Catalog No.
PHA14001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human BIN1 (Met1-Ser276).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
AMPHL, Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1
Purification
Purified by antigen affinity column.
Accession
O00499
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Gut-brain connections in neurodegenerative disease: immunotherapeutic targeting of Bin1 in inflammatory bowel disease and Alzheimer's disease., PMID:37521457
Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis., PMID:37479833
The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer's Disease Mouse Model., PMID:37298634
Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment., PMID:36322599
Ventricular opening and cerebrospinal fluid circulation accelerate the biodegradation process of carmustine wafers suggesting their immunomodulation potential in the human brain., PMID:35802230
The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner., PMID:35241726
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems., PMID:34708251
BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology., PMID:32727516
Cellular Assays for Measuring Dynamin Activity in Muscle Cells., PMID:32529371
Bin1 antibody lowers the expression of phosphorylated Tau in Alzheimer's disease., PMID:31211444
Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis., PMID:30269357
Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types., PMID:30075156
Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts., PMID:27488240
Spatiotemporal Expression Patterns and Antibody Reactivity of Taeniidae Endophilin B1., PMID:27487955
Bin1 Antibodies for IBD Therapy: Is Permeability the Answer BAR None?, PMID:26694171
Novel Colitis Immunotherapy Targets Bin1 and Improves Colon Cell Barrier Function., PMID:26195312
BIN1 tumor suppressor regulates Fas/Fas ligand-mediated apoptosis through c-FLIP in cutaneous T-cell lymphoma., PMID:25578476
Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N., PMID:25238490
Novel autoimmune response in a tauopathy mouse model., PMID:24454278
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR., PMID:22976291
Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System., PMID:22254144
Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy., PMID:22096584
Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells., PMID:15212950
Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: diverse sites of nuclear expression and losses in prostate cancer., PMID:12532338
Cloning and expression of the putative aggregation factor from the marine sponge Geodia cydonium., PMID:11590245
Pattern of expression of c-Myc, Max and Bin1 in human anagen hair follicles., PMID:11422041
The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells., PMID:9242458
For research use only. Not for human or drug use.
