysteine., PMID:33232360

Thrombospondin-2 is upregulated in patients with aortic dissection and enhances angiotensin II-induced smooth muscle cell apoptosis., PMID:33093888

Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF-κB activation., PMID:33021341

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers., PMID:32795414

Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer., PMID:32444947

An Efficient Schistosoma japonicum Bivalent Membrane Protein Antigen DNA Vaccine Against Schistosomiasis in Mice., PMID:31811711

Expression of vascular infarction-related molecules after anti-vascular endothelium growth factor treatment for diabetic macular edema., PMID:31451777

Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis., PMID:31075265

Therapeutic Role for TSP-2 Antibody in a Murine Asthma Model., PMID:29393209

Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases., PMID:28669815

New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study., PMID:28039493

Monoclonal antibodies to murine thrombospondin-1 and thrombospondin-2 reveal differential expression patterns in cancer and low antigen expression in normal tissues., PMID:24925479

Comparison of protein immunoprecipitation-multiple reaction monitoring with ELISA for assay of biomarker candidates in plasma., PMID:24224610

Thrombospondin-2 secreted by human umbilical cord blood-derived mesenchymal stem cells promotes chondrogenic differentiation., PMID:23843355

Distribution of thrombospondins and their neuronal receptor α2δ1 in the rat retina., PMID:23541831

[TSP-2 suppresses the expression and DNA-binding activity of nuclear factor-κB p65 protein in mice with ulcerative colitis]., PMID:23529246

The wound healing effects of vitamin A eye drops after a corneal alkali burn in rats., PMID:23106861

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis., PMID:22730375

Comparison of FRPE and human embryonic stem cell-derived RPE behavior on aged human Bruch's membrane., PMID:21460262

Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis., PMID:21454305

[Effect of TSP-2 antibody against a single epitope of mouse Toll-like receptor 2 extracellular domain on nuclear factor-kappa B and cytokine expression in the intestine of septic mice]., PMID:21354910

Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer., PMID:21224365

CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo., PMID:20714802

Thrombospondin 1--a key astrocyte-derived neurogenic factor., PMID:20124433

Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers., PMID:19432887

Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization., PMID:19421039

Microvessel density and CpG island methylation of the THBS2 gene in malignant ovarian tumors., PMID:18955754

Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain., PMID:18682400

Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability., PMID:18499674

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells., PMID:18032585

Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations., PMID:17620335

Increased cortical expression of two synaptogenic thrombospondins in human brain evolution., PMID:17182969

Platelets, thrombospondin-1 and human dermal fibroblasts cooperate for stimulation of endothelial cell tubulogenesis through VEGF and PAI-1 regulation., PMID:17126831

ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2., PMID:17082774

Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells., PMID:17046999

Differential zonal expression and adrenocorticotropin regulation of secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, in the midgestation human fetal adrenal gland: implications for adrenal development., PMID:16735494

Function-blocking antithrombospondin-1 monoclonal antibodies., PMID:16420580

Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer., PMID:16365183

When does the presence of the target predict response to the targeted agent?, PMID:16365177

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